YOR194C / TOA1

TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR194C / TOA1

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:-3.48|P-value:1.94E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.80|P-value:5.20E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:7.95|P-value:2.42E-16 ID:SGTC_197|Compound:4544-0043|FD-Score:3.84|P-value:4.38E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:3.04|P-value:9.31E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.20|P-value:5.35E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.40|P-value:2.65E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.23|P-value:4.82E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.62|P-value:1.06E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.61|P-value:1.15E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.85|P-value:4.16E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.72|P-value:7.31E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.90|P-value:3.36E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:4.43|P-value:2.99E-6 ID:SGTC_692|Compound:k241-0027|FD-Score:3.11|P-value:7.39E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.12|P-value:7.22E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.16|P-value:6.22E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:3.14|P-value:6.70E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:6.02|P-value:3.85E-10 ID:SGTC_903|Compound:1134-0042|FD-Score:3.33|P-value:3.28E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.04|P-value:9.46E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.64|P-value:1.01E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.37|P-value:2.91E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:5.77|P-value:1.92E-9 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.45|P-value:2.09E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:-3.26|P-value:4.52E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.21|P-value:5.15E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.25|P-value:4.41E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:5.34|P-value:2.50E-8 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.14|P-value:6.66E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.12|P-value:7.04E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.52|P-value:1.96E-6 ID:SGTC_1754|Compound:st042065|FD-Score:3.96|P-value:2.66E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.78|P-value:5.64E-5 ID:SGTC_1818|Compound:st052136|FD-Score:5.34|P-value:2.44E-8 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.38|P-value:2.75E-4 ID:SGTC_1959|Compound:st077091|FD-Score:7.98|P-value:1.79E-16 ID:SGTC_2036|Compound:5160441|FD-Score:4.96|P-value:2.03E-7 ID:SGTC_2053|Compound:5265679|FD-Score:-3.33|P-value:3.43E-4 ID:SGTC_2073|Compound:5212005|FD-Score:3.36|P-value:2.99E-4 ID:SGTC_2147|Compound:5545932|FD-Score:4.32|P-value:5.20E-6 ID:SGTC_2436|Compound:5633522|FD-Score:3.83|P-value:4.63E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.41|P-value:2.46E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.88|P-value:3.66E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:3.31|P-value:3.63E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.33|P-value:3.41E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.82|P-value:4.98E-5 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.15|P-value:6.49E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.26|P-value:4.39E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:4.50|P-value:2.14E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.22|P-value:5.08E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.28|P-value:4.02E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.15|P-value:6.51E-4 ID:SGTC_2818|Compound:7996756|FD-Score:3.33|P-value:3.34E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-5.13|P-value:8.41E-8 ID:SGTC_3142|Compound:9086498|FD-Score:-3.03|P-value:9.91E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.14|P-value:1.74E-10 ID:SGTC_3212|Compound:9128307|FD-Score:5.54|P-value:7.71E-9 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.48|P-value:1.94E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.80|P-value:5.20E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:7.95|P-value:2.42E-16 ID:SGTC_197|Compound:4544-0043|FD-Score:3.84|P-value:4.38E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:3.04|P-value:9.31E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.20|P-value:5.35E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.40|P-value:2.65E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.23|P-value:4.82E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.62|P-value:1.06E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.61|P-value:1.15E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.85|P-value:4.16E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.72|P-value:7.31E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.90|P-value:3.36E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:4.43|P-value:2.99E-6 ID:SGTC_692|Compound:k241-0027|FD-Score:3.11|P-value:7.39E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.12|P-value:7.22E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.16|P-value:6.22E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:3.14|P-value:6.70E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:6.02|P-value:3.85E-10 ID:SGTC_903|Compound:1134-0042|FD-Score:3.33|P-value:3.28E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.04|P-value:9.46E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.64|P-value:1.01E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.37|P-value:2.91E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:5.77|P-value:1.92E-9 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.45|P-value:2.09E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:-3.26|P-value:4.52E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.21|P-value:5.15E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.25|P-value:4.41E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:5.34|P-value:2.50E-8 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.14|P-value:6.66E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.12|P-value:7.04E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.52|P-value:1.96E-6 ID:SGTC_1754|Compound:st042065|FD-Score:3.96|P-value:2.66E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.78|P-value:5.64E-5 ID:SGTC_1818|Compound:st052136|FD-Score:5.34|P-value:2.44E-8 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.38|P-value:2.75E-4 ID:SGTC_1959|Compound:st077091|FD-Score:7.98|P-value:1.79E-16 ID:SGTC_2036|Compound:5160441|FD-Score:4.96|P-value:2.03E-7 ID:SGTC_2053|Compound:5265679|FD-Score:-3.33|P-value:3.43E-4 ID:SGTC_2073|Compound:5212005|FD-Score:3.36|P-value:2.99E-4 ID:SGTC_2147|Compound:5545932|FD-Score:4.32|P-value:5.20E-6 ID:SGTC_2436|Compound:5633522|FD-Score:3.83|P-value:4.63E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.41|P-value:2.46E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.88|P-value:3.66E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:3.31|P-value:3.63E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.33|P-value:3.41E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.82|P-value:4.98E-5 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.15|P-value:6.49E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.26|P-value:4.39E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:4.50|P-value:2.14E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.22|P-value:5.08E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.28|P-value:4.02E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.15|P-value:6.51E-4 ID:SGTC_2818|Compound:7996756|FD-Score:3.33|P-value:3.34E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-5.13|P-value:8.41E-8 ID:SGTC_3142|Compound:9086498|FD-Score:-3.03|P-value:9.91E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.14|P-value:1.74E-10 ID:SGTC_3212|Compound:9128307|FD-Score:5.54|P-value:7.71E-9

Top fitness defect scores for YOR194C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1959 st077091 7.98 55.8 µM 1.79E-16 RPP1 & pyrimidine depletion 6 7.18E-16 0.86
2 SGTC_178 4092-0806 7.95 87.5 µM 2.42E-16 ergosterol depletion effects on membrane 6 9.59E-16 1.12
3 SGTC_3152 9099253 6.14 49.5 µM 1.74E-10 NEO1-PIK1 12 4.01E-10 0.17
4 SGTC_902 1120-0002 6.02 2.1 µM 3.85E-10 azole & statin 6 8.61E-10 0.15
5 SGTC_1003 4049-0218 5.77 100.0 µM 1.92E-9 1 4.03E-9 0.51
6 SGTC_3212 9128307 5.54 49.5 µM 7.71E-9 4 1.53E-8 0.68
7 SGTC_1818 st052136 5.34 56.3 µM 2.44E-8 NEO1-PIK1 7 4.63E-8 0.08
8 SGTC_1310 1188-0297 5.34 994.0 nM 2.50E-8 azole & statin 8 4.73E-8 0.38
9 SGTC_2036 5160441 4.96 105.0 µM 2.03E-7 NEO1 18 3.54E-7 0.06
10 SGTC_1712 st032288 4.52 53.4 µM 1.96E-6 calcium & mitochondrial duress 29 3.12E-6 0.05
11 SGTC_2735 sertaconazole 4.50 140.0 nM 2.14E-6 plasma membrane duress 2 3.40E-6 0.72
12 SGTC_601 0986-0029 4.43 62.9 µM 2.99E-6 calcium & mitochondrial duress 13 4.69E-6 0.06
13 SGTC_2147 5545932 4.32 89.7 µM 5.20E-6 ergosterol biosynthesis 10 7.97E-6 0.10
14 SGTC_1754 st042065 3.96 16.1 µM 2.66E-5 NEO1-PIK1 33 3.82E-5 0.02
15 SGTC_550 4123-0385 3.90 25.7 µM 3.36E-5 TSC3-RPN4 9 4.80E-5 0.03
16 SGTC_2541 muurolladie-3-one 3.88 83.1 µM 3.66E-5 excess fatty acid 19 5.20E-5 0.09
17 SGTC_457 grayanotoxin iii 3.85 135.0 µM 4.16E-5 21 5.89E-5 0.02
18 SGTC_197 4544-0043 3.84 41.6 µM 4.38E-5 endomembrane recycling 25 6.18E-5 0.18
19 SGTC_2436 5633522 3.83 8.1 µM 4.63E-5 14 6.52E-5 0.06
20 SGTC_168 3970-0862 3.80 530.5 µM 5.20E-5 48 7.29E-5 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.218 1.77E-37 YMR043W MCM1 het Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes
0.200 1.10E-31 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.197 9.45E-31 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.194 8.77E-30 YDL167C NRP1 hom Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis
0.193 2.15E-29 YGL043W DST1 hom General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress
0.189 2.08E-28 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.177 4.06E-25 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.169 7.16E-23 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.167 2.88E-22 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.159 1.75E-20 YGL016W KAP122 hom Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance
0.159 2.41E-20 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.158 4.28E-20 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.156 1.07E-19 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.156 1.22E-19 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.155 1.38E-19 YBL103C RTG3 hom Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways