YOR201C / MRM1

Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR201C / MRM1

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:3.46|P-value:5.00E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.15|P-value:3.98E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:3.65|P-value:2.63E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.40|P-value:1.49E-7 ID:SGTC_195|Compound:4234-0266|FD-Score:3.48|P-value:4.60E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:7.41|P-value:1.08E-12 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.94|P-value:9.05E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.45|P-value:6.02E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.99|P-value:1.10E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:4.71|P-value:3.94E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:3.82|P-value:1.39E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.89|P-value:1.09E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.55|P-value:8.92E-8 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.45|P-value:5.93E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.90|P-value:1.05E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.36|P-value:6.84E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.28|P-value:9.08E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:5.00|P-value:1.01E-6 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.74|P-value:1.86E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.11|P-value:4.63E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.61|P-value:2.98E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.95|P-value:1.29E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.57|P-value:3.97E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.62|P-value:5.69E-6 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.70|P-value:2.13E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.72|P-value:2.03E-4 ID:SGTC_1627|Compound:st003713|FD-Score:9.05|P-value:4.91E-18 ID:SGTC_1640|Compound:st009078|FD-Score:3.50|P-value:4.38E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.72|P-value:2.02E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.62|P-value:7.02E-6 ID:SGTC_1742|Compound:st038235|FD-Score:8.82|P-value:3.12E-17 ID:SGTC_1767|Compound:st044992|FD-Score:-3.67|P-value:2.89E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.27|P-value:3.01E-5 ID:SGTC_1860|Compound:st056228|FD-Score:3.36|P-value:6.88E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.89|P-value:1.08E-4 ID:SGTC_1922|Compound:5578187|FD-Score:7.35|P-value:1.59E-12 ID:SGTC_1962|Compound:st076595|FD-Score:-3.66|P-value:2.90E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.26|P-value:9.52E-4 ID:SGTC_2191|Compound:5911152|FD-Score:6.48|P-value:4.06E-10 ID:SGTC_2233|Compound:sulbentine|FD-Score:5.44|P-value:1.24E-7 ID:SGTC_2290|Compound:7904846|FD-Score:8.15|P-value:5.82E-15 ID:SGTC_2321|Compound:7390090|FD-Score:4.05|P-value:5.82E-5 ID:SGTC_2331|Compound:7980721|FD-Score:3.65|P-value:2.58E-4 ID:SGTC_2337|Compound:9009472|FD-Score:4.21|P-value:3.15E-5 ID:SGTC_2459|Compound:5811157|FD-Score:3.38|P-value:6.56E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.75|P-value:1.79E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.50|P-value:5.09E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.36|P-value:6.99E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.45|P-value:5.12E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.39|P-value:1.51E-5 ID:SGTC_2705|Compound:st078069|FD-Score:3.42|P-value:5.75E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:-3.55|P-value:4.36E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.03|P-value:7.68E-5 ID:SGTC_2836|Compound:9010338|FD-Score:-3.36|P-value:8.00E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.49|P-value:5.21E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.34|P-value:7.39E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.64|P-value:2.67E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.30|P-value:8.44E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.67|P-value:2.43E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.83|P-value:1.33E-4 ID:SGTC_3341|Compound:9147222|FD-Score:4.46|P-value:1.12E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:3.46|P-value:5.00E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.15|P-value:3.98E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:3.65|P-value:2.63E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.40|P-value:1.49E-7 ID:SGTC_195|Compound:4234-0266|FD-Score:3.48|P-value:4.60E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:7.41|P-value:1.08E-12 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.94|P-value:9.05E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.45|P-value:6.02E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.99|P-value:1.10E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:4.71|P-value:3.94E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:3.82|P-value:1.39E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.89|P-value:1.09E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.55|P-value:8.92E-8 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.45|P-value:5.93E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.90|P-value:1.05E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.36|P-value:6.84E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.28|P-value:9.08E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:5.00|P-value:1.01E-6 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.74|P-value:1.86E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.11|P-value:4.63E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.61|P-value:2.98E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.95|P-value:1.29E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.57|P-value:3.97E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.62|P-value:5.69E-6 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.70|P-value:2.13E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.72|P-value:2.03E-4 ID:SGTC_1627|Compound:st003713|FD-Score:9.05|P-value:4.91E-18 ID:SGTC_1640|Compound:st009078|FD-Score:3.50|P-value:4.38E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.72|P-value:2.02E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.62|P-value:7.02E-6 ID:SGTC_1742|Compound:st038235|FD-Score:8.82|P-value:3.12E-17 ID:SGTC_1767|Compound:st044992|FD-Score:-3.67|P-value:2.89E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.27|P-value:3.01E-5 ID:SGTC_1860|Compound:st056228|FD-Score:3.36|P-value:6.88E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.89|P-value:1.08E-4 ID:SGTC_1922|Compound:5578187|FD-Score:7.35|P-value:1.59E-12 ID:SGTC_1962|Compound:st076595|FD-Score:-3.66|P-value:2.90E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.26|P-value:9.52E-4 ID:SGTC_2191|Compound:5911152|FD-Score:6.48|P-value:4.06E-10 ID:SGTC_2233|Compound:sulbentine|FD-Score:5.44|P-value:1.24E-7 ID:SGTC_2290|Compound:7904846|FD-Score:8.15|P-value:5.82E-15 ID:SGTC_2321|Compound:7390090|FD-Score:4.05|P-value:5.82E-5 ID:SGTC_2331|Compound:7980721|FD-Score:3.65|P-value:2.58E-4 ID:SGTC_2337|Compound:9009472|FD-Score:4.21|P-value:3.15E-5 ID:SGTC_2459|Compound:5811157|FD-Score:3.38|P-value:6.56E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.75|P-value:1.79E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.50|P-value:5.09E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.36|P-value:6.99E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.45|P-value:5.12E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.39|P-value:1.51E-5 ID:SGTC_2705|Compound:st078069|FD-Score:3.42|P-value:5.75E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:-3.55|P-value:4.36E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.03|P-value:7.68E-5 ID:SGTC_2836|Compound:9010338|FD-Score:-3.36|P-value:8.00E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.49|P-value:5.21E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.34|P-value:7.39E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.64|P-value:2.67E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.30|P-value:8.44E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.67|P-value:2.43E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.83|P-value:1.33E-4 ID:SGTC_3341|Compound:9147222|FD-Score:4.46|P-value:1.12E-5

Top fitness defect scores for YOR201C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1627 st003713 9.05 25.6 µM 4.91E-18 calcium & mitochondrial duress 9 7.02E-20
2 SGTC_1742 st038235 8.82 28.9 µM 3.12E-17 mitochondrial stress 18 5.52E-19
3 SGTC_2290 7904846 8.15 200.0 µM 5.82E-15 1 1.88E-16
4 SGTC_236 1509-0011 7.41 5.3 µM 1.08E-12 260 6.31E-14
5 SGTC_1922 5578187 7.35 25.0 µM 1.59E-12 TRP & mitochondrial translation 2 9.73E-14
6 SGTC_2191 5911152 6.48 200.0 µM 4.06E-10 1 4.68E-11
7 SGTC_2233 sulbentine 5.44 40.4 µM 1.24E-7 29 2.73E-8
8 SGTC_173 1273-0061 5.40 2.7 µM 1.49E-7 mitochondrial stress 130 3.34E-8
9 SGTC_979 1426-2828 5.00 121.0 µM 1.01E-6 7 2.80E-7
10 SGTC_275 trichlorophene 4.99 5.7 µM 1.10E-6 mitochondrial stress 167 3.08E-7
11 SGTC_1188 1403-0014 4.95 4.6 µM 1.29E-6 mitochondrial stress 28 3.67E-7
12 SGTC_310 1273-0058 4.71 1.1 µM 3.94E-6 mitochondrial stress 195 1.27E-6
13 SGTC_1350 1495-0454 4.62 146.0 µM 5.69E-6 10 1.91E-6
14 SGTC_3341 9147222 4.46 25.9 µM 1.12E-5 RNA processing & uracil transport 6 4.06E-6
15 SGTC_2617 dihydrotanshinone i 4.39 20.8 µM 1.51E-5 copper-dependent oxidative stress 25 5.65E-6
16 SGTC_2337 9009472 4.21 200.0 µM 3.15E-5 25 1.27E-5
17 SGTC_28 pentachloropyridine N-oxide 4.15 1.6 µM 3.98E-5 TSC3-RPN4 62 1.65E-5
18 SGTC_1128 3448-9350 4.11 235.0 µM 4.63E-5 22 1.95E-5
19 SGTC_2321 7390090 4.05 138.8 µM 5.82E-5 22 2.51E-5
20 SGTC_261 5-fluorouridine 3.94 15.4 µM 9.05E-5 exosome 11 4.10E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.360 3.85E-103 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.340 1.08E-91 YHR168W MTG2 hom Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.331 1.15E-86 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.326 4.02E-84 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.326 4.55E-84 YLR091W GEP5 hom Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine
0.324 4.78E-83 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.315 4.08E-78 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.312 1.34E-76 YGR150C CCM1 hom Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport
0.310 1.20E-75 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.310 1.63E-75 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.306 1.38E-73 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.303 2.82E-72 YDL056W MBP1 hom Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
0.301 6.71E-71 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.298 7.32E-70 YBL038W MRPL16 hom Mitochondrial ribosomal protein of the large subunit
0.294 4.34E-68 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit