YOR222W / ODC2

Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR222W / ODC2

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:2.85|P-value:9.42E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:5.68|P-value:2.95E-10 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.05|P-value:4.37E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:2.96|P-value:6.11E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:4.28|P-value:1.54E-6 ID:SGTC_320|Compound:4092-0846|FD-Score:3.20|P-value:2.41E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.39|P-value:8.47E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.27|P-value:1.78E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.18|P-value:2.61E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:4.08|P-value:4.19E-6 ID:SGTC_619|Compound:1652-1634|FD-Score:3.32|P-value:1.48E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-4.37|P-value:9.60E-7 ID:SGTC_710|Compound:3448-4187|FD-Score:3.33|P-value:1.38E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:2.88|P-value:8.29E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:-2.97|P-value:6.04E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.37|P-value:1.17E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-6.17|P-value:8.38E-12 ID:SGTC_990|Compound:3985-0011|FD-Score:3.90|P-value:1.05E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.35|P-value:1.30E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:-4.73|P-value:1.27E-7 ID:SGTC_1091|Compound:telmisartan|FD-Score:-2.90|P-value:7.75E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.70|P-value:2.74E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:-2.87|P-value:8.76E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.41|P-value:1.00E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:2.96|P-value:6.31E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:-2.88|P-value:8.55E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:2.98|P-value:5.78E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.23|P-value:2.10E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.45|P-value:8.49E-5 ID:SGTC_1701|Compound:st028638|FD-Score:2.84|P-value:9.64E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-2.87|P-value:8.77E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.09|P-value:3.83E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-4.07|P-value:4.53E-6 ID:SGTC_1813|Compound:st051246|FD-Score:2.92|P-value:7.21E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-2.97|P-value:6.07E-4 ID:SGTC_1987|Compound:st072290|FD-Score:4.14|P-value:3.14E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:2.88|P-value:8.35E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.11|P-value:3.49E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.87|P-value:1.21E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:5.05|P-value:1.79E-8 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-4.40|P-value:8.17E-7 ID:SGTC_2681|Compound:menadione|FD-Score:2.95|P-value:6.39E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.54|P-value:5.62E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-2.91|P-value:7.52E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.08|P-value:3.98E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-4.34|P-value:1.10E-6 ID:SGTC_2938|Compound:9059746|FD-Score:3.60|P-value:4.40E-5 ID:SGTC_2966|Compound:9084041|FD-Score:2.85|P-value:9.32E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-2.86|P-value:8.96E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.19|P-value:2.50E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.08|P-value:3.86E-4 ID:SGTC_3240|Compound:9133527|FD-Score:3.23|P-value:2.11E-4 ID:SGTC_3336|Compound:9143619|FD-Score:4.18|P-value:2.53E-6 ID:SGTC_3348|Compound:9149464|FD-Score:-4.47|P-value:5.57E-7 ID:SGTC_2|Compound:0422-0095|FD-Score:2.85|P-value:9.42E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:5.68|P-value:2.95E-10 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.05|P-value:4.37E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:2.96|P-value:6.11E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:4.28|P-value:1.54E-6 ID:SGTC_320|Compound:4092-0846|FD-Score:3.20|P-value:2.41E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.39|P-value:8.47E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.27|P-value:1.78E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.18|P-value:2.61E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:4.08|P-value:4.19E-6 ID:SGTC_619|Compound:1652-1634|FD-Score:3.32|P-value:1.48E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-4.37|P-value:9.60E-7 ID:SGTC_710|Compound:3448-4187|FD-Score:3.33|P-value:1.38E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:2.88|P-value:8.29E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:-2.97|P-value:6.04E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.37|P-value:1.17E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-6.17|P-value:8.38E-12 ID:SGTC_990|Compound:3985-0011|FD-Score:3.90|P-value:1.05E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.35|P-value:1.30E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:-4.73|P-value:1.27E-7 ID:SGTC_1091|Compound:telmisartan|FD-Score:-2.90|P-value:7.75E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.70|P-value:2.74E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:-2.87|P-value:8.76E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.41|P-value:1.00E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:2.96|P-value:6.31E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:-2.88|P-value:8.55E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:2.98|P-value:5.78E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.23|P-value:2.10E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.45|P-value:8.49E-5 ID:SGTC_1701|Compound:st028638|FD-Score:2.84|P-value:9.64E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-2.87|P-value:8.77E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.09|P-value:3.83E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-4.07|P-value:4.53E-6 ID:SGTC_1813|Compound:st051246|FD-Score:2.92|P-value:7.21E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-2.97|P-value:6.07E-4 ID:SGTC_1987|Compound:st072290|FD-Score:4.14|P-value:3.14E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:2.88|P-value:8.35E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.11|P-value:3.49E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.87|P-value:1.21E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:5.05|P-value:1.79E-8 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-4.40|P-value:8.17E-7 ID:SGTC_2681|Compound:menadione|FD-Score:2.95|P-value:6.39E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.54|P-value:5.62E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-2.91|P-value:7.52E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.08|P-value:3.98E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-4.34|P-value:1.10E-6 ID:SGTC_2938|Compound:9059746|FD-Score:3.60|P-value:4.40E-5 ID:SGTC_2966|Compound:9084041|FD-Score:2.85|P-value:9.32E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-2.86|P-value:8.96E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.19|P-value:2.50E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.08|P-value:3.86E-4 ID:SGTC_3240|Compound:9133527|FD-Score:3.23|P-value:2.11E-4 ID:SGTC_3336|Compound:9143619|FD-Score:4.18|P-value:2.53E-6 ID:SGTC_3348|Compound:9149464|FD-Score:-4.47|P-value:5.57E-7

Top fitness defect scores for YOR222W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_66 0109-0187 5.68 42.4 µM 2.95E-10 13 6.81E-9
2 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 5.05 100.0 µM 1.79E-8 12 2.19E-7
3 SGTC_533 1222-0222 4.39 6.7 µM 8.47E-7 PDR1 20 5.70E-6
4 SGTC_182 3448-4371 4.28 550.5 µM 1.54E-6 19 9.44E-6
5 SGTC_3336 9143619 4.18 71.4 µM 2.53E-6 16 1.44E-5
6 SGTC_1987 st072290 4.14 61.9 µM 3.14E-6 12 1.73E-5
7 SGTC_603 3794-0023 4.08 45.9 µM 4.19E-6 10 2.21E-5
8 SGTC_990 3985-0011 3.90 41.3 µM 1.05E-5 amide catabolism 22 4.81E-5
9 SGTC_2595 hexamethylquercetagetin 3.87 100.0 µM 1.21E-5 27 5.42E-5
10 SGTC_1115 galangin 3.70 695.7 nM 2.74E-5 RPP1 & pyrimidine depletion 23 1.08E-4
11 SGTC_2938 9059746 3.60 27.3 µM 4.40E-5 fatty acid desaturase (OLE1) 50 1.62E-4
12 SGTC_2702 st077768 3.54 96.8 µM 5.62E-5 22 1.99E-4
13 SGTC_1627 st003713 3.45 25.6 µM 8.49E-5 calcium & mitochondrial duress 107 2.83E-4
14 SGTC_1231 0242-0792 3.41 125.0 µM 1.00E-4 34 3.26E-4
15 SGTC_801 0866-0028 3.37 10.1 µM 1.17E-4 56 3.71E-4
16 SGTC_710 3448-4187 3.33 58.0 µM 1.38E-4 fatty acid desaturase (OLE1) 93 4.28E-4
17 SGTC_619 1652-1634 3.32 108.0 µM 1.48E-4 PDR1 40 4.54E-4
18 SGTC_1394 3474-0001 3.23 65.7 µM 2.10E-4 endomembrane recycling 66 6.10E-4
19 SGTC_3240 9133527 3.23 49.5 µM 2.11E-4 29 6.14E-4
20 SGTC_320 4092-0846 3.20 5.3 µM 2.41E-4 ergosterol depletion effects on membrane 81 6.87E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 8.89E-12 YPR088C SRP54 het Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
0.104 1.85E-9 YOL129W VPS68 hom Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria
0.103 2.18E-9 YDR132C YDR132C hom Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication
0.100 7.72E-9 YER101C AST2 hom Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication
0.096 2.79E-8 YAR007C RFA1 het Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
0.095 3.89E-8 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.092 8.55E-8 YPL038W-A_p YPL038W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.088 3.51E-7 YDR033W MRH1 hom Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication
0.087 5.33E-7 YPR072W NOT5 hom Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
0.086 6.41E-7 YAL068C PAU8 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
0.085 8.05E-7 YMR269W TMA23 hom Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan
0.084 9.95E-7 YER104W RTT105 het Protein with a role in regulation of Ty1 transposition
0.084 1.08E-6 YDL159W-A_p YDL159W-A_p hom Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
0.083 1.41E-6 YKL120W OAC1 hom Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family
0.080 3.14E-6 YGL038C OCH1 hom Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins