YOR223W

Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR223W / YOR223W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.38|P-value:4.08E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.37|P-value:4.66E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:4.54|P-value:3.55E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:3.13|P-value:9.67E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.37|P-value:4.21E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.82|P-value:8.63E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.17|P-value:8.55E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:5.06|P-value:2.82E-7 ID:SGTC_908|Compound:3448-7491|FD-Score:4.88|P-value:6.80E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:3.57|P-value:2.05E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.42|P-value:6.20E-6 ID:SGTC_1100|Compound:amiodarone|FD-Score:4.01|P-value:3.60E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.44|P-value:3.27E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.81|P-value:8.91E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.37|P-value:7.67E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.02|P-value:3.88E-5 ID:SGTC_1547|Compound:harmine|FD-Score:-3.29|P-value:6.05E-4 ID:SGTC_1630|Compound:st005209|FD-Score:4.18|P-value:1.73E-5 ID:SGTC_1634|Compound:st006576|FD-Score:4.40|P-value:6.78E-6 ID:SGTC_1743|Compound:st037606|FD-Score:3.52|P-value:2.41E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.21|P-value:7.50E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.50|P-value:2.93E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.23|P-value:6.88E-4 ID:SGTC_2037|Compound:5169046|FD-Score:4.22|P-value:1.51E-5 ID:SGTC_2094|Compound:5332512|FD-Score:-3.74|P-value:1.19E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.87|P-value:6.34E-5 ID:SGTC_2307|Compound:7538926|FD-Score:-3.77|P-value:1.06E-4 ID:SGTC_2349|Compound:9023730|FD-Score:4.15|P-value:2.02E-5 ID:SGTC_2461|Compound:5755302|FD-Score:-3.20|P-value:8.17E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.17|P-value:8.47E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.31|P-value:5.17E-4 ID:SGTC_2716|Compound:st080858|FD-Score:4.94|P-value:5.02E-7 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.09|P-value:2.43E-7 ID:SGTC_2859|Compound:9028643|FD-Score:-3.22|P-value:7.66E-4 ID:SGTC_3004|Compound:9076122|FD-Score:-3.32|P-value:5.41E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.62|P-value:1.83E-4 ID:SGTC_3012|Compound:9080433|FD-Score:-6.04|P-value:1.35E-9 ID:SGTC_3016|Compound:9080866|FD-Score:5.08|P-value:2.56E-7 ID:SGTC_3017|Compound:9080681|FD-Score:-7.06|P-value:1.76E-12 ID:SGTC_3047|Compound:9092122|FD-Score:-4.06|P-value:3.27E-5 ID:SGTC_3058|Compound:9093861|FD-Score:-3.72|P-value:1.26E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-4.14|P-value:2.33E-5 ID:SGTC_3170|Compound:9103054|FD-Score:3.56|P-value:2.08E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.58|P-value:1.99E-4 ID:SGTC_3309|Compound:9129340|FD-Score:4.01|P-value:3.64E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.38|P-value:4.08E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.37|P-value:4.66E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:4.54|P-value:3.55E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:3.13|P-value:9.67E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.37|P-value:4.21E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.82|P-value:8.63E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.17|P-value:8.55E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:5.06|P-value:2.82E-7 ID:SGTC_908|Compound:3448-7491|FD-Score:4.88|P-value:6.80E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:3.57|P-value:2.05E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.42|P-value:6.20E-6 ID:SGTC_1100|Compound:amiodarone|FD-Score:4.01|P-value:3.60E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.44|P-value:3.27E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.81|P-value:8.91E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.37|P-value:7.67E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.02|P-value:3.88E-5 ID:SGTC_1547|Compound:harmine|FD-Score:-3.29|P-value:6.05E-4 ID:SGTC_1630|Compound:st005209|FD-Score:4.18|P-value:1.73E-5 ID:SGTC_1634|Compound:st006576|FD-Score:4.40|P-value:6.78E-6 ID:SGTC_1743|Compound:st037606|FD-Score:3.52|P-value:2.41E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.21|P-value:7.50E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.50|P-value:2.93E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.23|P-value:6.88E-4 ID:SGTC_2037|Compound:5169046|FD-Score:4.22|P-value:1.51E-5 ID:SGTC_2094|Compound:5332512|FD-Score:-3.74|P-value:1.19E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.87|P-value:6.34E-5 ID:SGTC_2307|Compound:7538926|FD-Score:-3.77|P-value:1.06E-4 ID:SGTC_2349|Compound:9023730|FD-Score:4.15|P-value:2.02E-5 ID:SGTC_2461|Compound:5755302|FD-Score:-3.20|P-value:8.17E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.17|P-value:8.47E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.31|P-value:5.17E-4 ID:SGTC_2716|Compound:st080858|FD-Score:4.94|P-value:5.02E-7 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.09|P-value:2.43E-7 ID:SGTC_2859|Compound:9028643|FD-Score:-3.22|P-value:7.66E-4 ID:SGTC_3004|Compound:9076122|FD-Score:-3.32|P-value:5.41E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.62|P-value:1.83E-4 ID:SGTC_3012|Compound:9080433|FD-Score:-6.04|P-value:1.35E-9 ID:SGTC_3016|Compound:9080866|FD-Score:5.08|P-value:2.56E-7 ID:SGTC_3017|Compound:9080681|FD-Score:-7.06|P-value:1.76E-12 ID:SGTC_3047|Compound:9092122|FD-Score:-4.06|P-value:3.27E-5 ID:SGTC_3058|Compound:9093861|FD-Score:-3.72|P-value:1.26E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-4.14|P-value:2.33E-5 ID:SGTC_3170|Compound:9103054|FD-Score:3.56|P-value:2.08E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.58|P-value:1.99E-4 ID:SGTC_3309|Compound:9129340|FD-Score:4.01|P-value:3.64E-5

Top fitness defect scores for YOR223W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2752 diclazuril 5.09 33.1 µM 2.43E-7 74 1.82E-7
2 SGTC_3016 9080866 5.08 49.5 µM 2.56E-7 9 1.92E-7
3 SGTC_814 3342-0569 5.06 96.0 µM 2.82E-7 9 2.12E-7
4 SGTC_2716 st080858 4.94 38.6 µM 5.02E-7 60S ribosome export 7 3.82E-7
5 SGTC_908 3448-7491 4.88 47.7 µM 6.80E-7 mitochondrial stress 81 5.21E-7
6 SGTC_303 1348-1668 4.54 34.2 µM 3.55E-6 2 2.83E-6
7 SGTC_1047 2043-3044 4.42 82.0 µM 6.20E-6 21 5.01E-6
8 SGTC_1634 st006576 4.40 41.0 µM 6.78E-6 TSC3-RPN4 13 5.49E-6
9 SGTC_1378 2093-0007 4.37 380.0 nM 7.67E-6 12 6.23E-6
10 SGTC_2037 5169046 4.22 200.0 µM 1.51E-5 60S ribosome export 11 1.24E-5
11 SGTC_1630 st005209 4.18 31.3 µM 1.73E-5 18 1.43E-5
12 SGTC_2349 9023730 4.15 187.1 µM 2.02E-5 20 1.68E-5
13 SGTC_1100 amiodarone 4.01 5.1 µM 3.60E-5 15 3.03E-5
14 SGTC_3309 9129340 4.01 25.8 µM 3.64E-5 12 3.06E-5
15 SGTC_2253 7938677 3.87 135.8 µM 6.34E-5 10 5.40E-5
16 SGTC_3207 9114163 3.58 49.5 µM 1.99E-4 42 1.74E-4
17 SGTC_961 1252-1571 3.57 372.0 µM 2.05E-4 43 1.79E-4
18 SGTC_3170 9103054 3.56 49.5 µM 2.08E-4 60S ribosome export 26 1.82E-4
19 SGTC_1743 st037606 3.52 46.4 µM 2.41E-4 34 2.12E-4
20 SGTC_1130 3454-2858 3.44 15.9 µM 3.27E-4 NEO1 113 2.89E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 4.49E-15 YOR252W TMA16 hom Protein of unknown function that associates with ribosomes
0.111 1.26E-10 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.105 1.19E-9 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.104 1.61E-9 YMR191W SPG5 hom Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.101 4.09E-9 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.099 1.06E-8 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.096 2.24E-8 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.095 3.63E-8 YLR311C_d YLR311C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.093 6.13E-8 YLR136C TIS11 hom mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.093 7.24E-8 YOR214C_p YOR214C_p hom Putative protein of unknown function; YOR214C is not an essential gene
0.092 8.91E-8 YLR128W DCN1 hom Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation
0.091 1.26E-7 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.090 1.83E-7 YLR297W YLR297W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication
0.088 3.41E-7 YKL149C DBR1 hom RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition
0.087 3.88E-7 YDR240C SNU56 het Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex