YOR219C / STE13

Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR219C / STE13

Click on Significant Values for Screen Details ID:SGTC_253|Compound:dyclonine|FD-Score:3.30|P-value:5.13E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.71|P-value:1.09E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.00|P-value:3.32E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.12|P-value:9.70E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.20|P-value:7.44E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-4.46|P-value:3.16E-6 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.17|P-value:8.16E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.20|P-value:7.32E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.35|P-value:4.40E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.50|P-value:1.93E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.22|P-value:6.90E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.79|P-value:7.94E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.51|P-value:2.43E-4 ID:SGTC_2317|Compound:5986382|FD-Score:3.53|P-value:2.19E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.07|P-value:9.05E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.39|P-value:3.72E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.16|P-value:6.61E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:4.36|P-value:6.86E-6 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.53|P-value:2.22E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.53|P-value:1.68E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.75|P-value:7.13E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.38|P-value:3.02E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.39|P-value:2.95E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.35|P-value:4.35E-4 ID:SGTC_2911|Compound:7942208|FD-Score:3.14|P-value:9.11E-4 ID:SGTC_3115|Compound:9123671|FD-Score:3.68|P-value:1.27E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.59|P-value:1.79E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.30|P-value:5.13E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.71|P-value:1.09E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.00|P-value:3.32E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.12|P-value:9.70E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.20|P-value:7.44E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-4.46|P-value:3.16E-6 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.17|P-value:8.16E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.20|P-value:7.32E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.35|P-value:4.40E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.50|P-value:1.93E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.22|P-value:6.90E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.79|P-value:7.94E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.51|P-value:2.43E-4 ID:SGTC_2317|Compound:5986382|FD-Score:3.53|P-value:2.19E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.07|P-value:9.05E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.39|P-value:3.72E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.16|P-value:6.61E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:4.36|P-value:6.86E-6 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.53|P-value:2.22E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.53|P-value:1.68E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.75|P-value:7.13E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.38|P-value:3.02E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.39|P-value:2.95E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.35|P-value:4.35E-4 ID:SGTC_2911|Compound:7942208|FD-Score:3.14|P-value:9.11E-4 ID:SGTC_3115|Compound:9123671|FD-Score:3.68|P-value:1.27E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.59|P-value:1.79E-4

Top fitness defect scores for YOR219C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2557 derrustone 4.36 83.8 µM 6.86E-6 23 6.42E-6
2 SGTC_390 dec-rvkr-cmk 4.00 16.7 µM 3.32E-5 calcium & mitochondrial duress 24 3.11E-5
3 SGTC_1905 st060207 3.79 84.5 µM 7.94E-5 16 7.42E-5
4 SGTC_313 3474-0040 3.71 5.0 µM 1.09E-4 NEO1-PIK1 82 1.02E-4
5 SGTC_3115 9123671 3.68 49.5 µM 1.27E-4 5 1.19E-4
6 SGTC_3143 9086658 3.59 49.5 µM 1.79E-4 64 1.67E-4
7 SGTC_2317 5986382 3.53 200.0 µM 2.19E-4 23 2.05E-4
8 SGTC_2558 carylophyllene oxide 3.53 100.0 µM 2.22E-4 24 2.07E-4
9 SGTC_1928 4'-methoxychalcone 3.51 40.3 µM 2.43E-4 20 2.27E-4
10 SGTC_2364 9055074 3.39 200.0 µM 3.72E-4 34 3.48E-4
11 SGTC_2822 7994718 3.35 71.4 µM 4.35E-4 33 4.06E-4
12 SGTC_1214 0358-0031 3.35 63.7 µM 4.40E-4 33 4.11E-4
13 SGTC_253 dyclonine 3.30 31.2 µM 5.13E-4 amide catabolism 57 4.79E-4
14 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 3.22 54.9 µM 6.90E-4 redox potentiating 78 6.44E-4
15 SGTC_1072 oxiconazole 3.20 14.9 nM 7.32E-4 ergosterol depletion effects on membrane 79 6.83E-4
16 SGTC_611 3453-1652 3.20 23.7 µM 7.44E-4 56 6.95E-4
17 SGTC_1028 k015-0029 3.17 4.8 µM 8.16E-4 55 7.62E-4
18 SGTC_2911 7942208 3.14 15.6 µM 9.11E-4 mitochondrial response to ROS 34 8.51E-4
19 SGTC_551 k048-0028 3.12 34.9 µM 9.70E-4 52 9.06E-4
20 SGTC_1269 0831-0796 3.09 3.0 µM 0.00108 60S ribosome export 41 0.00101

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 2.56E-14 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.118 6.05E-12 YGR189C CRH1 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress
0.117 1.11E-11 YDR215C_d YDR215C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
0.099 7.84E-9 YGR100W MDR1 hom Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function
0.099 7.99E-9 YOL099C_d YOL099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes
0.098 1.43E-8 YJR153W PGU1 hom Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
0.091 1.36E-7 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.090 1.57E-7 YDL238C GUD1 hom Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures
0.090 1.67E-7 YPL185W_d YPL185W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
0.090 1.71E-7 YDR497C ITR1 hom Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress
0.087 3.99E-7 YLR128W DCN1 hom Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation
0.087 4.83E-7 YDL146W LDB17 hom Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck
0.086 5.60E-7 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.085 8.79E-7 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.085 9.47E-7 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol