YOR152C_p

Putative protein of unknown function; YOR152C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR152C / YOR152C

Click on Significant Values for Screen Details ID:SGTC_316|Compound:k060-0003|FD-Score:3.01|P-value:3.22E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.86|P-value:9.08E-6 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.33|P-value:1.12E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-2.97|P-value:5.04E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-3.40|P-value:8.02E-5 ID:SGTC_499|Compound:genistein|FD-Score:-3.69|P-value:2.11E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:3.11|P-value:2.06E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:2.82|P-value:6.84E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-4.16|P-value:1.89E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-4.22|P-value:1.36E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.14|P-value:3.81E-12 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.87|P-value:2.93E-8 ID:SGTC_1499|Compound:4480-0877|FD-Score:2.77|P-value:8.27E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.91|P-value:1.49E-8 ID:SGTC_2236|Compound:dapsone|FD-Score:-3.30|P-value:1.25E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.19|P-value:2.04E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.64|P-value:1.89E-5 ID:SGTC_2349|Compound:9023730|FD-Score:2.81|P-value:7.19E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-4.90|P-value:2.48E-8 ID:SGTC_2393|Compound:9031399|FD-Score:2.93|P-value:4.48E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-2.91|P-value:6.31E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.40|P-value:5.78E-5 ID:SGTC_2815|Compound:7968870|FD-Score:-2.96|P-value:5.24E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.87|P-value:8.69E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-3.11|P-value:2.83E-4 ID:SGTC_3342|Compound:9147791|FD-Score:2.91|P-value:4.81E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.04|P-value:2.82E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-3.51|P-value:4.95E-5 ID:SGTC_316|Compound:k060-0003|FD-Score:3.01|P-value:3.22E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.86|P-value:9.08E-6 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.33|P-value:1.12E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-2.97|P-value:5.04E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-3.40|P-value:8.02E-5 ID:SGTC_499|Compound:genistein|FD-Score:-3.69|P-value:2.11E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:3.11|P-value:2.06E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:2.82|P-value:6.84E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-4.16|P-value:1.89E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-4.22|P-value:1.36E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.14|P-value:3.81E-12 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.87|P-value:2.93E-8 ID:SGTC_1499|Compound:4480-0877|FD-Score:2.77|P-value:8.27E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.91|P-value:1.49E-8 ID:SGTC_2236|Compound:dapsone|FD-Score:-3.30|P-value:1.25E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.19|P-value:2.04E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.64|P-value:1.89E-5 ID:SGTC_2349|Compound:9023730|FD-Score:2.81|P-value:7.19E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-4.90|P-value:2.48E-8 ID:SGTC_2393|Compound:9031399|FD-Score:2.93|P-value:4.48E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-2.91|P-value:6.31E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.40|P-value:5.78E-5 ID:SGTC_2815|Compound:7968870|FD-Score:-2.96|P-value:5.24E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.87|P-value:8.69E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-3.11|P-value:2.83E-4 ID:SGTC_3342|Compound:9147791|FD-Score:2.91|P-value:4.81E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.04|P-value:2.82E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-3.51|P-value:4.95E-5

Top fitness defect scores for YOR152C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2014 4013930 4.91 200.0 µM 1.49E-8 10 4.65E-7
2 SGTC_2340 7987427 3.64 183.4 µM 1.89E-5 49 1.38E-4
3 SGTC_2693 st077581 3.40 40.7 µM 5.78E-5 63 3.36E-4
4 SGTC_534 k292-0788 3.11 63.4 µM 2.06E-4 mitochondrial processes 59 9.24E-4
5 SGTC_3345 9148410 3.04 3.6 µM 2.82E-4 30 0.00119
6 SGTC_316 k060-0003 3.01 58.6 µM 3.22E-4 43 0.00132
7 SGTC_2393 9031399 2.93 185.9 µM 4.48E-4 RNA processing & uracil transport 79 0.00172
8 SGTC_3342 9147791 2.91 14.5 µM 4.81E-4 56 0.00182
9 SGTC_882 0843-0131 2.82 351.0 µM 6.84E-4 73 0.00242
10 SGTC_2349 9023730 2.81 187.1 µM 7.19E-4 98 0.00251
11 SGTC_1499 4480-0877 2.77 67.3 µM 8.27E-4 42 0.00281
12 SGTC_535 2293-4129 2.65 48.2 µM 0.00131 NEO1 161 0.00405
13 SGTC_935 2996-0153 2.61 430.0 µM 0.00151 PDR1 102 0.00455
14 SGTC_1725 st036284 2.57 20.6 µM 0.00172 121 0.00506
15 SGTC_2569 tetrandrine 2.56 100.0 µM 0.00179 108 0.00522
16 SGTC_3265 9137266 2.51 49.5 µM 0.00213 76 0.00601
17 SGTC_1262 0737-0114 2.48 49.6 µM 0.00238 134 0.00657
18 SGTC_2341 7987486 2.47 176.7 µM 0.00248 132 0.00677
19 SGTC_408 cantharidin 2.45 100.0 µM 0.00263 cell wall signaling 129 0.00711
20 SGTC_996 3970-0799 2.43 1.8 µM 0.00282 255 0.00751

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.362 1.49E-104 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.351 3.78E-98 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.342 1.63E-92 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.333 1.73E-87 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.306 4.18E-73 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.304 1.26E-72 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.290 4.66E-66 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.281 6.72E-62 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.279 5.66E-61 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.278 1.95E-60 YJR153W PGU1 hom Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
0.273 3.21E-58 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.272 3.74E-58 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.270 3.78E-57 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.263 3.90E-54 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.258 3.89E-52 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus