YOR125C / CAT5

Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR125C / CAT5

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:18.20|P-value:3.24E-82 ID:SGTC_46|Compound:0329-0187a|FD-Score:5.55|P-value:2.26E-9 ID:SGTC_59|Compound:0330-0160|FD-Score:3.34|P-value:2.16E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:20.30|P-value:2.91E-102 ID:SGTC_67|Compound:0335-0847|FD-Score:15.30|P-value:7.10E-59 ID:SGTC_70|Compound:0141-0289|FD-Score:3.06|P-value:6.25E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:17.30|P-value:4.93E-75 ID:SGTC_87|Compound:0100-0052|FD-Score:4.55|P-value:7.73E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:4.79|P-value:2.11E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:4.20|P-value:4.68E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:10.40|P-value:2.76E-28 ID:SGTC_158|Compound:k038-0087|FD-Score:11.40|P-value:1.28E-33 ID:SGTC_163|Compound:1327-0036|FD-Score:3.51|P-value:1.06E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:6.26|P-value:2.00E-11 ID:SGTC_168|Compound:3970-0862|FD-Score:5.44|P-value:4.57E-9 ID:SGTC_195|Compound:4234-0266|FD-Score:3.38|P-value:1.77E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:5.85|P-value:3.20E-10 ID:SGTC_216|Compound:k038-0035|FD-Score:5.69|P-value:9.75E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:37.60|P-value:0 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.57|P-value:6.91E-7 ID:SGTC_294|Compound:k038-0071|FD-Score:4.85|P-value:1.56E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:3.32|P-value:2.31E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:6.04|P-value:8.80E-11 ID:SGTC_367|Compound:0335-0881|FD-Score:3.50|P-value:1.11E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:8.48|P-value:1.74E-19 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.32|P-value:2.29E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.21|P-value:3.58E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.58|P-value:6.52E-7 ID:SGTC_717|Compound:1532-0246|FD-Score:2.94|P-value:9.72E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:6.26|P-value:1.94E-11 ID:SGTC_824|Compound:1304-0008|FD-Score:4.33|P-value:2.46E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:3.01|P-value:7.37E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:5.20|P-value:2.02E-8 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.01|P-value:7.45E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:-3.96|P-value:1.45E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:-5.11|P-value:3.35E-8 ID:SGTC_1206|Compound:3978-0017|FD-Score:11.80|P-value:7.19E-36 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.05|P-value:6.41E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:5.64|P-value:1.27E-9 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.69|P-value:4.99E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:-2.95|P-value:8.91E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.85|P-value:2.44E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.51|P-value:1.03E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.68|P-value:5.05E-5 ID:SGTC_1627|Compound:st003713|FD-Score:4.29|P-value:2.95E-6 ID:SGTC_1635|Compound:st007035|FD-Score:21.50|P-value:9.95E-115 ID:SGTC_1638|Compound:st008370|FD-Score:3.17|P-value:4.18E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.53|P-value:9.59E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-4.98|P-value:6.94E-8 ID:SGTC_1801|Compound:st050089|FD-Score:-3.21|P-value:3.39E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-5.45|P-value:4.21E-9 ID:SGTC_1820|Compound:st053765|FD-Score:3.50|P-value:1.09E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-3.31|P-value:2.28E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-4.34|P-value:2.25E-6 ID:SGTC_2041|Compound:5107442|FD-Score:4.09|P-value:7.83E-6 ID:SGTC_2056|Compound:5235370|FD-Score:3.37|P-value:1.86E-4 ID:SGTC_2124|Compound:5246320|FD-Score:-3.30|P-value:2.39E-4 ID:SGTC_2358|Compound:9037157|FD-Score:2.99|P-value:7.92E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.24|P-value:3.13E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.33|P-value:2.15E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.97|P-value:8.29E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.55|P-value:2.22E-9 ID:SGTC_2585|Compound:alliin|FD-Score:3.16|P-value:4.25E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:2.96|P-value:8.82E-4 ID:SGTC_2796|Compound:7949634|FD-Score:5.69|P-value:9.23E-10 ID:SGTC_2799|Compound:7812892|FD-Score:-3.89|P-value:1.91E-5 ID:SGTC_2801|Compound:7907800|FD-Score:4.29|P-value:2.90E-6 ID:SGTC_2802|Compound:7925815|FD-Score:4.00|P-value:1.19E-5 ID:SGTC_2803|Compound:7707263|FD-Score:-3.55|P-value:8.76E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.40|P-value:1.61E-6 ID:SGTC_3118|Compound:9124250|FD-Score:3.40|P-value:1.68E-4 ID:SGTC_3327|Compound:9140648|FD-Score:4.38|P-value:1.91E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:18.20|P-value:3.24E-82 ID:SGTC_46|Compound:0329-0187a|FD-Score:5.55|P-value:2.26E-9 ID:SGTC_59|Compound:0330-0160|FD-Score:3.34|P-value:2.16E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:20.30|P-value:2.91E-102 ID:SGTC_67|Compound:0335-0847|FD-Score:15.30|P-value:7.10E-59 ID:SGTC_70|Compound:0141-0289|FD-Score:3.06|P-value:6.25E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:17.30|P-value:4.93E-75 ID:SGTC_87|Compound:0100-0052|FD-Score:4.55|P-value:7.73E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:4.79|P-value:2.11E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:4.20|P-value:4.68E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:10.40|P-value:2.76E-28 ID:SGTC_158|Compound:k038-0087|FD-Score:11.40|P-value:1.28E-33 ID:SGTC_163|Compound:1327-0036|FD-Score:3.51|P-value:1.06E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:6.26|P-value:2.00E-11 ID:SGTC_168|Compound:3970-0862|FD-Score:5.44|P-value:4.57E-9 ID:SGTC_195|Compound:4234-0266|FD-Score:3.38|P-value:1.77E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:5.85|P-value:3.20E-10 ID:SGTC_216|Compound:k038-0035|FD-Score:5.69|P-value:9.75E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:37.60|P-value:0 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.57|P-value:6.91E-7 ID:SGTC_294|Compound:k038-0071|FD-Score:4.85|P-value:1.56E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:3.32|P-value:2.31E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:6.04|P-value:8.80E-11 ID:SGTC_367|Compound:0335-0881|FD-Score:3.50|P-value:1.11E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:8.48|P-value:1.74E-19 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.32|P-value:2.29E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.21|P-value:3.58E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.58|P-value:6.52E-7 ID:SGTC_717|Compound:1532-0246|FD-Score:2.94|P-value:9.72E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:6.26|P-value:1.94E-11 ID:SGTC_824|Compound:1304-0008|FD-Score:4.33|P-value:2.46E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:3.01|P-value:7.37E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:5.20|P-value:2.02E-8 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.01|P-value:7.45E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:-3.96|P-value:1.45E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:-5.11|P-value:3.35E-8 ID:SGTC_1206|Compound:3978-0017|FD-Score:11.80|P-value:7.19E-36 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.05|P-value:6.41E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:5.64|P-value:1.27E-9 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.69|P-value:4.99E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:-2.95|P-value:8.91E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.85|P-value:2.44E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.51|P-value:1.03E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.68|P-value:5.05E-5 ID:SGTC_1627|Compound:st003713|FD-Score:4.29|P-value:2.95E-6 ID:SGTC_1635|Compound:st007035|FD-Score:21.50|P-value:9.95E-115 ID:SGTC_1638|Compound:st008370|FD-Score:3.17|P-value:4.18E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.53|P-value:9.59E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-4.98|P-value:6.94E-8 ID:SGTC_1801|Compound:st050089|FD-Score:-3.21|P-value:3.39E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-5.45|P-value:4.21E-9 ID:SGTC_1820|Compound:st053765|FD-Score:3.50|P-value:1.09E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-3.31|P-value:2.28E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-4.34|P-value:2.25E-6 ID:SGTC_2041|Compound:5107442|FD-Score:4.09|P-value:7.83E-6 ID:SGTC_2056|Compound:5235370|FD-Score:3.37|P-value:1.86E-4 ID:SGTC_2124|Compound:5246320|FD-Score:-3.30|P-value:2.39E-4 ID:SGTC_2358|Compound:9037157|FD-Score:2.99|P-value:7.92E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.24|P-value:3.13E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.33|P-value:2.15E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.97|P-value:8.29E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.55|P-value:2.22E-9 ID:SGTC_2585|Compound:alliin|FD-Score:3.16|P-value:4.25E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:2.96|P-value:8.82E-4 ID:SGTC_2796|Compound:7949634|FD-Score:5.69|P-value:9.23E-10 ID:SGTC_2799|Compound:7812892|FD-Score:-3.89|P-value:1.91E-5 ID:SGTC_2801|Compound:7907800|FD-Score:4.29|P-value:2.90E-6 ID:SGTC_2802|Compound:7925815|FD-Score:4.00|P-value:1.19E-5 ID:SGTC_2803|Compound:7707263|FD-Score:-3.55|P-value:8.76E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.40|P-value:1.61E-6 ID:SGTC_3118|Compound:9124250|FD-Score:3.40|P-value:1.68E-4 ID:SGTC_3327|Compound:9140648|FD-Score:4.38|P-value:1.91E-6

Top fitness defect scores for YOR125C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 37.60 5.3 µM 0 2 0
2 SGTC_1635 st007035 21.50 42.4 µM 9.95E-115 19 4.36E-103
3 SGTC_64 000l-0018 20.30 272.1 µM 2.91E-102 ubiquinone biosynthesis & proteasome 9 6.54E-92
4 SGTC_36 0335-0881 18.20 14.2 µM 3.24E-82 ubiquinone biosynthesis & proteasome 8 6.17E-74
5 SGTC_86 0417-1630 17.30 471.9 µM 4.93E-75 ubiquinone biosynthesis & proteasome 9 1.70E-67
6 SGTC_67 0335-0847 15.30 266.0 µM 7.10E-59 ubiquinone biosynthesis & proteasome 9 5.26E-53
7 SGTC_1206 3978-0017 11.80 132.0 µM 7.19E-36 ERG2 2 2.26E-32
8 SGTC_158 k038-0087 11.40 26.4 µM 1.28E-33 ubiquinone biosynthesis & proteasome 27 2.37E-30
9 SGTC_142 0335-0849 10.40 62.7 µM 2.76E-28 ubiquinone biosynthesis & proteasome 25 1.45E-25
10 SGTC_386 1509-0011 8.48 3.1 µM 1.74E-19 58 1.14E-17
11 SGTC_794 k038-0031 6.26 316.0 µM 1.94E-11 ubiquinone biosynthesis & proteasome 51 1.93E-10
12 SGTC_165 k038-0023 6.26 64.4 µM 2.00E-11 ubiquinone biosynthesis & proteasome 21 1.99E-10
13 SGTC_340 k038-0059 6.04 454.0 µM 8.80E-11 ubiquinone biosynthesis & proteasome 21 7.51E-10
14 SGTC_200 k038-0079 5.85 37.5 µM 3.20E-10 ubiquinone biosynthesis & proteasome 27 2.40E-9
15 SGTC_2796 7949634 5.69 45.5 µM 9.23E-10 5 6.22E-9
16 SGTC_216 k038-0035 5.69 28.4 µM 9.75E-10 ubiquinone biosynthesis & proteasome 26 6.53E-9
17 SGTC_1260 0700-1617 5.64 7.8 µM 1.27E-9 calcium & mitochondrial duress 11 8.28E-9
18 SGTC_46 0329-0187a 5.55 2.2 µM 2.26E-9 32 1.39E-8
19 SGTC_168 3970-0862 5.44 530.5 µM 4.57E-9 58 2.62E-8
20 SGTC_873 0591-4978 5.20 488.0 µM 2.02E-8 6 9.98E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.829 0 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.788 0 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.777 0 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.754 0 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.752 0 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.720 0 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.682 0 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.652 0 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.610 0 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.607 0 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.590 1.95E-313 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.578 1.41E-297 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.573 2.94E-291 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.559 1.38E-275 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.550 1.03E-264 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit