HIPHOP chemogenomics database
YOR223W 
Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOR223W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.135 | 4.49E-15 | YOR252W | TMA16 | hom | Protein of unknown function that associates with ribosomes |
| 0.111 | 1.26E-10 | YLL054C_p | YLL054C_p | hom | Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene |
| 0.105 | 1.19E-9 | YNL218W | MGS1 | hom | Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress |
| 0.104 | 1.61E-9 | YMR191W | SPG5 | hom | Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources |
| 0.101 | 4.09E-9 | YDR530C | APA2 | hom | Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication |
| 0.099 | 1.06E-8 | YMR107W | SPG4 | hom | Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources |
| 0.096 | 2.24E-8 | YHR021W-A_p | ECM12_p | hom | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity |
| 0.095 | 3.63E-8 | YLR311C_d | YLR311C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.093 | 6.13E-8 | YLR136C | TIS11 | hom | mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress |
| 0.093 | 7.24E-8 | YOR214C_p | YOR214C_p | hom | Putative protein of unknown function; YOR214C is not an essential gene |
| 0.092 | 8.91E-8 | YLR128W | DCN1 | hom | Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation |
| 0.091 | 1.26E-7 | YJR019C | TES1 | hom | Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids |
| 0.090 | 1.83E-7 | YLR297W | YLR297W | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication |
| 0.088 | 3.41E-7 | YKL149C | DBR1 | hom | RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition |
| 0.087 | 3.88E-7 | YDR240C | SNU56 | het | Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex |