HIPHOP chemogenomics database

YOR141C / ARP8

Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity

Zygosity: Homozygous strain

fixedexpanded
Profile for YOR141C / ARP8

Click on Significant Values for Screen Details

Top fitness defect scores for YOR141C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2617	dihydrotanshinone i	15.20	20.8 µM	2.26E-48	copper-dependent oxidative stress	1	1.21E-52
2	SGTC_800	3448-7362	12.00	155.0 µM	9.06E-31	translation	2	2.13E-33
3	SGTC_2582	agaric acid	9.63	100.0 µM	1.39E-20	redox potentiating	74	2.86E-22
4	SGTC_58	0957-0393	9.62	9.0 µM	1.63E-20	cell wall	89	3.39E-22
5	SGTC_143	4032-1194	6.05	15.7 µM	3.32E-9		19	7.38E-10
6	SGTC_212	3807-4682	5.77	38.8 µM	1.53E-8	tubulin folding & SWR complex	28	3.89E-9
7	SGTC_67	0335-0847	5.55	266.0 µM	4.97E-8	ubiquinone biosynthesis & proteasome	72	1.40E-8
8	SGTC_625	k213-0058	5.48	121.0 µM	7.18E-8	translation	48	2.10E-8
9	SGTC_2531	methyl deoxycholate	5.29	70.1 µM	1.90E-7		8	6.04E-8
10	SGTC_210	3551-0445	5.25	56.8 µM	2.29E-7		34	7.41E-8
11	SGTC_138	0850-0259	5.07	40.9 µM	5.55E-7	cell wall	141	1.94E-7
12	SGTC_2556	citropten	5.06	84.6 µM	5.87E-7		8	2.06E-7
13	SGTC_2716	st080858	5.04	38.6 µM	6.50E-7	60S ribosome export	5	2.30E-7
14	SGTC_1160	4092-0570	4.91	10.5 µM	1.19E-6	plasma membrane duress	23	4.46E-7
15	SGTC_304	1310-0298	4.76	97.0 µM	2.40E-6	cell wall	34	9.52E-7
16	SGTC_2651	1327-0036	4.71	5.0 µM	3.12E-6		126	1.26E-6
17	SGTC_1266	0828-0227	4.70	32.9 µM	3.24E-6		11	1.32E-6
18	SGTC_86	0417-1630	4.65	471.9 µM	3.94E-6	ubiquinone biosynthesis & proteasome	122	1.63E-6
19	SGTC_3266	9136860	4.63	49.5 µM	4.38E-6	cell wall	33	1.83E-6
20	SGTC_1707	st032323	4.49	6.3 µM	8.08E-6	DNA damage response	45	3.56E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.269	6.64E-57	YML103C	NUP188	hom	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.249	1.84E-48	YNL215W	IES2	hom	Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.230	1.42E-41	YLR331C_d	JIP3_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.214	3.51E-36	YAL015C	NTG1	hom	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.205	2.57E-33	YNL105W_d	RRT16_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.201	4.83E-32	YIL160C	POT1	hom	3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.197	8.12E-31	YJL069C	UTP18	het	Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
0.193	2.26E-29	YLR238W	FAR10	hom	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
0.187	1.06E-27	YOR231W	MKK1	hom	MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.184	5.66E-27	YNL106C	INP52	hom	Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.182	1.90E-26	YLL043W	FPS1	hom	Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.178	2.34E-25	YOL003C	PFA4	hom	Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.176	1.12E-24	YOR051C	ETT1	hom	Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough
0.176	1.25E-24	YDR205W	MSC2	hom	Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.175	2.00E-24	YKL076C_d	PSY1_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C