YOR191W / ULS1

Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR191W / ULS1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:4.46|P-value:3.03E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.20|P-value:7.15E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.20|P-value:5.75E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:18.40|P-value:1.45E-77 ID:SGTC_93|Compound:0109-0045|FD-Score:5.83|P-value:1.77E-9 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.88|P-value:5.34E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.49|P-value:1.94E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.65|P-value:1.35E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:4.32|P-value:5.86E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:4.04|P-value:2.05E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.46|P-value:2.15E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:3.66|P-value:1.00E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:6.63|P-value:9.47E-12 ID:SGTC_343|Compound:4130-2827|FD-Score:3.56|P-value:1.50E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.18|P-value:6.11E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.16|P-value:6.50E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.73|P-value:8.00E-7 ID:SGTC_600|Compound:1495-0418|FD-Score:4.65|P-value:1.18E-6 ID:SGTC_605|Compound:1315-0399|FD-Score:3.37|P-value:3.06E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.24|P-value:4.85E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.11|P-value:7.63E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:4.32|P-value:5.73E-6 ID:SGTC_707|Compound:0865-0008|FD-Score:4.04|P-value:2.02E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:3.04|P-value:9.90E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:23.50|P-value:4.83E-124 ID:SGTC_899|Compound:1083-0020|FD-Score:3.23|P-value:5.09E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.48|P-value:2.04E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:4.11|P-value:1.48E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:6.74|P-value:4.37E-12 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.15|P-value:6.68E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:5.00|P-value:1.97E-7 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.04|P-value:2.04E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:5.51|P-value:1.17E-8 ID:SGTC_1048|Compound:3161-0300|FD-Score:5.14|P-value:9.38E-8 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.14|P-value:1.32E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:-4.31|P-value:8.11E-6 ID:SGTC_1079|Compound:idarubicin|FD-Score:7.20|P-value:1.62E-13 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.95|P-value:3.08E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.04|P-value:9.83E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.67|P-value:9.59E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.47|P-value:2.09E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-3.31|P-value:4.83E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-4.07|P-value:2.34E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.93|P-value:3.24E-5 ID:SGTC_1707|Compound:st032323|FD-Score:10.40|P-value:4.78E-26 ID:SGTC_1784|Compound:st039334|FD-Score:-4.21|P-value:1.29E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-3.55|P-value:1.95E-4 ID:SGTC_1859|Compound:st055998|FD-Score:9.85|P-value:1.26E-23 ID:SGTC_1915|Compound:st067105|FD-Score:4.35|P-value:4.95E-6 ID:SGTC_1930|Compound:st074634|FD-Score:9.07|P-value:2.30E-20 ID:SGTC_1931|Compound:st074438|FD-Score:3.06|P-value:9.29E-4 ID:SGTC_1958|Compound:st076513|FD-Score:4.30|P-value:6.50E-6 ID:SGTC_2023|Compound:5144124|FD-Score:-3.71|P-value:1.07E-4 ID:SGTC_2048|Compound:5246248|FD-Score:4.82|P-value:5.08E-7 ID:SGTC_2109|Compound:5483026|FD-Score:3.31|P-value:3.80E-4 ID:SGTC_2128|Compound:5255449|FD-Score:10.70|P-value:1.25E-27 ID:SGTC_2152|Compound:5568786|FD-Score:3.68|P-value:9.19E-5 ID:SGTC_2201|Compound:6605497|FD-Score:3.06|P-value:9.14E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.09|P-value:8.23E-4 ID:SGTC_2229|Compound:7354935|FD-Score:3.46|P-value:2.21E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.21|P-value:5.53E-4 ID:SGTC_2262|Compound:9014885|FD-Score:3.65|P-value:1.02E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-3.87|P-value:5.54E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:5.41|P-value:2.05E-8 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-5.16|P-value:1.19E-7 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.15|P-value:1.26E-5 ID:SGTC_2671|Compound:danthron|FD-Score:4.25|P-value:7.99E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.13|P-value:7.12E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.66|P-value:9.86E-5 ID:SGTC_2887|Compound:9044784|FD-Score:5.38|P-value:2.45E-8 ID:SGTC_2916|Compound:7875993|FD-Score:4.72|P-value:8.57E-7 ID:SGTC_2928|Compound:9011484|FD-Score:4.87|P-value:3.95E-7 ID:SGTC_2972|Compound:9093619|FD-Score:3.33|P-value:3.48E-4 ID:SGTC_3160|Compound:9100216|FD-Score:-4.06|P-value:2.45E-5 ID:SGTC_3173|Compound:9105693|FD-Score:-3.46|P-value:2.78E-4 ID:SGTC_3247|Compound:9135149|FD-Score:16.80|P-value:1.25E-64 ID:SGTC_3254|Compound:9136651|FD-Score:3.65|P-value:1.06E-4 ID:SGTC_3344|Compound:9148862|FD-Score:5.19|P-value:7.06E-8 ID:SGTC_9|Compound:0092-0002|FD-Score:4.46|P-value:3.03E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.20|P-value:7.15E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.20|P-value:5.75E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:18.40|P-value:1.45E-77 ID:SGTC_93|Compound:0109-0045|FD-Score:5.83|P-value:1.77E-9 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.88|P-value:5.34E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.49|P-value:1.94E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.65|P-value:1.35E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:4.32|P-value:5.86E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:4.04|P-value:2.05E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.46|P-value:2.15E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:3.66|P-value:1.00E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:6.63|P-value:9.47E-12 ID:SGTC_343|Compound:4130-2827|FD-Score:3.56|P-value:1.50E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.18|P-value:6.11E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.16|P-value:6.50E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.73|P-value:8.00E-7 ID:SGTC_600|Compound:1495-0418|FD-Score:4.65|P-value:1.18E-6 ID:SGTC_605|Compound:1315-0399|FD-Score:3.37|P-value:3.06E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.24|P-value:4.85E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.11|P-value:7.63E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:4.32|P-value:5.73E-6 ID:SGTC_707|Compound:0865-0008|FD-Score:4.04|P-value:2.02E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:3.04|P-value:9.90E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:23.50|P-value:4.83E-124 ID:SGTC_899|Compound:1083-0020|FD-Score:3.23|P-value:5.09E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.48|P-value:2.04E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:4.11|P-value:1.48E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:6.74|P-value:4.37E-12 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.15|P-value:6.68E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:5.00|P-value:1.97E-7 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.04|P-value:2.04E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:5.51|P-value:1.17E-8 ID:SGTC_1048|Compound:3161-0300|FD-Score:5.14|P-value:9.38E-8 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.14|P-value:1.32E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:-4.31|P-value:8.11E-6 ID:SGTC_1079|Compound:idarubicin|FD-Score:7.20|P-value:1.62E-13 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.95|P-value:3.08E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.04|P-value:9.83E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.67|P-value:9.59E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.47|P-value:2.09E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-3.31|P-value:4.83E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-4.07|P-value:2.34E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.93|P-value:3.24E-5 ID:SGTC_1707|Compound:st032323|FD-Score:10.40|P-value:4.78E-26 ID:SGTC_1784|Compound:st039334|FD-Score:-4.21|P-value:1.29E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-3.55|P-value:1.95E-4 ID:SGTC_1859|Compound:st055998|FD-Score:9.85|P-value:1.26E-23 ID:SGTC_1915|Compound:st067105|FD-Score:4.35|P-value:4.95E-6 ID:SGTC_1930|Compound:st074634|FD-Score:9.07|P-value:2.30E-20 ID:SGTC_1931|Compound:st074438|FD-Score:3.06|P-value:9.29E-4 ID:SGTC_1958|Compound:st076513|FD-Score:4.30|P-value:6.50E-6 ID:SGTC_2023|Compound:5144124|FD-Score:-3.71|P-value:1.07E-4 ID:SGTC_2048|Compound:5246248|FD-Score:4.82|P-value:5.08E-7 ID:SGTC_2109|Compound:5483026|FD-Score:3.31|P-value:3.80E-4 ID:SGTC_2128|Compound:5255449|FD-Score:10.70|P-value:1.25E-27 ID:SGTC_2152|Compound:5568786|FD-Score:3.68|P-value:9.19E-5 ID:SGTC_2201|Compound:6605497|FD-Score:3.06|P-value:9.14E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.09|P-value:8.23E-4 ID:SGTC_2229|Compound:7354935|FD-Score:3.46|P-value:2.21E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.21|P-value:5.53E-4 ID:SGTC_2262|Compound:9014885|FD-Score:3.65|P-value:1.02E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-3.87|P-value:5.54E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:5.41|P-value:2.05E-8 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-5.16|P-value:1.19E-7 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.15|P-value:1.26E-5 ID:SGTC_2671|Compound:danthron|FD-Score:4.25|P-value:7.99E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.13|P-value:7.12E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.66|P-value:9.86E-5 ID:SGTC_2887|Compound:9044784|FD-Score:5.38|P-value:2.45E-8 ID:SGTC_2916|Compound:7875993|FD-Score:4.72|P-value:8.57E-7 ID:SGTC_2928|Compound:9011484|FD-Score:4.87|P-value:3.95E-7 ID:SGTC_2972|Compound:9093619|FD-Score:3.33|P-value:3.48E-4 ID:SGTC_3160|Compound:9100216|FD-Score:-4.06|P-value:2.45E-5 ID:SGTC_3173|Compound:9105693|FD-Score:-3.46|P-value:2.78E-4 ID:SGTC_3247|Compound:9135149|FD-Score:16.80|P-value:1.25E-64 ID:SGTC_3254|Compound:9136651|FD-Score:3.65|P-value:1.06E-4 ID:SGTC_3344|Compound:9148862|FD-Score:5.19|P-value:7.06E-8

Top fitness defect scores for YOR191W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_829 1635-0120 23.50 117.0 µM 4.83E-124 DNA damage response 1 5.97E-122
2 SGTC_73 0327-0325 18.40 16.2 µM 1.45E-77 DNA damage response 1 3.26E-76
3 SGTC_3247 9135149 16.80 49.5 µM 1.25E-64 DNA damage response 1 1.73E-63
4 SGTC_2128 5255449 10.70 168.5 µM 1.25E-27 1 4.17E-27
5 SGTC_1707 st032323 10.40 6.3 µM 4.78E-26 DNA damage response 9 1.50E-25
6 SGTC_1859 st055998 9.85 20.0 µM 1.26E-23 1 3.60E-23
7 SGTC_1930 st074634 9.07 34.3 µM 2.30E-20 RNA pol III & RNase P/MRP 4 5.74E-20
8 SGTC_1079 idarubicin 7.20 2.4 µM 1.62E-13 DNA damage response 4 3.04E-13
9 SGTC_997 3996-0078 6.74 137.0 µM 4.37E-12 1 7.72E-12
10 SGTC_238 5hr heat shock (37°C) + nsc-638432 6.63 8.9 µM 9.47E-12 heat shock/prefoldin 13 1.65E-11
11 SGTC_93 0109-0045 5.83 59.2 µM 1.77E-9 DNA damage response 13 2.78E-9
12 SGTC_1047 2043-3044 5.51 82.0 µM 1.17E-8 11 1.77E-8
13 SGTC_2532 xanthone 5.41 78.9 µM 2.05E-8 13 3.08E-8
14 SGTC_2887 9044784 5.38 58.4 µM 2.45E-8 fatty acid desaturase (OLE1) 9 3.66E-8
15 SGTC_3344 9148862 5.19 3.9 µM 7.06E-8 3 1.03E-7
16 SGTC_1048 3161-0300 5.14 24.5 µM 9.38E-8 7 1.37E-7
17 SGTC_1004 4084-0029 5.00 199.0 µM 1.97E-7 6 2.82E-7
18 SGTC_2928 9011484 4.87 9.8 µM 3.95E-7 heme biosynthesis & mitochondrial translocase 19 5.60E-7
19 SGTC_2048 5246248 4.82 200.0 µM 5.08E-7 2 7.16E-7
20 SGTC_580 1123-0028 4.73 41.0 µM 8.00E-7 DNA damage response 14 1.12E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.420 1.47E-143 YDR004W RAD57 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
0.415 4.47E-140 YDR076W RAD55 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
0.356 1.35E-100 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.329 1.21E-85 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.326 7.90E-84 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.307 5.52E-74 YOL006C TOP1 hom Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
0.247 7.55E-48 YER095W RAD51 hom Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
0.237 3.49E-44 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.236 1.48E-43 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.222 1.09E-38 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.217 3.62E-37 YDR075W PPH3 hom Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes
0.202 3.75E-32 YBR154C RPB5 het RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
0.189 2.40E-28 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.170 2.78E-23 YMR048W CSM3 hom Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress
0.170 4.27E-23 YBR202W MCM7 het Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex