YOR142W / LSC1

Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR142W / LSC1

Click on Significant Values for Screen Details ID:SGTC_54|Compound:0159-0055|FD-Score:3.08|P-value:5.41E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.66|P-value:5.24E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.00|P-value:8.75E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.65|P-value:5.48E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.35|P-value:2.39E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.62|P-value:7.62E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.05|P-value:6.05E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-3.39|P-value:1.98E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.43|P-value:1.35E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.08|P-value:5.28E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.26|P-value:2.65E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.67|P-value:5.04E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:2.97|P-value:7.96E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.17|P-value:4.69E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.96|P-value:1.77E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:-4.42|P-value:1.92E-6 ID:SGTC_889|Compound:0919-1524|FD-Score:5.41|P-value:5.31E-9 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.60|P-value:8.41E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.38|P-value:2.09E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.47|P-value:1.42E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.76|P-value:3.36E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.02|P-value:8.26E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.36|P-value:1.83E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:5.74|P-value:6.37E-10 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.73|P-value:3.87E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:-6.87|P-value:2.87E-13 ID:SGTC_1240|Compound:0356-0016|FD-Score:2.98|P-value:7.69E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.93|P-value:1.55E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.53|P-value:9.13E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.28|P-value:2.48E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:2.93|P-value:9.10E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.33|P-value:2.03E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:5.23|P-value:1.57E-8 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.21|P-value:3.33E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.70|P-value:4.27E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.48|P-value:1.10E-4 ID:SGTC_1554|Compound:st069299|FD-Score:2.91|P-value:9.83E-4 ID:SGTC_1630|Compound:st005209|FD-Score:4.63|P-value:4.75E-7 ID:SGTC_1638|Compound:st008370|FD-Score:7.02|P-value:5.85E-14 ID:SGTC_1801|Compound:st050089|FD-Score:3.28|P-value:2.50E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.23|P-value:3.00E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.41|P-value:1.50E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-4.45|P-value:1.64E-6 ID:SGTC_2061|Compound:5245884|FD-Score:3.50|P-value:1.02E-4 ID:SGTC_2114|Compound:5491910|FD-Score:4.12|P-value:6.39E-6 ID:SGTC_2119|Compound:5528445|FD-Score:3.15|P-value:4.04E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.82|P-value:3.25E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.54|P-value:7.40E-7 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.25|P-value:2.81E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.49|P-value:1.08E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.62|P-value:6.18E-5 ID:SGTC_3123|Compound:9126162|FD-Score:-3.04|P-value:7.70E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:3.08|P-value:5.41E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.66|P-value:5.24E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.00|P-value:8.75E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.65|P-value:5.48E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.35|P-value:2.39E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.62|P-value:7.62E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.05|P-value:6.05E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-3.39|P-value:1.98E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.43|P-value:1.35E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.08|P-value:5.28E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.26|P-value:2.65E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.67|P-value:5.04E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:2.97|P-value:7.96E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.17|P-value:4.69E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.96|P-value:1.77E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:-4.42|P-value:1.92E-6 ID:SGTC_889|Compound:0919-1524|FD-Score:5.41|P-value:5.31E-9 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.60|P-value:8.41E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.38|P-value:2.09E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.47|P-value:1.42E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.76|P-value:3.36E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.02|P-value:8.26E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.36|P-value:1.83E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:5.74|P-value:6.37E-10 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.73|P-value:3.87E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:-6.87|P-value:2.87E-13 ID:SGTC_1240|Compound:0356-0016|FD-Score:2.98|P-value:7.69E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.93|P-value:1.55E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.53|P-value:9.13E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.28|P-value:2.48E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:2.93|P-value:9.10E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.33|P-value:2.03E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:5.23|P-value:1.57E-8 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.21|P-value:3.33E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.70|P-value:4.27E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.48|P-value:1.10E-4 ID:SGTC_1554|Compound:st069299|FD-Score:2.91|P-value:9.83E-4 ID:SGTC_1630|Compound:st005209|FD-Score:4.63|P-value:4.75E-7 ID:SGTC_1638|Compound:st008370|FD-Score:7.02|P-value:5.85E-14 ID:SGTC_1801|Compound:st050089|FD-Score:3.28|P-value:2.50E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.23|P-value:3.00E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.41|P-value:1.50E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-4.45|P-value:1.64E-6 ID:SGTC_2061|Compound:5245884|FD-Score:3.50|P-value:1.02E-4 ID:SGTC_2114|Compound:5491910|FD-Score:4.12|P-value:6.39E-6 ID:SGTC_2119|Compound:5528445|FD-Score:3.15|P-value:4.04E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.82|P-value:3.25E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.54|P-value:7.40E-7 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.25|P-value:2.81E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.49|P-value:1.08E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.62|P-value:6.18E-5 ID:SGTC_3123|Compound:9126162|FD-Score:-3.04|P-value:7.70E-4

Top fitness defect scores for YOR142W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1638 st008370 7.02 60.6 µM 5.85E-14 ergosterol biosynthesis 8 1.11E-12
2 SGTC_1103 duloxetine 5.74 36.1 µM 6.37E-10 3 4.77E-9
3 SGTC_889 0919-1524 5.41 82.7 µM 5.31E-9 2 3.22E-8
4 SGTC_1383 3049-0032 5.23 20.7 µM 1.57E-8 60S ribosome export 6 8.56E-8
5 SGTC_1630 st005209 4.63 31.3 µM 4.75E-7 13 1.84E-6
6 SGTC_2538 3',7'-epoxycaryophyllan-6-one 4.54 100.0 µM 7.40E-7 16 2.75E-6
7 SGTC_2114 5491910 4.12 81.2 µM 6.39E-6 6 1.92E-5
8 SGTC_1246 0422-0085 3.93 105.0 µM 1.55E-5 31 4.27E-5
9 SGTC_927 2425-1185 3.76 123.0 µM 3.36E-5 32 8.56E-5
10 SGTC_1181 1222-0449 3.73 220.0 µM 3.87E-5 31 9.71E-5
11 SGTC_1476 4112-3294 3.70 3.3 µM 4.27E-5 60S ribosome export 25 1.06E-4
12 SGTC_807 1315-0151 3.67 48.0 µM 5.04E-5 38 1.23E-4
13 SGTC_67 0335-0847 3.66 266.0 µM 5.24E-5 ubiquinone biosynthesis & proteasome 135 1.28E-4
14 SGTC_245 methotrexate 3.65 289.6 µM 5.48E-5 51 1.33E-4
15 SGTC_2815 7968870 3.62 71.4 µM 6.18E-5 34 1.48E-4
16 SGTC_1251 0490-5699 3.53 265.0 µM 9.13E-5 51 2.10E-4
17 SGTC_2061 5245884 3.50 81.0 µM 1.02E-4 tubulin folding & SWR complex 35 2.33E-4
18 SGTC_2809 7964133 3.49 13.0 µM 1.08E-4 60S ribosome export 59 2.45E-4
19 SGTC_1535 tetrahydropapaveroline hydrobromide 3.48 54.3 µM 1.10E-4 RPP1 & pyrimidine depletion 23 2.48E-4
20 SGTC_726 3448-4391 3.43 34.2 µM 1.35E-4 29 2.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.29E-11 YLL057C JLP1 hom Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation
0.101 4.58E-9 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.100 1.31E-8 YKR099W BAS1 hom Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
0.099 7.88E-9 YIL152W_p YIL152W_p hom Putative protein of unknown function
0.094 4.55E-8 YJR003C_p YJR003C_p hom Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis
0.093 6.26E-8 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.092 1.00E-7 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.088 3.19E-7 YDL035C GPR1 hom Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis
0.087 4.74E-7 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.080 3.12E-6 YNL181W_p YNL181W_p het Putative oxidoreductase; required for cell viability
0.078 5.54E-6 YMR272W-B_p YMR272W-B_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.078 5.61E-6 YDL182W LYS20 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication
0.078 6.52E-6 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.077 7.82E-6 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.076 1.11E-5 YJL130C URA2 hom Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP