YOR165W / SEY1

Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR165W / SEY1

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.55|P-value:2.09E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:6.63|P-value:1.92E-11 ID:SGTC_93|Compound:0109-0045|FD-Score:3.72|P-value:1.07E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.35|P-value:7.45E-6 ID:SGTC_121|Compound:0557-0495|FD-Score:3.47|P-value:2.80E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:15.30|P-value:9.17E-53 ID:SGTC_142|Compound:0335-0849|FD-Score:4.31|P-value:9.01E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:3.39|P-value:3.74E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.54|P-value:2.17E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.68|P-value:1.27E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.15|P-value:7.69E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.60|P-value:1.76E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.41|P-value:3.51E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:4.38|P-value:6.69E-6 ID:SGTC_806|Compound:3966-4455|FD-Score:3.23|P-value:6.65E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.78|P-value:8.53E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:3.26|P-value:6.09E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:-3.12|P-value:8.47E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.76|P-value:9.26E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:3.56|P-value:2.03E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.59|P-value:1.80E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.35|P-value:7.48E-6 ID:SGTC_1048|Compound:3161-0300|FD-Score:6.74|P-value:9.20E-12 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.84|P-value:7.27E-7 ID:SGTC_1060|Compound:3448-7350|FD-Score:-3.91|P-value:4.31E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.69|P-value:1.04E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.64|P-value:1.95E-6 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.79|P-value:8.06E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.16|P-value:8.40E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.45|P-value:4.78E-6 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.13|P-value:8.24E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-3.88|P-value:4.87E-5 ID:SGTC_1714|Compound:st033236|FD-Score:-3.70|P-value:9.99E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.51|P-value:2.47E-4 ID:SGTC_1856|Compound:st057054|FD-Score:6.98|P-value:1.72E-12 ID:SGTC_1895|Compound:st058434|FD-Score:3.23|P-value:6.76E-4 ID:SGTC_2063|Compound:5246145|FD-Score:7.01|P-value:1.44E-12 ID:SGTC_2069|Compound:5228469|FD-Score:4.43|P-value:5.10E-6 ID:SGTC_2127|Compound:5253358|FD-Score:5.31|P-value:6.04E-8 ID:SGTC_2155|Compound:5570423|FD-Score:3.52|P-value:2.33E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.74|P-value:1.00E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.26|P-value:1.15E-5 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:4.10|P-value:2.30E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.68|P-value:1.25E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.83|P-value:6.04E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.39|P-value:3.28E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.03|P-value:3.07E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:3.55|P-value:2.12E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.36|P-value:4.16E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.10|P-value:9.14E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.20|P-value:7.48E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.20|P-value:7.40E-4 ID:SGTC_2903|Compound:5923464|FD-Score:3.14|P-value:9.17E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.46|P-value:2.91E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.25|P-value:6.20E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.21|P-value:7.11E-4 ID:SGTC_3292|Compound:9120825|FD-Score:6.91|P-value:2.76E-12 ID:SGTC_25|Compound:0118-0223|FD-Score:3.55|P-value:2.09E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:6.63|P-value:1.92E-11 ID:SGTC_93|Compound:0109-0045|FD-Score:3.72|P-value:1.07E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.35|P-value:7.45E-6 ID:SGTC_121|Compound:0557-0495|FD-Score:3.47|P-value:2.80E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:15.30|P-value:9.17E-53 ID:SGTC_142|Compound:0335-0849|FD-Score:4.31|P-value:9.01E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:3.39|P-value:3.74E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.54|P-value:2.17E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.68|P-value:1.27E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.15|P-value:7.69E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.60|P-value:1.76E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.41|P-value:3.51E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:4.38|P-value:6.69E-6 ID:SGTC_806|Compound:3966-4455|FD-Score:3.23|P-value:6.65E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.78|P-value:8.53E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:3.26|P-value:6.09E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:-3.12|P-value:8.47E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.76|P-value:9.26E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:3.56|P-value:2.03E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.59|P-value:1.80E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.35|P-value:7.48E-6 ID:SGTC_1048|Compound:3161-0300|FD-Score:6.74|P-value:9.20E-12 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.84|P-value:7.27E-7 ID:SGTC_1060|Compound:3448-7350|FD-Score:-3.91|P-value:4.31E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.69|P-value:1.04E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.64|P-value:1.95E-6 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.79|P-value:8.06E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.16|P-value:8.40E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.45|P-value:4.78E-6 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.13|P-value:8.24E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-3.88|P-value:4.87E-5 ID:SGTC_1714|Compound:st033236|FD-Score:-3.70|P-value:9.99E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.51|P-value:2.47E-4 ID:SGTC_1856|Compound:st057054|FD-Score:6.98|P-value:1.72E-12 ID:SGTC_1895|Compound:st058434|FD-Score:3.23|P-value:6.76E-4 ID:SGTC_2063|Compound:5246145|FD-Score:7.01|P-value:1.44E-12 ID:SGTC_2069|Compound:5228469|FD-Score:4.43|P-value:5.10E-6 ID:SGTC_2127|Compound:5253358|FD-Score:5.31|P-value:6.04E-8 ID:SGTC_2155|Compound:5570423|FD-Score:3.52|P-value:2.33E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.74|P-value:1.00E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.26|P-value:1.15E-5 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:4.10|P-value:2.30E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.68|P-value:1.25E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.83|P-value:6.04E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.39|P-value:3.28E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.03|P-value:3.07E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:3.55|P-value:2.12E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.36|P-value:4.16E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.10|P-value:9.14E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.20|P-value:7.48E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.20|P-value:7.40E-4 ID:SGTC_2903|Compound:5923464|FD-Score:3.14|P-value:9.17E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.46|P-value:2.91E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.25|P-value:6.20E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.21|P-value:7.11E-4 ID:SGTC_3292|Compound:9120825|FD-Score:6.91|P-value:2.76E-12

Top fitness defect scores for YOR165W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_137 0438-0332 15.30 85.4 µM 9.17E-53 ubiquinone biosynthesis & proteasome 13 6.06E-53
2 SGTC_2063 5246145 7.01 200.0 µM 1.44E-12 3 1.22E-12
3 SGTC_1856 st057054 6.98 55.7 µM 1.72E-12 2 1.46E-12
4 SGTC_3292 9120825 6.91 59.8 µM 2.76E-12 2 2.34E-12
5 SGTC_1048 3161-0300 6.74 24.5 µM 9.20E-12 1 7.86E-12
6 SGTC_86 0417-1630 6.63 471.9 µM 1.92E-11 ubiquinone biosynthesis & proteasome 78 1.65E-11
7 SGTC_2127 5253358 5.31 187.9 µM 6.04E-8 5 5.35E-8
8 SGTC_1051 3253-3903 4.84 78.0 µM 7.27E-7 6 6.51E-7
9 SGTC_1161 k007-0610 4.64 110.0 µM 1.95E-6 ERAD & cell cycle 92 1.75E-6
10 SGTC_1326 1431-2094 4.45 10.8 µM 4.78E-6 tubulin folding & SWR complex 26 4.32E-6
11 SGTC_2069 5228469 4.43 200.0 µM 5.10E-6 7 4.61E-6
12 SGTC_653 0203-0016 4.38 55.2 µM 6.69E-6 7 6.05E-6
13 SGTC_103 0844-0104 4.35 51.8 µM 7.45E-6 ERAD & cell cycle 125 6.75E-6
14 SGTC_1024 4507-0395 4.35 26.0 µM 7.48E-6 TSC3-RPN4 18 6.77E-6
15 SGTC_142 0335-0849 4.31 62.7 µM 9.01E-6 ubiquinone biosynthesis & proteasome 108 8.17E-6
16 SGTC_2405 ticlatone 4.26 3.5 µM 1.15E-5 60 1.04E-5
17 SGTC_2558 carylophyllene oxide 4.10 100.0 µM 2.30E-5 10 2.10E-5
18 SGTC_2651 1327-0036 4.03 5.0 µM 3.07E-5 153 2.80E-5
19 SGTC_1186 1319-0216 3.79 26.0 µM 8.06E-5 21 7.40E-5
20 SGTC_883 0850-0245 3.78 24.6 µM 8.53E-5 cell wall 35 7.82E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.286 3.68E-64 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.265 8.60E-55 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.261 3.85E-53 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.258 5.03E-52 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.239 1.05E-44 YIL090W ICE2 hom Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
0.228 6.26E-41 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.222 8.71E-39 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.222 1.18E-38 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.212 2.76E-35 YDR086C SSS1 het Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
0.210 6.47E-35 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.207 7.85E-34 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.205 4.85E-33 YPL181W CTI6 hom Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
0.202 2.27E-32 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.201 8.32E-32 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.200 1.77E-31 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA