YOR163W / DDP1

Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR163W / DDP1

Click on Significant Values for Screen Details ID:SGTC_350|Compound:k064-0020|FD-Score:3.05|P-value:5.42E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.07|P-value:5.10E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:5.26|P-value:8.98E-9 ID:SGTC_424|Compound:splitomicin|FD-Score:3.36|P-value:1.57E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.03|P-value:6.49E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.57|P-value:6.60E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.78|P-value:2.88E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:3.22|P-value:2.78E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.84|P-value:1.94E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:3.18|P-value:3.24E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.88|P-value:1.67E-5 ID:SGTC_987|Compound:1497-1013|FD-Score:2.98|P-value:7.02E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.08|P-value:4.76E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.60|P-value:5.84E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:-3.62|P-value:6.05E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.85|P-value:2.12E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.74|P-value:3.12E-5 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.09|P-value:4.58E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.73|P-value:3.18E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:3.00|P-value:6.53E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:2.93|P-value:8.55E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:4.03|P-value:7.97E-6 ID:SGTC_1690|Compound:st023502|FD-Score:3.02|P-value:6.05E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-4.59|P-value:5.07E-7 ID:SGTC_1836|Compound:st055642|FD-Score:3.25|P-value:2.45E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-2.92|P-value:9.53E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.70|P-value:2.77E-7 ID:SGTC_1983|Compound:st071813|FD-Score:3.18|P-value:3.27E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.37|P-value:1.68E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-3.63|P-value:5.68E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.09|P-value:4.60E-4 ID:SGTC_2264|Compound:7948757|FD-Score:-3.64|P-value:5.44E-5 ID:SGTC_2347|Compound:9049783|FD-Score:2.90|P-value:9.45E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:3.15|P-value:3.66E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.07|P-value:4.99E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-2.97|P-value:7.89E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-2.92|P-value:9.69E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.32|P-value:1.86E-4 ID:SGTC_2877|Compound:9040724|FD-Score:-3.46|P-value:1.16E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-3.01|P-value:6.85E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.05|P-value:5.42E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.07|P-value:5.10E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:5.26|P-value:8.98E-9 ID:SGTC_424|Compound:splitomicin|FD-Score:3.36|P-value:1.57E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.03|P-value:6.49E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.57|P-value:6.60E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.78|P-value:2.88E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:3.22|P-value:2.78E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.84|P-value:1.94E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:3.18|P-value:3.24E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.88|P-value:1.67E-5 ID:SGTC_987|Compound:1497-1013|FD-Score:2.98|P-value:7.02E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.08|P-value:4.76E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.60|P-value:5.84E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:-3.62|P-value:6.05E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.85|P-value:2.12E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.74|P-value:3.12E-5 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.09|P-value:4.58E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.73|P-value:3.18E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:3.00|P-value:6.53E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:2.93|P-value:8.55E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:4.03|P-value:7.97E-6 ID:SGTC_1690|Compound:st023502|FD-Score:3.02|P-value:6.05E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-4.59|P-value:5.07E-7 ID:SGTC_1836|Compound:st055642|FD-Score:3.25|P-value:2.45E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-2.92|P-value:9.53E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.70|P-value:2.77E-7 ID:SGTC_1983|Compound:st071813|FD-Score:3.18|P-value:3.27E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.37|P-value:1.68E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-3.63|P-value:5.68E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.09|P-value:4.60E-4 ID:SGTC_2264|Compound:7948757|FD-Score:-3.64|P-value:5.44E-5 ID:SGTC_2347|Compound:9049783|FD-Score:2.90|P-value:9.45E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:3.15|P-value:3.66E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.07|P-value:4.99E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-2.97|P-value:7.89E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-2.92|P-value:9.69E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.32|P-value:1.86E-4 ID:SGTC_2877|Compound:9040724|FD-Score:-3.46|P-value:1.16E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-3.01|P-value:6.85E-4

Top fitness defect scores for YOR163W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_378 3970-0959 5.26 8.3 µM 8.98E-9 4 7.06E-8
2 SGTC_1570 verbenone 4.03 133.0 µM 7.97E-6 15 2.78E-5
3 SGTC_986 1493-0483 3.88 84.0 µM 1.67E-5 12 5.32E-5
4 SGTC_729 4092-0585 3.84 94.1 µM 1.94E-5 26 6.08E-5
5 SGTC_1186 1319-0216 3.74 26.0 µM 3.12E-5 23 9.25E-5
6 SGTC_1489 4065-0444 3.73 182.0 µM 3.18E-5 23 9.41E-5
7 SGTC_1068 loratadine 3.60 26.9 µM 5.84E-5 35 1.61E-4
8 SGTC_606 k015-0008 3.57 38.6 µM 6.60E-5 27 1.79E-4
9 SGTC_424 splitomicin 3.36 100.0 mM 1.57E-4 39 3.84E-4
10 SGTC_2716 st080858 3.32 38.6 µM 1.86E-4 60S ribosome export 35 4.47E-4
11 SGTC_1836 st055642 3.25 81.0 µM 2.45E-4 49 5.68E-4
12 SGTC_634 1611-4317 3.22 11.2 µM 2.78E-4 ERG2 39 6.36E-4
13 SGTC_898 1000-0849 3.18 28.3 µM 3.24E-4 24 7.28E-4
14 SGTC_1983 st071813 3.18 46.9 µM 3.27E-4 RPP1 & pyrimidine depletion 46 7.34E-4
15 SGTC_2550 chrysin dimethyl ether 3.15 71.9 µM 3.66E-4 21 8.11E-4
16 SGTC_1413 3910-0535 3.09 34.4 µM 4.58E-4 40 9.88E-4
17 SGTC_2125 5246583 3.09 200.0 µM 4.60E-4 tubulin folding & SWR complex 94 9.92E-4
18 SGTC_1013 4112-3890 3.08 241.0 µM 4.76E-4 TSC3-RPN4 80 0.00102
19 SGTC_2620 irigenin 3.07 100.0 µM 4.99E-4 75 0.00107
20 SGTC_372 0155-0182 3.07 15.9 µM 5.10E-4 mitochondrial response to ROS 72 0.00109

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.193 1.65E-29 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.185 3.97E-27 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.168 1.22E-22 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.161 5.79E-21 YMR095C SNO1 hom Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
0.158 3.96E-20 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.151 1.24E-18 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.146 1.79E-17 YAL068C PAU8 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
0.136 2.64E-15 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.134 7.09E-15 YIR004W DJP1 hom Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ
0.132 1.53E-14 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.132 1.62E-14 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.131 3.09E-14 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.130 3.97E-14 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.128 8.09E-14 YNL078W NIS1 hom Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
0.128 1.21E-13 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene