YOR120W / GCY1

Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR120W / GCY1

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:5.30|P-value:2.06E-6 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.67|P-value:6.33E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.66|P-value:7.63E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.87|P-value:3.91E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:4.08|P-value:1.97E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.64|P-value:8.01E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:4.19|P-value:1.36E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.31|P-value:9.14E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.73|P-value:6.06E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.63|P-value:8.14E-4 ID:SGTC_1826|Compound:st055655|FD-Score:4.13|P-value:1.70E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.72|P-value:6.25E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.87|P-value:3.92E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:8.07|P-value:1.12E-12 ID:SGTC_2136|Compound:5328288|FD-Score:4.98|P-value:7.59E-6 ID:SGTC_2218|Compound:6965428|FD-Score:-4.32|P-value:7.50E-5 ID:SGTC_2312|Compound:7706453|FD-Score:5.01|P-value:6.70E-6 ID:SGTC_2380|Compound:9035439|FD-Score:4.52|P-value:4.29E-5 ID:SGTC_2401|Compound:5128683|FD-Score:4.23|P-value:1.23E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.19|P-value:1.39E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:4.79|P-value:1.61E-5 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.92|P-value:2.87E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.90|P-value:3.60E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.59|P-value:9.38E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:6.87|P-value:1.13E-9 ID:SGTC_2755|Compound:lomerizine|FD-Score:7.71|P-value:1.00E-11 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.77|P-value:1.73E-5 ID:SGTC_2932|Compound:9016711|FD-Score:-3.97|P-value:2.50E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.69|P-value:6.79E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.68|P-value:7.15E-4 ID:SGTC_3301|Compound:9125354|FD-Score:3.59|P-value:9.19E-4 ID:SGTC_3319|Compound:9138450|FD-Score:4.58|P-value:3.46E-5 ID:SGTC_3324|Compound:9138759|FD-Score:3.75|P-value:5.75E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:5.30|P-value:2.06E-6 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.67|P-value:6.33E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.66|P-value:7.63E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.87|P-value:3.91E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:4.08|P-value:1.97E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.64|P-value:8.01E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:4.19|P-value:1.36E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.31|P-value:9.14E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.73|P-value:6.06E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.63|P-value:8.14E-4 ID:SGTC_1826|Compound:st055655|FD-Score:4.13|P-value:1.70E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.72|P-value:6.25E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.87|P-value:3.92E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:8.07|P-value:1.12E-12 ID:SGTC_2136|Compound:5328288|FD-Score:4.98|P-value:7.59E-6 ID:SGTC_2218|Compound:6965428|FD-Score:-4.32|P-value:7.50E-5 ID:SGTC_2312|Compound:7706453|FD-Score:5.01|P-value:6.70E-6 ID:SGTC_2380|Compound:9035439|FD-Score:4.52|P-value:4.29E-5 ID:SGTC_2401|Compound:5128683|FD-Score:4.23|P-value:1.23E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.19|P-value:1.39E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:4.79|P-value:1.61E-5 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.92|P-value:2.87E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.90|P-value:3.60E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.59|P-value:9.38E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:6.87|P-value:1.13E-9 ID:SGTC_2755|Compound:lomerizine|FD-Score:7.71|P-value:1.00E-11 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.77|P-value:1.73E-5 ID:SGTC_2932|Compound:9016711|FD-Score:-3.97|P-value:2.50E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.69|P-value:6.79E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.68|P-value:7.15E-4 ID:SGTC_3301|Compound:9125354|FD-Score:3.59|P-value:9.19E-4 ID:SGTC_3319|Compound:9138450|FD-Score:4.58|P-value:3.46E-5 ID:SGTC_3324|Compound:9138759|FD-Score:3.75|P-value:5.75E-4

Top fitness defect scores for YOR120W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2129 girgensonine 8.07 121.0 µM 1.12E-12 heme biosynthesis & mitochondrial translocase 5 3.61E-16
2 SGTC_2755 lomerizine 7.71 42.7 µM 1.00E-11 2 6.42E-15
3 SGTC_2754 granisetron 6.87 64.0 µM 1.13E-9 3 3.13E-12
4 SGTC_20 0481-0013 5.30 4.9 µM 2.06E-6 9 5.78E-8
5 SGTC_2312 7706453 5.01 155.7 µM 6.70E-6 13 2.69E-7
6 SGTC_2136 5328288 4.98 199.3 µM 7.59E-6 8 3.17E-7
7 SGTC_2657 nystatin 4.79 74.4 µM 1.61E-5 5 8.46E-7
8 SGTC_2757 clomiphene 4.77 4.2 µM 1.73E-5 fatty acid desaturase (OLE1) 23 9.28E-7
9 SGTC_3319 9138450 4.58 16.8 µM 3.46E-5 7 2.29E-6
10 SGTC_2380 9035439 4.52 200.0 µM 4.29E-5 endomembrane recycling 10 3.04E-6
11 SGTC_1402 3909-7673 4.31 35.9 µM 9.14E-5 15 8.13E-6
12 SGTC_2401 5128683 4.23 200.0 µM 1.23E-4 31 1.19E-5
13 SGTC_982 1491-0518 4.19 27.5 µM 1.36E-4 11 1.36E-5
14 SGTC_2520 obtusaquinone 4.19 4.7 µM 1.39E-4 14 1.40E-5
15 SGTC_1826 st055655 4.13 41.6 µM 1.70E-4 ERG2 37 1.82E-5
16 SGTC_878 0828-0289 4.08 13.7 µM 1.97E-4 43 2.21E-5
17 SGTC_2730 imipramine 3.90 71.3 µM 3.60E-4 27 4.84E-5
18 SGTC_560 2332-1943 3.87 155.0 µM 3.91E-4 13 5.38E-5
19 SGTC_1939 st074455 3.87 53.6 µM 3.92E-4 30 5.41E-5
20 SGTC_3324 9138759 3.75 60.8 µM 5.75E-4 24 8.90E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 3.04E-19 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.124 6.39E-13 YHR085W IPI1 het Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; IPI1 is an essential gene
0.108 3.14E-10 YIL117C PRM5 hom Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling
0.098 1.15E-8 YAL048C GEM1 hom Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases
0.091 1.42E-7 YML114C TAF8 het TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.088 3.99E-7 YDR078C SHU2 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.086 7.03E-7 YOL115W PAP2 hom Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p
0.083 1.37E-6 YDL236W PHO13 hom Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity
0.083 1.61E-6 YMR225C MRPL44 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.082 1.75E-6 YKR040C_d YKR040C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
0.080 3.94E-6 YMR258C ROY1 hom GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p
0.078 6.26E-6 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.076 9.53E-6 YPL098C MGR2 hom Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype)
0.076 9.94E-6 YNL097C PHO23 hom Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3
0.075 1.40E-5 YDR153C ENT5 hom Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin