YOR225W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR225W / YOR225W

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.24|P-value:5.87E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:-5.04|P-value:1.70E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:4.54|P-value:2.64E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:3.47|P-value:2.54E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.35|P-value:3.92E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.12|P-value:8.99E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.14|P-value:7.09E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-4.26|P-value:7.85E-6 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.43|P-value:2.55E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:4.62|P-value:1.75E-6 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.66|P-value:1.02E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.19|P-value:7.08E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:4.72|P-value:1.10E-6 ID:SGTC_953|Compound:1188-0045|FD-Score:3.48|P-value:2.40E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.14|P-value:8.43E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.11|P-value:9.32E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.06|P-value:9.44E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:4.45|P-value:4.08E-6 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.47|P-value:3.68E-6 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.92|P-value:4.18E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.46|P-value:2.25E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.68|P-value:9.52E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.24|P-value:5.77E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.49|P-value:2.36E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:5.41|P-value:2.74E-8 ID:SGTC_1519|Compound:esterone|FD-Score:-3.12|P-value:7.72E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.44|P-value:2.83E-4 ID:SGTC_1630|Compound:st005209|FD-Score:4.51|P-value:2.96E-6 ID:SGTC_1636|Compound:st007707|FD-Score:3.46|P-value:2.59E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.56|P-value:1.79E-4 ID:SGTC_1743|Compound:st037606|FD-Score:4.37|P-value:5.80E-6 ID:SGTC_1767|Compound:st044992|FD-Score:3.30|P-value:4.76E-4 ID:SGTC_1828|Compound:st055811|FD-Score:3.31|P-value:4.56E-4 ID:SGTC_1871|Compound:st057448|FD-Score:4.21|P-value:1.18E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:4.23|P-value:1.08E-5 ID:SGTC_1903|Compound:st060211|FD-Score:5.11|P-value:1.41E-7 ID:SGTC_1906|Compound:st060206|FD-Score:3.16|P-value:7.78E-4 ID:SGTC_2003|Compound:4023581|FD-Score:5.10|P-value:1.54E-7 ID:SGTC_2011|Compound:4012611|FD-Score:-3.14|P-value:7.14E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.10|P-value:1.98E-5 ID:SGTC_2082|Compound:5219693|FD-Score:-3.81|P-value:5.53E-5 ID:SGTC_2184|Compound:6075246|FD-Score:3.46|P-value:2.61E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-3.41|P-value:2.69E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.04|P-value:9.99E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.63|P-value:1.37E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.50|P-value:2.26E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.81|P-value:6.59E-5 ID:SGTC_2395|Compound:5646831|FD-Score:3.57|P-value:1.74E-4 ID:SGTC_2404|Compound:5161160|FD-Score:4.05|P-value:2.42E-5 ID:SGTC_2442|Compound:5158906|FD-Score:3.38|P-value:3.50E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.62|P-value:1.20E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.34|P-value:4.14E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.57|P-value:1.72E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.17|P-value:6.53E-4 ID:SGTC_2827|Compound:7993847|FD-Score:4.00|P-value:3.05E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.32|P-value:4.39E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.15|P-value:8.01E-4 ID:SGTC_3225|Compound:9130819|FD-Score:4.60|P-value:1.93E-6 ID:SGTC_3306|Compound:9127676|FD-Score:5.59|P-value:9.60E-9 ID:SGTC_3309|Compound:9129340|FD-Score:4.45|P-value:4.00E-6 ID:SGTC_3310|Compound:9130229|FD-Score:3.72|P-value:9.63E-5 ID:SGTC_3314|Compound:9135860|FD-Score:3.32|P-value:4.43E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:3.24|P-value:5.87E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:-5.04|P-value:1.70E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:4.54|P-value:2.64E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:3.47|P-value:2.54E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.35|P-value:3.92E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.12|P-value:8.99E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.14|P-value:7.09E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-4.26|P-value:7.85E-6 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.43|P-value:2.55E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:4.62|P-value:1.75E-6 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.66|P-value:1.02E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.19|P-value:7.08E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:4.72|P-value:1.10E-6 ID:SGTC_953|Compound:1188-0045|FD-Score:3.48|P-value:2.40E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.14|P-value:8.43E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.11|P-value:9.32E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.06|P-value:9.44E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:4.45|P-value:4.08E-6 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.47|P-value:3.68E-6 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.92|P-value:4.18E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.46|P-value:2.25E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.68|P-value:9.52E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.24|P-value:5.77E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.49|P-value:2.36E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:5.41|P-value:2.74E-8 ID:SGTC_1519|Compound:esterone|FD-Score:-3.12|P-value:7.72E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.44|P-value:2.83E-4 ID:SGTC_1630|Compound:st005209|FD-Score:4.51|P-value:2.96E-6 ID:SGTC_1636|Compound:st007707|FD-Score:3.46|P-value:2.59E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.56|P-value:1.79E-4 ID:SGTC_1743|Compound:st037606|FD-Score:4.37|P-value:5.80E-6 ID:SGTC_1767|Compound:st044992|FD-Score:3.30|P-value:4.76E-4 ID:SGTC_1828|Compound:st055811|FD-Score:3.31|P-value:4.56E-4 ID:SGTC_1871|Compound:st057448|FD-Score:4.21|P-value:1.18E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:4.23|P-value:1.08E-5 ID:SGTC_1903|Compound:st060211|FD-Score:5.11|P-value:1.41E-7 ID:SGTC_1906|Compound:st060206|FD-Score:3.16|P-value:7.78E-4 ID:SGTC_2003|Compound:4023581|FD-Score:5.10|P-value:1.54E-7 ID:SGTC_2011|Compound:4012611|FD-Score:-3.14|P-value:7.14E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.10|P-value:1.98E-5 ID:SGTC_2082|Compound:5219693|FD-Score:-3.81|P-value:5.53E-5 ID:SGTC_2184|Compound:6075246|FD-Score:3.46|P-value:2.61E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-3.41|P-value:2.69E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.04|P-value:9.99E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.63|P-value:1.37E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.50|P-value:2.26E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.81|P-value:6.59E-5 ID:SGTC_2395|Compound:5646831|FD-Score:3.57|P-value:1.74E-4 ID:SGTC_2404|Compound:5161160|FD-Score:4.05|P-value:2.42E-5 ID:SGTC_2442|Compound:5158906|FD-Score:3.38|P-value:3.50E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.62|P-value:1.20E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.34|P-value:4.14E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.57|P-value:1.72E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.17|P-value:6.53E-4 ID:SGTC_2827|Compound:7993847|FD-Score:4.00|P-value:3.05E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.32|P-value:4.39E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.15|P-value:8.01E-4 ID:SGTC_3225|Compound:9130819|FD-Score:4.60|P-value:1.93E-6 ID:SGTC_3306|Compound:9127676|FD-Score:5.59|P-value:9.60E-9 ID:SGTC_3309|Compound:9129340|FD-Score:4.45|P-value:4.00E-6 ID:SGTC_3310|Compound:9130229|FD-Score:3.72|P-value:9.63E-5 ID:SGTC_3314|Compound:9135860|FD-Score:3.32|P-value:4.43E-4

Top fitness defect scores for YOR225W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3306 9127676 5.59 59.8 µM 9.60E-9 4 1.11E-8
2 SGTC_1512 0259-0544 5.41 12.2 µM 2.74E-8 4 3.13E-8
3 SGTC_1903 st060211 5.11 78.3 µM 1.41E-7 6 1.58E-7
4 SGTC_2003 4023581 5.10 200.0 µM 1.54E-7 cell wall signaling 21 1.72E-7
5 SGTC_638 3970-0837 4.72 4.1 µM 1.10E-6 20 1.20E-6
6 SGTC_521 r062-0005 4.62 13.8 µM 1.75E-6 7 1.90E-6
7 SGTC_3225 9130819 4.60 49.5 µM 1.93E-6 amide catabolism 17 2.10E-6
8 SGTC_58 0957-0393 4.54 9.0 µM 2.64E-6 cell wall 324 2.86E-6
9 SGTC_1630 st005209 4.51 31.3 µM 2.96E-6 14 3.20E-6
10 SGTC_1424 4048-1941 4.47 275.0 µM 3.68E-6 13 3.97E-6
11 SGTC_3309 9129340 4.45 25.8 µM 4.00E-6 8 4.31E-6
12 SGTC_1376 2910-0861 4.45 41.3 µM 4.08E-6 11 4.39E-6
13 SGTC_1743 st037606 4.37 46.4 µM 5.80E-6 15 6.22E-6
14 SGTC_1876 myriocin 4.23 605.0 nM 1.08E-5 28 1.15E-5
15 SGTC_1871 st057448 4.21 67.3 µM 1.18E-5 19 1.26E-5
16 SGTC_2050 5263056 4.10 171.0 µM 1.98E-5 fatty acid desaturase (OLE1) 37 2.10E-5
17 SGTC_2404 5161160 4.05 200.0 µM 2.42E-5 17 2.56E-5
18 SGTC_2827 7993847 4.00 71.4 µM 3.05E-5 22 3.21E-5
19 SGTC_1431 4049-0260 3.92 9.1 µM 4.18E-5 4 4.39E-5
20 SGTC_2394 5221648 3.81 200.0 µM 6.59E-5 27 6.88E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.17E-16 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.134 5.55E-15 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.126 3.02E-13 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.122 1.19E-12 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
0.122 1.52E-12 YPL158C AIM44 hom Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.116 1.91E-11 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.112 7.32E-11 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.111 1.46E-10 YDR374C_p YDR374C_p hom Putative protein of unknown function
0.108 3.01E-10 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.108 3.49E-10 YML113W DAT1 hom DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability
0.107 5.57E-10 YMR106C YKU80 hom Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
0.105 1.10E-9 YPL092W SSU1 hom Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
0.104 1.27E-9 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.103 2.24E-9 YHR139C-A_d YHR139C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.102 3.01E-9 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family