HIPHOP chemogenomics database

YOR233W / KIN4

Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YOR233W / KIN4

Click on Significant Values for Screen Details

Top fitness defect scores for YOR233W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2058	5236698	12.60	133.0 µM	3.52E-39		3	1.46E-36
2	SGTC_2056	5235370	5.97	200.0 µM	2.53E-10		14	1.22E-9
3	SGTC_389	tpck	5.51	16.7 µM	4.57E-9		12	1.80E-8
4	SGTC_2781	5567276	5.23	71.4 µM	2.40E-8		21	8.43E-8
5	SGTC_3340	9146634	5.07	11.1 µM	6.10E-8		6	2.01E-7
6	SGTC_1839	st053978	4.75	48.0 µM	3.50E-7		8	1.02E-6
7	SGTC_2049	5262831	4.71	67.2 µM	4.38E-7		15	1.25E-6
8	SGTC_2566	crystal violet carbinol	4.61	226.0 nM	7.17E-7		24	1.98E-6
9	SGTC_3338	9144300	4.46	39.6 µM	1.58E-6	Golgi	21	4.14E-6
10	SGTC_751	0833-0568	4.16	350.0 µM	6.86E-6		15	1.62E-5
11	SGTC_2174	5790901	4.07	200.0 µM	1.02E-5	tubulin folding & SWR complex	34	2.34E-5
12	SGTC_771	0250-0039	4.02	27.3 µM	1.31E-5		11	2.96E-5
13	SGTC_341	1486-1430	3.80	230.0 µM	3.44E-5		27	7.24E-5
14	SGTC_2028	5153890	3.71	36.4 µM	5.14E-5	cell wall signaling	38	1.05E-4
15	SGTC_757	1066-0008	3.53	322.0 µM	1.08E-4	Golgi	31	2.10E-4
16	SGTC_245	methotrexate	3.49	289.6 µM	1.25E-4		54	2.40E-4
17	SGTC_2682	pyrogallin	3.46	40.0 µM	1.41E-4	copper-dependent oxidative stress	44	2.69E-4
18	SGTC_806	3966-4455	3.44	5.9 µM	1.52E-4		43	2.88E-4
19	SGTC_2399	5884133	3.38	200.0 µM	1.94E-4	cell wall signaling	103	3.62E-4
20	SGTC_2131	toluylene red	3.37	5.3 µM	2.04E-4	60S ribosome export	47	3.78E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.153	5.40E-19	YGR092W	DBF2	hom	Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis
0.140	4.63E-16	YOR247W	SRL1	hom	Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication
0.134	6.50E-15	YER068C-A_d	YER068C-A_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.117	1.34E-11	YOL073C	YOL073C	hom	Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2
0.116	1.96E-11	YIL140W	AXL2	hom	Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate
0.115	2.58E-11	YDL015C	TSC13	het	Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress
0.113	5.48E-11	YML026C	RPS18B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.113	5.90E-11	YDR393W	SHE9	hom	Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex
0.111	1.01E-10	YBR047W_p	FMP23_p	hom	Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.111	1.33E-10	YNL117W	MLS1	hom	Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic
0.101	4.79E-9	YJR133W	XPT1	hom	Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
0.097	1.83E-8	YPL191C_p	YPL191C_p	hom	Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.096	2.24E-8	YER042W	MXR1	hom	Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan
0.094	4.63E-8	YHR130C_d	YHR130C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.094	5.37E-8	YGR087C	PDC6	hom	Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation