HIPHOP chemogenomics database

YOR189W / IES4

Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses

Zygosity: Homozygous strain

fixedexpanded
Profile for YOR189W / IES4

Click on Significant Values for Screen Details

Top fitness defect scores for YOR189W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2582	agaric acid	7.07	100.0 µM	5.33E-12	redox potentiating	126	7.58E-13
2	SGTC_2112	5488546	5.00	200.0 µM	7.54E-7	TSC3-RPN4	8	2.93E-7
3	SGTC_88	0180-0332	4.40	8.7 µM	1.10E-5		14	5.33E-6
4	SGTC_1022	4477-0945	4.21	21.3 µM	2.45E-5		17	1.27E-5
5	SGTC_1923	st058458	4.19	19.1 µM	2.69E-5		27	1.40E-5
6	SGTC_2860	9025725	4.12	39.0 µM	3.52E-5	RPP1 & pyrimidine depletion	7	1.87E-5
7	SGTC_3081	9117243	4.00	49.5 µM	5.67E-5	fatty acid desaturase (OLE1)	18	3.13E-5
8	SGTC_2431	5490079	3.99	200.0 µM	5.89E-5		33	3.26E-5
9	SGTC_968	1309-0633	3.91	340.0 µM	8.25E-5		13	4.70E-5
10	SGTC_200	k038-0079	3.84	37.5 µM	1.06E-4	ubiquinone biosynthesis & proteasome	59	6.12E-5
11	SGTC_1510	1123-0200	3.84	71.5 µM	1.06E-4		47	6.15E-5
12	SGTC_1511	0906-3109	3.75	28.5 µM	1.46E-4	excess fatty acid	57	8.67E-5
13	SGTC_2805	7950783	3.71	58.4 µM	1.74E-4		39	1.05E-4
14	SGTC_2907	7721985	3.68	69.9 µM	1.91E-4		30	1.16E-4
15	SGTC_961	1252-1571	3.65	372.0 µM	2.15E-4		39	1.32E-4
16	SGTC_1705	st027868	3.63	56.3 µM	2.31E-4		15	1.43E-4
17	SGTC_2628	lathosterol	3.63	100.0 µM	2.33E-4		39	1.44E-4
18	SGTC_2167	5876490	3.61	200.0 µM	2.44E-4		42	1.51E-4
19	SGTC_1908	st060353	3.57	56.5 µM	2.82E-4	RPP1 & pyrimidine depletion	55	1.77E-4
20	SGTC_2475	5812728	3.56	15.0 µM	2.92E-4	mitochondrial processes	32	1.84E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.244	8.65E-47	YNL106C	INP52	hom	Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.196	1.90E-30	YNL027W	CRZ1	hom	Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.175	1.30E-24	YML103C	NUP188	hom	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.171	2.08E-23	YNL105W_d	RRT16_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.166	3.61E-22	YOR049C	RSB1	hom	Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.166	4.63E-22	YEL007W	MIT1	hom	Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.160	1.20E-20	YML052W	SUR7	hom	Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.158	3.72E-20	YPL232W	SSO1	hom	Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.155	1.53E-19	YLR238W	FAR10	hom	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
0.153	4.49E-19	YIL018W	RPL2B	hom	Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures
0.149	3.34E-18	YMR109W	MYO5	hom	One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.143	1.12E-16	YNL215W	IES2	hom	Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.140	4.32E-16	YLR206W	ENT2	hom	Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.139	6.48E-16	YIL129C	TAO3	het	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.138	1.11E-15	YHR001W-A	QCR10	hom	Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain