YOR155C / ISN1

Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR155C / ISN1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:6.69|P-value:3.21E-12 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-3.05|P-value:8.16E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.19|P-value:5.44E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.65|P-value:8.26E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.90|P-value:2.86E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:-3.72|P-value:6.23E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.16|P-value:6.00E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.38|P-value:2.40E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.05|P-value:9.01E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.26|P-value:5.61E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-7.78|P-value:5.69E-16 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-3.14|P-value:5.87E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.57|P-value:1.41E-6 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.36|P-value:2.85E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.55|P-value:1.38E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.74|P-value:6.37E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.92|P-value:2.65E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.46|P-value:2.37E-6 ID:SGTC_2942|Compound:9052777|FD-Score:4.31|P-value:4.93E-6 ID:SGTC_2943|Compound:9068529|FD-Score:3.65|P-value:8.98E-5 ID:SGTC_2945|Compound:9067681|FD-Score:3.32|P-value:3.32E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.15|P-value:5.77E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.79|P-value:4.60E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:6.69|P-value:3.21E-12 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-3.05|P-value:8.16E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.19|P-value:5.44E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.65|P-value:8.26E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.90|P-value:2.86E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:-3.72|P-value:6.23E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.16|P-value:6.00E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.38|P-value:2.40E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.05|P-value:9.01E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.26|P-value:5.61E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-7.78|P-value:5.69E-16 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-3.14|P-value:5.87E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.57|P-value:1.41E-6 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.36|P-value:2.85E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.55|P-value:1.38E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.74|P-value:6.37E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.92|P-value:2.65E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.46|P-value:2.37E-6 ID:SGTC_2942|Compound:9052777|FD-Score:4.31|P-value:4.93E-6 ID:SGTC_2943|Compound:9068529|FD-Score:3.65|P-value:8.98E-5 ID:SGTC_2945|Compound:9067681|FD-Score:3.32|P-value:3.32E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.15|P-value:5.77E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.79|P-value:4.60E-5

Top fitness defect scores for YOR155C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_6 0844-0013 6.69 19.8 µM 3.21E-12 8 1.10E-11
2 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.57 3.7 µM 1.41E-6 44 2.48E-6
3 SGTC_2755 lomerizine 4.46 42.7 µM 2.37E-6 19 4.08E-6
4 SGTC_2942 9052777 4.31 62.2 µM 4.93E-6 27 8.16E-6
5 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 3.74 100.0 µM 6.37E-5 25 9.29E-5
6 SGTC_2943 9068529 3.65 45.3 µM 8.98E-5 25 1.29E-4
7 SGTC_2607 solasodine 3.55 47.4 µM 1.38E-4 75 1.93E-4
8 SGTC_2587 piperic acid 3.36 92.2 µM 2.85E-4 38 3.86E-4
9 SGTC_2945 9067681 3.32 61.8 µM 3.32E-4 27 4.48E-4
10 SGTC_1013 4112-3890 3.19 241.0 µM 5.44E-4 TSC3-RPN4 71 7.16E-4
11 SGTC_1043 0916-0009 3.16 19.3 µM 6.00E-4 56 7.85E-4
12 SGTC_1442 4112-3290 3.05 3.0 µM 9.01E-4 48 0.00116
13 SGTC_1942 st076330 2.96 65.2 µM 0.00120 76 0.00152
14 SGTC_1144 3486-0183 2.90 12.5 µM 0.00148 72 0.00186
15 SGTC_3258 9138477 2.88 49.5 µM 0.00159 50 0.00199
16 SGTC_1779 st039427 2.83 55.0 µM 0.00188 100 0.00233
17 SGTC_2952 9073731 2.80 13.8 µM 0.00206 tubulin folding & SWR complex 114 0.00254
18 SGTC_1330 1469-0054 2.74 61.8 µM 0.00251 iron homeostasis 71 0.00307
19 SGTC_2062 5245942 2.71 200.0 µM 0.00276 90 0.00336
20 SGTC_1588 farnesol 2.64 29.9 µM 0.00340 79 0.00410

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.242 6.77E-46 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.184 4.59E-27 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.180 1.01E-25 YGL037C PNC1 hom Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress
0.179 1.27E-25 YLR398C SKI2 hom Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
0.176 7.84E-25 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.171 2.31E-23 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.167 2.06E-22 YOR220W RCN2 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress
0.165 5.73E-22 YDR100W TVP15 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
0.165 7.96E-22 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.158 2.94E-20 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress
0.155 1.30E-19 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.152 8.12E-19 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.152 8.53E-19 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.151 1.08E-18 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.150 2.37E-18 YJR037W_d YJR037W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces