YOR184W / SER1

3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR184W / SER1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:4.21|P-value:2.19E-5 ID:SGTC_37|Compound:0566-0070|FD-Score:3.45|P-value:4.12E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:4.81|P-value:1.50E-6 ID:SGTC_195|Compound:4234-0266|FD-Score:6.59|P-value:7.53E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:3.31|P-value:6.64E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:4.15|P-value:2.74E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:6.27|P-value:5.43E-10 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.39|P-value:5.04E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:6.24|P-value:6.77E-10 ID:SGTC_513|Compound:4245-1575|FD-Score:6.52|P-value:1.17E-10 ID:SGTC_572|Compound:0960-0087|FD-Score:3.48|P-value:3.71E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:3.95|P-value:6.34E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.57|P-value:2.49E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.55|P-value:2.83E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.75|P-value:1.95E-6 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.32|P-value:6.36E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.63|P-value:2.15E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.41|P-value:4.72E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.20|P-value:9.55E-4 ID:SGTC_1615|Compound:st002656|FD-Score:3.53|P-value:3.09E-4 ID:SGTC_1620|Compound:st003704|FD-Score:-3.65|P-value:1.84E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-4.41|P-value:8.81E-6 ID:SGTC_1666|Compound:st014829|FD-Score:3.57|P-value:2.65E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:13.00|P-value:5.50E-37 ID:SGTC_1908|Compound:st060353|FD-Score:7.02|P-value:4.55E-12 ID:SGTC_1910|Compound:st062352|FD-Score:4.17|P-value:2.60E-5 ID:SGTC_2008|Compound:4012253|FD-Score:4.10|P-value:3.38E-5 ID:SGTC_2083|Compound:5306046|FD-Score:4.49|P-value:6.54E-6 ID:SGTC_2143|Compound:5623677|FD-Score:-3.24|P-value:7.93E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-3.60|P-value:2.26E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.71|P-value:1.57E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.24|P-value:8.35E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:6.05|P-value:2.13E-9 ID:SGTC_2267|Compound:7931562|FD-Score:3.83|P-value:1.02E-4 ID:SGTC_2332|Compound:7982454|FD-Score:4.85|P-value:1.23E-6 ID:SGTC_2339|Compound:9000433|FD-Score:-3.57|P-value:2.53E-4 ID:SGTC_2432|Compound:5630864|FD-Score:4.76|P-value:1.93E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:9.49|P-value:1.42E-20 ID:SGTC_2961|Compound:9083290|FD-Score:3.62|P-value:2.17E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.63|P-value:2.12E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.25|P-value:8.06E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.44|P-value:4.24E-4 ID:SGTC_3077|Compound:9117319|FD-Score:3.55|P-value:2.86E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.80|P-value:1.12E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:4.21|P-value:2.19E-5 ID:SGTC_37|Compound:0566-0070|FD-Score:3.45|P-value:4.12E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:4.81|P-value:1.50E-6 ID:SGTC_195|Compound:4234-0266|FD-Score:6.59|P-value:7.53E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:3.31|P-value:6.64E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:4.15|P-value:2.74E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:6.27|P-value:5.43E-10 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.39|P-value:5.04E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:6.24|P-value:6.77E-10 ID:SGTC_513|Compound:4245-1575|FD-Score:6.52|P-value:1.17E-10 ID:SGTC_572|Compound:0960-0087|FD-Score:3.48|P-value:3.71E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:3.95|P-value:6.34E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.57|P-value:2.49E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.55|P-value:2.83E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.75|P-value:1.95E-6 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.32|P-value:6.36E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.63|P-value:2.15E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.41|P-value:4.72E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.20|P-value:9.55E-4 ID:SGTC_1615|Compound:st002656|FD-Score:3.53|P-value:3.09E-4 ID:SGTC_1620|Compound:st003704|FD-Score:-3.65|P-value:1.84E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-4.41|P-value:8.81E-6 ID:SGTC_1666|Compound:st014829|FD-Score:3.57|P-value:2.65E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:13.00|P-value:5.50E-37 ID:SGTC_1908|Compound:st060353|FD-Score:7.02|P-value:4.55E-12 ID:SGTC_1910|Compound:st062352|FD-Score:4.17|P-value:2.60E-5 ID:SGTC_2008|Compound:4012253|FD-Score:4.10|P-value:3.38E-5 ID:SGTC_2083|Compound:5306046|FD-Score:4.49|P-value:6.54E-6 ID:SGTC_2143|Compound:5623677|FD-Score:-3.24|P-value:7.93E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-3.60|P-value:2.26E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.71|P-value:1.57E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.24|P-value:8.35E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:6.05|P-value:2.13E-9 ID:SGTC_2267|Compound:7931562|FD-Score:3.83|P-value:1.02E-4 ID:SGTC_2332|Compound:7982454|FD-Score:4.85|P-value:1.23E-6 ID:SGTC_2339|Compound:9000433|FD-Score:-3.57|P-value:2.53E-4 ID:SGTC_2432|Compound:5630864|FD-Score:4.76|P-value:1.93E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:9.49|P-value:1.42E-20 ID:SGTC_2961|Compound:9083290|FD-Score:3.62|P-value:2.17E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.63|P-value:2.12E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.25|P-value:8.06E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.44|P-value:4.24E-4 ID:SGTC_3077|Compound:9117319|FD-Score:3.55|P-value:2.86E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.80|P-value:1.12E-4

Top fitness defect scores for YOR184W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1844 rapamycin 13.00 4.0 nM 5.50E-37 17 5.15E-39
2 SGTC_2679 rapamycin 9.49 1.0 nM 1.42E-20 31 1.15E-21
3 SGTC_1908 st060353 7.02 56.5 µM 4.55E-12 RPP1 & pyrimidine depletion 5 1.12E-12
4 SGTC_195 4234-0266 6.59 16.6 µM 7.53E-11 6 2.17E-11
5 SGTC_513 4245-1575 6.52 41.7 µM 1.17E-10 unfolded protein response 39 3.45E-11
6 SGTC_386 1509-0011 6.27 3.1 µM 5.43E-10 87 1.75E-10
7 SGTC_428 3448-4153 6.24 16.5 µM 6.77E-10 TSC3-RPN4 8 2.21E-10
8 SGTC_2233 sulbentine 6.05 40.4 µM 2.13E-9 23 7.45E-10
9 SGTC_2332 7982454 4.85 138.9 µM 1.23E-6 29 6.12E-7
10 SGTC_50 0929-0078 4.81 56.4 µM 1.50E-6 33 7.55E-7
11 SGTC_2432 5630864 4.76 12.2 µM 1.93E-6 12 9.88E-7
12 SGTC_1242 0402-0103 4.75 60.1 µM 1.95E-6 16 1.00E-6
13 SGTC_2083 5306046 4.49 65.9 µM 6.54E-6 13 3.59E-6
14 SGTC_7 0192-1582 4.21 4.2 µM 2.19E-5 50 1.28E-5
15 SGTC_1910 st062352 4.17 60.4 µM 2.60E-5 27 1.54E-5
16 SGTC_371 0195-0006 4.15 7.4 µM 2.74E-5 16 1.63E-5
17 SGTC_2008 4012253 4.10 172.0 µM 3.38E-5 22 2.03E-5
18 SGTC_697 0508-1955 3.95 564.0 µM 6.34E-5 33 3.95E-5
19 SGTC_2267 7931562 3.83 200.0 µM 1.02E-4 23 6.50E-5
20 SGTC_3320 9137005 3.80 35.1 µM 1.12E-4 endomembrane recycling 18 7.20E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.369 8.51E-109 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.364 3.17E-105 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.363 1.75E-104 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
0.357 1.29E-100 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.322 9.11E-82 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.305 6.81E-73 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.296 1.06E-68 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.289 2.02E-65 YJR139C HOM6 hom Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
0.285 7.85E-64 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.283 7.71E-63 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.280 2.19E-61 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.265 6.25E-55 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.261 2.96E-53 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.255 8.17E-51 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.248 3.34E-48 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD