HIPHOP chemogenomics database

YOR235W_d / IRC13

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci

Zygosity: Homozygous strain

fixedexpanded
Profile for YOR235W / IRC13

Click on Significant Values for Screen Details

Top fitness defect scores for YOR235W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2842	9000675	6.63	19.5 µM	6.97E-9		1	1.69E-11
2	SGTC_797	k781-0471	6.45	270.0 µM	1.67E-8	RPP1 & pyrimidine depletion	2	5.50E-11
3	SGTC_2688	kanamycin b	6.25	96.7 µM	4.33E-8	calcium & mitochondrial duress	140	1.99E-10
4	SGTC_118	0083-0097	6.23	135.3 µM	4.80E-8	translation	18	2.29E-10
5	SGTC_1914	st062367	6.18	72.6 µM	6.15E-8		3	3.19E-10
6	SGTC_3264	9137442	5.64	49.5 µM	7.10E-7		2	8.66E-9
7	SGTC_2962	9082311	5.60	13.2 µM	8.28E-7		5	1.07E-8
8	SGTC_1901	st060216	5.50	58.6 µM	1.26E-6		10	1.87E-8
9	SGTC_123	0083-0120	5.24	66.7 µM	3.73E-6		26	8.10E-8
10	SGTC_454	lyso-paf C-16	5.21	6.7 µM	4.26E-6		2	9.69E-8
11	SGTC_2739	tacrine	5.13	100.9 µM	5.80E-6	heme requiring	4	1.47E-7
12	SGTC_2839	9003951	5.04	26.0 µM	8.06E-6		5	2.29E-7
13	SGTC_2798	7813637	4.98	45.5 µM	1.03E-5		10	3.19E-7
14	SGTC_1723	st034307	4.86	2.5 µM	1.61E-5	mitochondrial processes	13	5.78E-7
15	SGTC_830	4076-0286	4.74	57.8 µM	2.55E-5	translation	36	1.08E-6
16	SGTC_2526	patulin	4.70	37.6 µM	2.98E-5		55	1.33E-6
17	SGTC_800	3448-7362	4.65	155.0 µM	3.49E-5	translation	107	1.64E-6
18	SGTC_701	4424-0219	4.65	185.0 µM	3.55E-5	calcium & mitochondrial duress	11	1.68E-6
19	SGTC_2325	6158266	4.60	200.0 µM	4.21E-5		14	2.12E-6
20	SGTC_2927	9011802	4.53	47.9 µM	5.39E-5		15	2.95E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.141	2.95E-16	YLR264W	RPS28B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication
0.133	9.90E-15	YDL061C	RPS29B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication
0.132	1.84E-14	YLR048W	RPS0B	hom	Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.121	1.91E-12	YDR140W	MTQ2	hom	S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.117	1.32E-11	YLR058C	SHM2	hom	Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis
0.116	2.08E-11	YGL246C	RAI1	hom	Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.114	4.35E-11	YLR264C-A_p	YLR264C-A_p	hom	Putative protein of unknown function
0.109	2.12E-10	YNL227C	JJJ1	hom	Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.109	2.69E-10	YLR061W	RPL22A	hom	Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.108	3.80E-10	YGR118W	RPS23A	hom	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.106	6.71E-10	YML031W	NDC1	het	Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
0.105	9.74E-10	YGR204W	ADE3	hom	Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.103	1.99E-9	YOR085W	OST3	hom	Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.103	2.61E-9	YER131W	RPS26B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication
0.102	3.40E-9	YJL189W	RPL39	hom	Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog