YOR215C / AIM41

Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR215C / AIM41

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.66|P-value:5.31E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.16|P-value:3.58E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:2.94|P-value:9.43E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.08|P-value:7.75E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:2.96|P-value:8.64E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.15|P-value:4.34E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:2.95|P-value:8.98E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-2.91|P-value:9.12E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.63|P-value:6.03E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:-3.83|P-value:2.11E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:-3.50|P-value:8.93E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:3.60|P-value:6.82E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:2.93|P-value:9.71E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.03|P-value:6.87E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.14|P-value:4.53E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.19|P-value:3.26E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-5.09|P-value:2.81E-8 ID:SGTC_1743|Compound:st037606|FD-Score:3.77|P-value:3.24E-5 ID:SGTC_1746|Compound:st038117|FD-Score:-2.97|P-value:7.31E-4 ID:SGTC_1866|Compound:st057638|FD-Score:-3.36|P-value:1.61E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.60|P-value:6.90E-5 ID:SGTC_1905|Compound:st060207|FD-Score:3.46|P-value:1.27E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.08|P-value:5.65E-4 ID:SGTC_2534|Compound:helenine|FD-Score:2.99|P-value:7.70E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:5.91|P-value:1.79E-10 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.16|P-value:4.15E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.88|P-value:1.72E-5 ID:SGTC_2954|Compound:9074818|FD-Score:-3.18|P-value:3.40E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.14|P-value:4.45E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.05|P-value:5.58E-4 ID:SGTC_3143|Compound:9086658|FD-Score:2.93|P-value:9.68E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.74|P-value:3.22E-5 ID:SGTC_3182|Compound:9108849|FD-Score:3.22|P-value:3.26E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.66|P-value:5.31E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.16|P-value:3.58E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:2.94|P-value:9.43E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.08|P-value:7.75E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:2.96|P-value:8.64E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.15|P-value:4.34E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:2.95|P-value:8.98E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-2.91|P-value:9.12E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.63|P-value:6.03E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:-3.83|P-value:2.11E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:-3.50|P-value:8.93E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:3.60|P-value:6.82E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:2.93|P-value:9.71E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.03|P-value:6.87E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.14|P-value:4.53E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.19|P-value:3.26E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-5.09|P-value:2.81E-8 ID:SGTC_1743|Compound:st037606|FD-Score:3.77|P-value:3.24E-5 ID:SGTC_1746|Compound:st038117|FD-Score:-2.97|P-value:7.31E-4 ID:SGTC_1866|Compound:st057638|FD-Score:-3.36|P-value:1.61E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.60|P-value:6.90E-5 ID:SGTC_1905|Compound:st060207|FD-Score:3.46|P-value:1.27E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.08|P-value:5.65E-4 ID:SGTC_2534|Compound:helenine|FD-Score:2.99|P-value:7.70E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:5.91|P-value:1.79E-10 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.16|P-value:4.15E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.88|P-value:1.72E-5 ID:SGTC_2954|Compound:9074818|FD-Score:-3.18|P-value:3.40E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.14|P-value:4.45E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.05|P-value:5.58E-4 ID:SGTC_3143|Compound:9086658|FD-Score:2.93|P-value:9.68E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.74|P-value:3.22E-5 ID:SGTC_3182|Compound:9108849|FD-Score:3.22|P-value:3.26E-4

Top fitness defect scores for YOR215C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2560 caryophyllene 5.91 100.0 µM 1.79E-10 3 1.69E-9
2 SGTC_310 1273-0058 4.08 1.1 µM 7.75E-6 mitochondrial stress 234 2.26E-5
3 SGTC_1743 st037606 3.77 46.4 µM 3.24E-5 25 8.09E-5
4 SGTC_6 0844-0013 3.66 19.8 µM 5.31E-5 120 1.26E-4
5 SGTC_562 3772-2733 3.63 112.0 µM 6.03E-5 ERG2 93 1.41E-4
6 SGTC_936 3005-4620 3.60 401.0 µM 6.82E-5 34 1.57E-4
7 SGTC_1880 MG-132 3.60 525.0 µM 6.90E-5 26 1.59E-4
8 SGTC_1905 st060207 3.46 84.5 µM 1.27E-4 19 2.74E-4
9 SGTC_3182 9108849 3.22 49.5 µM 3.26E-4 RPP1 & pyrimidine depletion 31 6.37E-4
10 SGTC_2750 bromebric acid 3.16 70.2 µM 4.15E-4 75 7.90E-4
11 SGTC_342 k048-0088 3.15 23.3 µM 4.34E-4 RSC & ERG11 44 8.23E-4
12 SGTC_2956 9076196 3.14 2.5 µM 4.45E-4 61 8.42E-4
13 SGTC_1144 3486-0183 3.14 12.5 µM 4.53E-4 54 8.55E-4
14 SGTC_1906 st060206 3.08 94.7 µM 5.65E-4 58 0.00104
15 SGTC_1108 betulinic acid 3.03 729.1 nM 6.87E-4 46 0.00124
16 SGTC_2534 helenine 2.99 20.1 µM 7.70E-4 RSC complex & mRNA processing 40 0.00138
17 SGTC_315 k915-0449 2.96 187.0 µM 8.64E-4 115 0.00152
18 SGTC_353 1988-1175 2.95 58.3 µM 8.98E-4 unfolded protein response 70 0.00158
19 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 2.94 44.4 nM 9.43E-4 DNA damage response 73 0.00165
20 SGTC_3143 9086658 2.93 49.5 µM 9.68E-4 110 0.00169

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 5.72E-17 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.135 3.71E-15 YDR244W PEX5 hom Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions
0.132 1.47E-14 YJR108W ABM1 hom Protein of unknown function, required for normal microtubule organization
0.132 1.52E-14 YLR412W BER1 hom Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene
0.123 7.86E-13 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.121 2.22E-12 YDL030W PRP9 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex
0.116 1.44E-11 YPL004C LSP1 hom Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family
0.115 2.13E-11 YER028C MIG3 hom Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication
0.115 2.90E-11 YDR179C CSN9 hom Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
0.114 4.16E-11 YDR014W RAD61 hom Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin
0.111 9.74E-11 YLR311C_d YLR311C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.111 1.02E-10 YLL014W EMC6 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93
0.108 2.89E-10 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.108 2.89E-10 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.108 3.23E-10 YGL138C_p YGL138C_p hom Putative protein of unknown function; has no significant sequence similarity to any known protein