YOR239W / ABP140

AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR239W / ABP140

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:-3.21|P-value:3.89E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.65|P-value:7.29E-5 ID:SGTC_252|Compound:miconazole|FD-Score:-3.35|P-value:2.35E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.42|P-value:1.71E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.57|P-value:1.02E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.56|P-value:1.02E-6 ID:SGTC_493|Compound:zm226600|FD-Score:3.26|P-value:3.52E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.35|P-value:2.51E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.41|P-value:1.85E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.84|P-value:3.30E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:3.14|P-value:5.56E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.63|P-value:7.55E-5 ID:SGTC_1152|Compound:3909-8331|FD-Score:-3.20|P-value:4.15E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-4.77|P-value:3.18E-7 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.46|P-value:1.57E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.22|P-value:4.09E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:-3.48|P-value:1.38E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.06|P-value:7.27E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.93|P-value:2.21E-5 ID:SGTC_1676|Compound:st018489|FD-Score:-3.15|P-value:4.96E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.57|P-value:1.03E-4 ID:SGTC_1763|Compound:st044482|FD-Score:3.08|P-value:6.73E-4 ID:SGTC_1769|Compound:st044406|FD-Score:-3.14|P-value:5.05E-4 ID:SGTC_1796|Compound:st049173|FD-Score:4.63|P-value:7.38E-7 ID:SGTC_1836|Compound:st055642|FD-Score:-4.09|P-value:9.71E-6 ID:SGTC_2074|Compound:5212007|FD-Score:3.61|P-value:8.67E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.30|P-value:2.97E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.57|P-value:1.04E-4 ID:SGTC_2317|Compound:5986382|FD-Score:3.10|P-value:6.46E-4 ID:SGTC_2341|Compound:7987486|FD-Score:-3.83|P-value:3.10E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.06|P-value:6.81E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.85|P-value:2.82E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.14|P-value:5.45E-4 ID:SGTC_2712|Compound:st079126|FD-Score:-3.63|P-value:7.36E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:4.53|P-value:1.20E-6 ID:SGTC_2782|Compound:7736369|FD-Score:-3.17|P-value:4.60E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-4.25|P-value:4.48E-6 ID:SGTC_2823|Compound:7987624|FD-Score:-6.44|P-value:8.63E-12 ID:SGTC_2877|Compound:9040724|FD-Score:5.13|P-value:4.68E-8 ID:SGTC_3055|Compound:9094636|FD-Score:3.22|P-value:4.10E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.36|P-value:2.25E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.78|P-value:4.20E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.21|P-value:3.89E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.65|P-value:7.29E-5 ID:SGTC_252|Compound:miconazole|FD-Score:-3.35|P-value:2.35E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.42|P-value:1.71E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.57|P-value:1.02E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.56|P-value:1.02E-6 ID:SGTC_493|Compound:zm226600|FD-Score:3.26|P-value:3.52E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.35|P-value:2.51E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.41|P-value:1.85E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.84|P-value:3.30E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:3.14|P-value:5.56E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.63|P-value:7.55E-5 ID:SGTC_1152|Compound:3909-8331|FD-Score:-3.20|P-value:4.15E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-4.77|P-value:3.18E-7 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.46|P-value:1.57E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.22|P-value:4.09E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:-3.48|P-value:1.38E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.06|P-value:7.27E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.93|P-value:2.21E-5 ID:SGTC_1676|Compound:st018489|FD-Score:-3.15|P-value:4.96E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.57|P-value:1.03E-4 ID:SGTC_1763|Compound:st044482|FD-Score:3.08|P-value:6.73E-4 ID:SGTC_1769|Compound:st044406|FD-Score:-3.14|P-value:5.05E-4 ID:SGTC_1796|Compound:st049173|FD-Score:4.63|P-value:7.38E-7 ID:SGTC_1836|Compound:st055642|FD-Score:-4.09|P-value:9.71E-6 ID:SGTC_2074|Compound:5212007|FD-Score:3.61|P-value:8.67E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.30|P-value:2.97E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.57|P-value:1.04E-4 ID:SGTC_2317|Compound:5986382|FD-Score:3.10|P-value:6.46E-4 ID:SGTC_2341|Compound:7987486|FD-Score:-3.83|P-value:3.10E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.06|P-value:6.81E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.85|P-value:2.82E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.14|P-value:5.45E-4 ID:SGTC_2712|Compound:st079126|FD-Score:-3.63|P-value:7.36E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:4.53|P-value:1.20E-6 ID:SGTC_2782|Compound:7736369|FD-Score:-3.17|P-value:4.60E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-4.25|P-value:4.48E-6 ID:SGTC_2823|Compound:7987624|FD-Score:-6.44|P-value:8.63E-12 ID:SGTC_2877|Compound:9040724|FD-Score:5.13|P-value:4.68E-8 ID:SGTC_3055|Compound:9094636|FD-Score:3.22|P-value:4.10E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.36|P-value:2.25E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.78|P-value:4.20E-5

Top fitness defect scores for YOR239W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2877 9040724 5.13 71.4 µM 4.68E-8 2 1.45E-7
2 SGTC_1796 st049173 4.63 110.4 µM 7.38E-7 6 1.86E-6
3 SGTC_457 grayanotoxin iii 4.56 135.0 µM 1.02E-6 39 2.50E-6
4 SGTC_2739 tacrine 4.53 100.9 µM 1.20E-6 heme requiring 10 2.92E-6
5 SGTC_1635 st007035 3.93 42.4 µM 2.21E-5 211 4.31E-5
6 SGTC_758 0868-0029 3.84 16.0 µM 3.30E-5 9 6.24E-5
7 SGTC_3326 9140064 3.78 16.4 µM 4.20E-5 24 7.81E-5
8 SGTC_43 0570-0105 3.65 72.5 µM 7.29E-5 ERG2 115 1.30E-4
9 SGTC_2074 5212007 3.61 75.4 µM 8.67E-5 19 1.53E-4
10 SGTC_361 000s-0510 3.57 1.4 µM 1.02E-4 43 1.78E-4
11 SGTC_1682 st012968 3.57 530.0 nM 1.03E-4 28 1.79E-4
12 SGTC_2316 5844804 3.57 197.4 µM 1.04E-4 50 1.81E-4
13 SGTC_1244 0416-0015 3.46 52.5 µM 1.57E-4 ERG2 58 2.66E-4
14 SGTC_536 3852-0578 3.35 10.6 µM 2.51E-4 51 4.09E-4
15 SGTC_2113 5491891 3.30 107.0 µM 2.97E-4 TSC3-RPN4 48 4.78E-4
16 SGTC_493 zm226600 3.26 134.0 µM 3.52E-4 mitochondrial processes 36 5.60E-4
17 SGTC_1320 1313-0481 3.22 95.3 µM 4.09E-4 43 6.43E-4
18 SGTC_3055 9094636 3.22 49.5 µM 4.10E-4 31 6.44E-4
19 SGTC_2622 2-methoxyxanthone 3.14 59.9 µM 5.45E-4 42 8.39E-4
20 SGTC_875 0709-0210 3.14 25.7 µM 5.56E-4 fatty acid desaturase (OLE1) 64 8.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 1.66E-17 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.114 4.27E-11 YDR042C_p YDR042C_p hom Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
0.112 9.43E-11 YPL165C SET6 hom SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability
0.111 1.19E-10 YPL012W RRP12 het Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats
0.108 2.95E-10 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.108 3.43E-10 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.105 9.36E-10 YDR511W ACN9 hom Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes
0.105 1.18E-9 YDL190C UFD2 hom Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3
0.104 1.69E-9 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.103 2.06E-9 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.101 4.28E-9 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.098 1.21E-8 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.095 3.92E-8 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.093 6.54E-8 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.092 8.21E-8 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase