YOR132W / VPS17

Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR132W / VPS17

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:-3.33|P-value:3.99E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.14|P-value:7.78E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.87|P-value:4.82E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:4.39|P-value:5.03E-6 ID:SGTC_89|Compound:0302-0250|FD-Score:3.19|P-value:6.72E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:-4.05|P-value:2.34E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:5.43|P-value:2.26E-8 ID:SGTC_137|Compound:0438-0332|FD-Score:3.30|P-value:4.41E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.10|P-value:9.04E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.18|P-value:1.28E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:3.34|P-value:3.91E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.10|P-value:8.95E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:6.08|P-value:4.63E-10 ID:SGTC_227|Compound:fluconazole|FD-Score:11.10|P-value:2.71E-29 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.12|P-value:8.54E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:-3.26|P-value:5.28E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:4.26|P-value:8.95E-6 ID:SGTC_346|Compound:4513-0042|FD-Score:3.50|P-value:2.12E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:5.77|P-value:3.27E-9 ID:SGTC_380|Compound:3970-0968|FD-Score:3.15|P-value:7.51E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.59|P-value:1.89E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.39|P-value:3.28E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.45|P-value:2.56E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.84|P-value:2.07E-9 ID:SGTC_470|Compound:aa-861|FD-Score:-4.79|P-value:7.35E-7 ID:SGTC_486|Compound:niguldipine|FD-Score:3.46|P-value:2.47E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:4.46|P-value:3.51E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:4.96|P-value:2.97E-7 ID:SGTC_574|Compound:1315-0397|FD-Score:3.19|P-value:6.64E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:4.39|P-value:4.97E-6 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.19|P-value:6.53E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.24|P-value:5.55E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.20|P-value:6.34E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.29|P-value:4.69E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.81|P-value:6.40E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:3.53|P-value:1.91E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:3.28|P-value:4.89E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.12|P-value:8.33E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:-3.10|P-value:8.91E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:-4.20|P-value:1.17E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.84|P-value:5.56E-5 ID:SGTC_1159|Compound:4092-0538|FD-Score:5.12|P-value:1.29E-7 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.10|P-value:1.85E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.42|P-value:2.84E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.55|P-value:1.76E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.26|P-value:5.14E-4 ID:SGTC_1697|Compound:st025554|FD-Score:3.11|P-value:8.78E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.94|P-value:3.72E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.14|P-value:8.01E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.23|P-value:1.81E-10 ID:SGTC_1786|Compound:berberine|FD-Score:-3.09|P-value:9.28E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.36|P-value:3.60E-4 ID:SGTC_1820|Compound:st053765|FD-Score:4.13|P-value:1.61E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.05|P-value:6.63E-13 ID:SGTC_1942|Compound:st076330|FD-Score:4.64|P-value:1.52E-6 ID:SGTC_1988|Compound:st071872|FD-Score:3.60|P-value:1.45E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-4.41|P-value:4.56E-6 ID:SGTC_2086|Compound:5274770|FD-Score:3.95|P-value:3.51E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.88|P-value:4.81E-5 ID:SGTC_2147|Compound:5545932|FD-Score:3.62|P-value:1.33E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.09|P-value:1.93E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.09|P-value:9.45E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.61|P-value:1.41E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.12|P-value:8.47E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.98|P-value:3.11E-5 ID:SGTC_2339|Compound:9000433|FD-Score:5.59|P-value:9.07E-9 ID:SGTC_2380|Compound:9035439|FD-Score:3.91|P-value:4.11E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.38|P-value:3.39E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:5.70|P-value:4.86E-9 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.27|P-value:5.03E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.88|P-value:4.68E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.83|P-value:3.18E-12 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.12|P-value:8.39E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.48|P-value:2.29E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.31|P-value:4.25E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.34|P-value:6.28E-6 ID:SGTC_2792|Compound:7535235|FD-Score:3.12|P-value:8.32E-4 ID:SGTC_2896|Compound:9052656|FD-Score:7.06|P-value:5.94E-13 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.89|P-value:4.47E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-5.62|P-value:7.61E-9 ID:SGTC_3209|Compound:9113616|FD-Score:4.18|P-value:1.31E-5 ID:SGTC_3247|Compound:9135149|FD-Score:3.10|P-value:9.20E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.33|P-value:3.99E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.14|P-value:7.78E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.87|P-value:4.82E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:4.39|P-value:5.03E-6 ID:SGTC_89|Compound:0302-0250|FD-Score:3.19|P-value:6.72E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:-4.05|P-value:2.34E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:5.43|P-value:2.26E-8 ID:SGTC_137|Compound:0438-0332|FD-Score:3.30|P-value:4.41E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.10|P-value:9.04E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.18|P-value:1.28E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:3.34|P-value:3.91E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.10|P-value:8.95E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:6.08|P-value:4.63E-10 ID:SGTC_227|Compound:fluconazole|FD-Score:11.10|P-value:2.71E-29 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.12|P-value:8.54E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:-3.26|P-value:5.28E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:4.26|P-value:8.95E-6 ID:SGTC_346|Compound:4513-0042|FD-Score:3.50|P-value:2.12E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:5.77|P-value:3.27E-9 ID:SGTC_380|Compound:3970-0968|FD-Score:3.15|P-value:7.51E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.59|P-value:1.89E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.39|P-value:3.28E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.45|P-value:2.56E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.84|P-value:2.07E-9 ID:SGTC_470|Compound:aa-861|FD-Score:-4.79|P-value:7.35E-7 ID:SGTC_486|Compound:niguldipine|FD-Score:3.46|P-value:2.47E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:4.46|P-value:3.51E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:4.96|P-value:2.97E-7 ID:SGTC_574|Compound:1315-0397|FD-Score:3.19|P-value:6.64E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:4.39|P-value:4.97E-6 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.19|P-value:6.53E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.24|P-value:5.55E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.20|P-value:6.34E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.29|P-value:4.69E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.81|P-value:6.40E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:3.53|P-value:1.91E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:3.28|P-value:4.89E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.12|P-value:8.33E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:-3.10|P-value:8.91E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:-4.20|P-value:1.17E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.84|P-value:5.56E-5 ID:SGTC_1159|Compound:4092-0538|FD-Score:5.12|P-value:1.29E-7 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.10|P-value:1.85E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.42|P-value:2.84E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.55|P-value:1.76E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.26|P-value:5.14E-4 ID:SGTC_1697|Compound:st025554|FD-Score:3.11|P-value:8.78E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.94|P-value:3.72E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.14|P-value:8.01E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.23|P-value:1.81E-10 ID:SGTC_1786|Compound:berberine|FD-Score:-3.09|P-value:9.28E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.36|P-value:3.60E-4 ID:SGTC_1820|Compound:st053765|FD-Score:4.13|P-value:1.61E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.05|P-value:6.63E-13 ID:SGTC_1942|Compound:st076330|FD-Score:4.64|P-value:1.52E-6 ID:SGTC_1988|Compound:st071872|FD-Score:3.60|P-value:1.45E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-4.41|P-value:4.56E-6 ID:SGTC_2086|Compound:5274770|FD-Score:3.95|P-value:3.51E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.88|P-value:4.81E-5 ID:SGTC_2147|Compound:5545932|FD-Score:3.62|P-value:1.33E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.09|P-value:1.93E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.09|P-value:9.45E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.61|P-value:1.41E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.12|P-value:8.47E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.98|P-value:3.11E-5 ID:SGTC_2339|Compound:9000433|FD-Score:5.59|P-value:9.07E-9 ID:SGTC_2380|Compound:9035439|FD-Score:3.91|P-value:4.11E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.38|P-value:3.39E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:5.70|P-value:4.86E-9 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.27|P-value:5.03E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.88|P-value:4.68E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.83|P-value:3.18E-12 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.12|P-value:8.39E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.48|P-value:2.29E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.31|P-value:4.25E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.34|P-value:6.28E-6 ID:SGTC_2792|Compound:7535235|FD-Score:3.12|P-value:8.32E-4 ID:SGTC_2896|Compound:9052656|FD-Score:7.06|P-value:5.94E-13 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.89|P-value:4.47E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-5.62|P-value:7.61E-9 ID:SGTC_3209|Compound:9113616|FD-Score:4.18|P-value:1.31E-5 ID:SGTC_3247|Compound:9135149|FD-Score:3.10|P-value:9.20E-4

Top fitness defect scores for YOR132W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_227 fluconazole 11.10 33.5 µM 2.71E-29 azole & statin 13 5.98E-29
2 SGTC_2896 9052656 7.06 71.4 µM 5.94E-13 endomembrane recycling 27 8.22E-13
3 SGTC_1844 rapamycin 7.05 4.0 nM 6.63E-13 71 9.15E-13
4 SGTC_2679 rapamycin 6.83 1.0 nM 3.18E-12 62 4.30E-12
5 SGTC_168 3970-0862 6.08 530.5 µM 4.63E-10 39 5.91E-10
6 SGTC_377 3970-0964 5.77 33.1 µM 3.27E-9 19 4.07E-9
7 SGTC_2418 pentamidine 5.70 31.7 µM 4.86E-9 mitochondrial processes 17 6.02E-9
8 SGTC_2339 9000433 5.59 200.0 µM 9.07E-9 6 1.11E-8
9 SGTC_124 0136-0217 5.43 7.1 µM 2.26E-8 mitochondrial stress 28 2.75E-8
10 SGTC_1159 4092-0538 5.12 61.2 µM 1.29E-7 9 1.54E-7
11 SGTC_528 3492-0019 4.96 172.0 µM 2.97E-7 calcium & mitochondrial duress 157 3.50E-7
12 SGTC_1942 st076330 4.64 65.2 µM 1.52E-6 16 1.75E-6
13 SGTC_432 NS 1619 4.59 61.3 µM 1.89E-6 14 2.18E-6
14 SGTC_522 1273-0010 4.46 11.6 µM 3.51E-6 60S ribosome export 15 4.01E-6
15 SGTC_701 4424-0219 4.39 185.0 µM 4.97E-6 calcium & mitochondrial duress 16 5.66E-6
16 SGTC_86 0417-1630 4.39 471.9 µM 5.03E-6 ubiquinone biosynthesis & proteasome 128 5.73E-6
17 SGTC_2786 7743617 4.34 45.5 µM 6.28E-6 18 7.13E-6
18 SGTC_339 3091-4833 4.26 71.4 µM 8.95E-6 iron homeostasis 16 1.01E-5
19 SGTC_149 3970-0822 4.18 46.1 µM 1.28E-5 tubulin folding & SWR complex 85 1.44E-5
20 SGTC_3209 9113616 4.18 49.5 µM 1.31E-5 22 1.48E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.256 2.53E-51 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.224 3.00E-39 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.190 8.89E-29 YLR119W SRN2 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
0.188 3.81E-28 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.184 4.38E-27 YHR036W BRL1 het Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
0.183 1.15E-26 YGL113W SLD3 het Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress
0.169 6.18E-23 YPL084W BRO1 hom Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes
0.167 2.15E-22 YDL119C_p YDL119C_p hom Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
0.161 6.20E-21 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.160 1.32E-20 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.160 1.55E-20 YOR069W VPS5 hom Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes
0.159 1.86E-20 YGL252C RTG2 hom Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
0.158 2.63E-20 YOR068C VAM10 hom Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering
0.158 3.44E-20 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.150 2.84E-18 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6