YOR170W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR170W / YOR170W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-4.53|P-value:3.12E-6 ID:SGTC_98|Compound:0074-0023|FD-Score:3.56|P-value:1.95E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.76|P-value:9.95E-7 ID:SGTC_378|Compound:3970-0959|FD-Score:3.20|P-value:7.21E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:6.33|P-value:1.36E-10 ID:SGTC_513|Compound:4245-1575|FD-Score:3.57|P-value:1.87E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.18|P-value:7.60E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.21|P-value:6.96E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.17|P-value:7.79E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.66|P-value:1.33E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.58|P-value:1.83E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.25|P-value:5.83E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.11|P-value:9.50E-4 ID:SGTC_1656|Compound:st012921|FD-Score:4.76|P-value:1.04E-6 ID:SGTC_1865|Compound:st057639|FD-Score:3.68|P-value:1.23E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.97|P-value:3.75E-5 ID:SGTC_1960|Compound:st011366|FD-Score:3.61|P-value:1.58E-4 ID:SGTC_2022|Compound:5136654|FD-Score:4.07|P-value:2.51E-5 ID:SGTC_2034|Compound:5197015|FD-Score:-4.91|P-value:4.85E-7 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.47|P-value:2.73E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.55|P-value:2.79E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.69|P-value:1.14E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.17|P-value:7.77E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.77|P-value:8.71E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.10|P-value:9.92E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.75|P-value:9.00E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:3.83|P-value:6.69E-5 ID:SGTC_2714|Compound:st079313|FD-Score:3.22|P-value:6.69E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.63|P-value:1.45E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:3.64|P-value:1.45E-4 ID:SGTC_2877|Compound:9040724|FD-Score:-3.30|P-value:4.90E-4 ID:SGTC_2881|Compound:9058953|FD-Score:5.43|P-value:3.13E-8 ID:SGTC_2896|Compound:9052656|FD-Score:-8.70|P-value:2.00E-18 ID:SGTC_2959|Compound:9079155|FD-Score:3.88|P-value:5.47E-5 ID:SGTC_3190|Compound:9110366|FD-Score:-3.66|P-value:1.29E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-4.78|P-value:9.28E-7 ID:SGTC_3263|Compound:9137018|FD-Score:-3.24|P-value:6.04E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.79|P-value:8.04E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.53|P-value:3.12E-6 ID:SGTC_98|Compound:0074-0023|FD-Score:3.56|P-value:1.95E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.76|P-value:9.95E-7 ID:SGTC_378|Compound:3970-0959|FD-Score:3.20|P-value:7.21E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:6.33|P-value:1.36E-10 ID:SGTC_513|Compound:4245-1575|FD-Score:3.57|P-value:1.87E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.18|P-value:7.60E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.21|P-value:6.96E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.17|P-value:7.79E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.66|P-value:1.33E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.58|P-value:1.83E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.25|P-value:5.83E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.11|P-value:9.50E-4 ID:SGTC_1656|Compound:st012921|FD-Score:4.76|P-value:1.04E-6 ID:SGTC_1865|Compound:st057639|FD-Score:3.68|P-value:1.23E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.97|P-value:3.75E-5 ID:SGTC_1960|Compound:st011366|FD-Score:3.61|P-value:1.58E-4 ID:SGTC_2022|Compound:5136654|FD-Score:4.07|P-value:2.51E-5 ID:SGTC_2034|Compound:5197015|FD-Score:-4.91|P-value:4.85E-7 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.47|P-value:2.73E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.55|P-value:2.79E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.69|P-value:1.14E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.17|P-value:7.77E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.77|P-value:8.71E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.10|P-value:9.92E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.75|P-value:9.00E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:3.83|P-value:6.69E-5 ID:SGTC_2714|Compound:st079313|FD-Score:3.22|P-value:6.69E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.63|P-value:1.45E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:3.64|P-value:1.45E-4 ID:SGTC_2877|Compound:9040724|FD-Score:-3.30|P-value:4.90E-4 ID:SGTC_2881|Compound:9058953|FD-Score:5.43|P-value:3.13E-8 ID:SGTC_2896|Compound:9052656|FD-Score:-8.70|P-value:2.00E-18 ID:SGTC_2959|Compound:9079155|FD-Score:3.88|P-value:5.47E-5 ID:SGTC_3190|Compound:9110366|FD-Score:-3.66|P-value:1.29E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-4.78|P-value:9.28E-7 ID:SGTC_3263|Compound:9137018|FD-Score:-3.24|P-value:6.04E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.79|P-value:8.04E-5

Top fitness defect scores for YOR170W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_457 grayanotoxin iii 6.33 135.0 µM 1.36E-10 18 1.21E-10
2 SGTC_2881 9058953 5.43 52.0 µM 3.13E-8 5 2.87E-8
3 SGTC_1656 st012921 4.76 11.0 µM 1.04E-6 20 9.75E-7
4 SGTC_2022 5136654 4.07 200.0 µM 2.51E-5 19 2.38E-5
5 SGTC_1937 st074714 3.97 47.2 µM 3.75E-5 40 3.56E-5
6 SGTC_2959 9079155 3.88 11.0 µM 5.47E-5 29 5.21E-5
7 SGTC_2657 nystatin 3.83 74.4 µM 6.69E-5 13 6.38E-5
8 SGTC_3352 9151559 3.79 45.6 µM 8.04E-5 15 7.67E-5
9 SGTC_2434 5670830 3.77 169.9 µM 8.71E-5 32 8.32E-5
10 SGTC_1865 st057639 3.68 52.2 µM 1.23E-4 19 1.18E-4
11 SGTC_1069 diphenylcyclopropenone 3.66 8.5 µM 1.33E-4 40 1.27E-4
12 SGTC_2727 riluzole 3.64 51.8 µM 1.45E-4 mitochondrial processes 17 1.38E-4
13 SGTC_1960 st011366 3.61 51.8 µM 1.58E-4 18 1.51E-4
14 SGTC_1092 toremifene 3.58 6.3 µM 1.83E-4 31 1.75E-4
15 SGTC_513 4245-1575 3.57 41.7 µM 1.87E-4 unfolded protein response 135 1.79E-4
16 SGTC_98 0074-0023 3.56 107.7 µM 1.95E-4 Golgi 55 1.87E-4
17 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 3.47 49.5 µM 2.73E-4 35 2.62E-4
18 SGTC_2714 st079313 3.22 56.9 µM 6.69E-4 24 6.45E-4
19 SGTC_867 0518-0118 3.21 155.0 µM 6.96E-4 DNA intercalators 49 6.72E-4
20 SGTC_378 3970-0959 3.20 8.3 µM 7.21E-4 38 6.96E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.184 5.25E-27 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.134 7.13E-15 YHR082C KSP1 hom Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress
0.132 2.06E-14 YCR047C BUD23 hom Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern
0.128 9.38E-14 YPL056C_p LCL1_p hom Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan
0.127 1.58E-13 YOR171C LCB4 hom Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes
0.121 1.81E-12 YML009C-A_d YML009C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.116 1.63E-11 YJL134W LCB3 hom Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
0.116 1.81E-11 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.114 3.04E-11 YDR297W SUR2 hom Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
0.113 5.92E-11 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.099 1.02E-8 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.096 2.49E-8 YLR052W IES3 hom Subunit of the INO80 chromatin remodeling complex
0.096 2.83E-8 YDL033C SLM3 hom tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
0.096 2.88E-8 YDR115W YDR115W hom Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress
0.093 7.34E-8 YDR223W CRF1 hom Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain