HIPHOP chemogenomics database

YOR239W / ABP140

AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift

Zygosity: Homozygous strain

fixedexpanded
Profile for YOR239W / ABP140

Click on Significant Values for Screen Details

Top fitness defect scores for YOR239W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2877	9040724	5.13	71.4 µM	4.68E-8		2	1.45E-7
2	SGTC_1796	st049173	4.63	110.4 µM	7.38E-7		6	1.86E-6
3	SGTC_457	grayanotoxin iii	4.56	135.0 µM	1.02E-6		39	2.50E-6
4	SGTC_2739	tacrine	4.53	100.9 µM	1.20E-6	heme requiring	10	2.92E-6
5	SGTC_1635	st007035	3.93	42.4 µM	2.21E-5		211	4.31E-5
6	SGTC_758	0868-0029	3.84	16.0 µM	3.30E-5		9	6.24E-5
7	SGTC_3326	9140064	3.78	16.4 µM	4.20E-5		24	7.81E-5
8	SGTC_43	0570-0105	3.65	72.5 µM	7.29E-5	ERG2	115	1.30E-4
9	SGTC_2074	5212007	3.61	75.4 µM	8.67E-5		19	1.53E-4
10	SGTC_361	000s-0510	3.57	1.4 µM	1.02E-4		43	1.78E-4
11	SGTC_1682	st012968	3.57	530.0 nM	1.03E-4		28	1.79E-4
12	SGTC_2316	5844804	3.57	197.4 µM	1.04E-4		50	1.81E-4
13	SGTC_1244	0416-0015	3.46	52.5 µM	1.57E-4	ERG2	58	2.66E-4
14	SGTC_536	3852-0578	3.35	10.6 µM	2.51E-4		51	4.09E-4
15	SGTC_2113	5491891	3.30	107.0 µM	2.97E-4	TSC3-RPN4	48	4.78E-4
16	SGTC_493	zm226600	3.26	134.0 µM	3.52E-4	mitochondrial processes	36	5.60E-4
17	SGTC_1320	1313-0481	3.22	95.3 µM	4.09E-4		43	6.43E-4
18	SGTC_3055	9094636	3.22	49.5 µM	4.10E-4		31	6.44E-4
19	SGTC_2622	2-methoxyxanthone	3.14	59.9 µM	5.45E-4		42	8.39E-4
20	SGTC_875	0709-0210	3.14	25.7 µM	5.56E-4	fatty acid desaturase (OLE1)	64	8.55E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.146	1.66E-17	YNR018W	RCF2	hom	Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.114	4.27E-11	YDR042C_p	YDR042C_p	hom	Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
0.112	9.43E-11	YPL165C	SET6	hom	SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability
0.111	1.19E-10	YPL012W	RRP12	het	Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats
0.108	2.95E-10	YMR151W_d	YIM2_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.108	3.43E-10	YJL135W_d	YJL135W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.105	9.36E-10	YDR511W	ACN9	hom	Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes
0.105	1.18E-9	YDL190C	UFD2	hom	Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3
0.104	1.69E-9	YGR183C	QCR9	hom	Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.103	2.06E-9	YEL059C-A	SOM1	hom	Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.101	4.28E-9	YGL191W	COX13	hom	Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.098	1.21E-8	YKL087C	CYT2	hom	Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.095	3.92E-8	YOR047C	STD1	hom	Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.093	6.54E-8	YPL189C-A	COA2	hom	Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.092	8.21E-8	YKL155C	RSM22	hom	Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase