YOR238W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR238W / YOR238W

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:3.09|P-value:1.56E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.14|P-value:1.23E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:5.53|P-value:4.40E-11 ID:SGTC_297|Compound:0986-0032|FD-Score:2.66|P-value:9.82E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.19|P-value:9.84E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:2.91|P-value:3.45E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:4.46|P-value:8.51E-8 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.34|P-value:3.26E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:2.70|P-value:8.24E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:2.92|P-value:3.40E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-2.79|P-value:4.00E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-2.73|P-value:5.35E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:-2.82|P-value:3.54E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.20|P-value:9.24E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:3.31|P-value:5.46E-5 ID:SGTC_732|Compound:3970-1727|FD-Score:3.44|P-value:2.98E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.04|P-value:1.34E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:5.13|P-value:8.85E-10 ID:SGTC_806|Compound:3966-4455|FD-Score:2.77|P-value:6.31E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.07|P-value:1.17E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.26|P-value:4.83E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.08|P-value:1.97E-17 ID:SGTC_1124|Compound:fisetin|FD-Score:2.86|P-value:4.38E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:-2.76|P-value:4.70E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.29|P-value:4.02E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:2.88|P-value:3.97E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:3.22|P-value:8.64E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.21|P-value:5.94E-5 ID:SGTC_1986|Compound:st071812|FD-Score:-2.88|P-value:2.76E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.52|P-value:1.97E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.81|P-value:4.22E-6 ID:SGTC_2019|Compound:4016004|FD-Score:-2.63|P-value:8.04E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.37|P-value:4.20E-5 ID:SGTC_2164|Compound:5685496|FD-Score:4.01|P-value:1.38E-6 ID:SGTC_2217|Compound:6934799|FD-Score:2.67|P-value:9.47E-4 ID:SGTC_2348|Compound:9022543|FD-Score:4.34|P-value:1.89E-7 ID:SGTC_2352|Compound:9027995|FD-Score:-3.59|P-value:8.65E-6 ID:SGTC_2360|Compound:9040895|FD-Score:-2.90|P-value:2.56E-4 ID:SGTC_2374|Compound:9071832|FD-Score:2.86|P-value:4.27E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.38|P-value:2.62E-5 ID:SGTC_2413|Compound:inermin|FD-Score:3.94|P-value:2.07E-6 ID:SGTC_2487|Compound:5918373|FD-Score:3.34|P-value:4.78E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:2.87|P-value:4.20E-4 ID:SGTC_2976|Compound:9009005|FD-Score:2.66|P-value:9.91E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.11|P-value:1.40E-4 ID:SGTC_3000|Compound:9075062|FD-Score:2.78|P-value:6.01E-4 ID:SGTC_3215|Compound:9129942|FD-Score:2.88|P-value:3.90E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.09|P-value:1.56E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.14|P-value:1.23E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:5.53|P-value:4.40E-11 ID:SGTC_297|Compound:0986-0032|FD-Score:2.66|P-value:9.82E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.19|P-value:9.84E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:2.91|P-value:3.45E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:4.46|P-value:8.51E-8 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.34|P-value:3.26E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:2.70|P-value:8.24E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:2.92|P-value:3.40E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-2.79|P-value:4.00E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-2.73|P-value:5.35E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:-2.82|P-value:3.54E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.20|P-value:9.24E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:3.31|P-value:5.46E-5 ID:SGTC_732|Compound:3970-1727|FD-Score:3.44|P-value:2.98E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.04|P-value:1.34E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:5.13|P-value:8.85E-10 ID:SGTC_806|Compound:3966-4455|FD-Score:2.77|P-value:6.31E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.07|P-value:1.17E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.26|P-value:4.83E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.08|P-value:1.97E-17 ID:SGTC_1124|Compound:fisetin|FD-Score:2.86|P-value:4.38E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:-2.76|P-value:4.70E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.29|P-value:4.02E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:2.88|P-value:3.97E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:3.22|P-value:8.64E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.21|P-value:5.94E-5 ID:SGTC_1986|Compound:st071812|FD-Score:-2.88|P-value:2.76E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.52|P-value:1.97E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.81|P-value:4.22E-6 ID:SGTC_2019|Compound:4016004|FD-Score:-2.63|P-value:8.04E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.37|P-value:4.20E-5 ID:SGTC_2164|Compound:5685496|FD-Score:4.01|P-value:1.38E-6 ID:SGTC_2217|Compound:6934799|FD-Score:2.67|P-value:9.47E-4 ID:SGTC_2348|Compound:9022543|FD-Score:4.34|P-value:1.89E-7 ID:SGTC_2352|Compound:9027995|FD-Score:-3.59|P-value:8.65E-6 ID:SGTC_2360|Compound:9040895|FD-Score:-2.90|P-value:2.56E-4 ID:SGTC_2374|Compound:9071832|FD-Score:2.86|P-value:4.27E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.38|P-value:2.62E-5 ID:SGTC_2413|Compound:inermin|FD-Score:3.94|P-value:2.07E-6 ID:SGTC_2487|Compound:5918373|FD-Score:3.34|P-value:4.78E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:2.87|P-value:4.20E-4 ID:SGTC_2976|Compound:9009005|FD-Score:2.66|P-value:9.91E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.11|P-value:1.40E-4 ID:SGTC_3000|Compound:9075062|FD-Score:2.78|P-value:6.01E-4 ID:SGTC_3215|Compound:9129942|FD-Score:2.88|P-value:3.90E-4

Top fitness defect scores for YOR238W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_130 0136-0219 5.53 337.7 µM 4.40E-11 5 1.62E-8
2 SGTC_773 4358-1457 5.13 44.6 µM 8.85E-10 19 1.44E-7
3 SGTC_424 splitomicin 4.46 100.0 mM 8.51E-8 10 4.01E-6
4 SGTC_2348 9022543 4.34 33.4 µM 1.89E-7 mitochondrial processes 20 7.18E-6
5 SGTC_2164 5685496 4.01 200.0 µM 1.38E-6 23 3.07E-5
6 SGTC_2413 inermin 3.94 26.1 µM 2.07E-6 55 4.14E-5
7 SGTC_2014 4013930 3.81 200.0 µM 4.22E-6 36 6.98E-5
8 SGTC_1996 st072960 3.52 66.8 µM 1.97E-5 30 2.16E-4
9 SGTC_732 3970-1727 3.44 52.7 µM 2.98E-5 16 2.94E-4
10 SGTC_2125 5246583 3.37 200.0 µM 4.20E-5 tubulin folding & SWR complex 70 3.78E-4
11 SGTC_2487 5918373 3.34 44.0 µM 4.78E-5 40 4.16E-4
12 SGTC_716 1683-5115 3.31 658.0 µM 5.46E-5 46 4.59E-4
13 SGTC_1540 guanosine 3.22 70.6 µM 8.64E-5 23 6.45E-4
14 SGTC_701 4424-0219 3.20 185.0 µM 9.24E-5 calcium & mitochondrial duress 40 6.77E-4
15 SGTC_350 k064-0020 3.19 19.8 µM 9.84E-5 heme requiring 52 7.09E-4
16 SGTC_129 0088-0017 3.14 176.6 µM 1.23E-4 103 8.37E-4
17 SGTC_2978 9011784 3.11 43.0 µM 1.40E-4 72 9.22E-4
18 SGTC_73 0327-0325 3.09 16.2 µM 1.56E-4 DNA damage response 104 9.99E-4
19 SGTC_612 0302-0167 2.92 22.4 µM 3.40E-4 copper-dependent oxidative stress 97 0.00177
20 SGTC_371 0195-0006 2.91 7.4 µM 3.45E-4 62 0.00180

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.248 3.56E-48 YPL121C MEI5 hom Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p
0.238 2.73E-44 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.220 4.73E-38 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.211 3.54E-35 YOR082C_d YOR082C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.211 4.36E-35 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.210 8.01E-35 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.207 7.09E-34 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.202 2.61E-32 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.193 1.38E-29 YBR090C_p YBR090C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.188 4.81E-28 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.188 7.33E-28 YDR242W AMD2 hom Putative amidase
0.186 1.72E-27 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.185 3.97E-27 YOR163W DDP1 hom Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress
0.184 5.77E-27 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.181 5.36E-26 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress