YOR266W / PNT1

Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR266W / PNT1

Click on Significant Values for Screen Details ID:SGTC_163|Compound:1327-0036|FD-Score:2.71|P-value:9.89E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.46|P-value:3.88E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:3.04|P-value:2.60E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.68|P-value:1.25E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:-3.03|P-value:2.57E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.65|P-value:1.43E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.16|P-value:1.53E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.16|P-value:1.55E-4 ID:SGTC_918|Compound:glabranin|FD-Score:2.77|P-value:7.93E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:2.73|P-value:9.27E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:2.97|P-value:3.50E-4 ID:SGTC_1521|Compound:st012942|FD-Score:2.97|P-value:3.50E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-2.77|P-value:7.54E-4 ID:SGTC_1853|Compound:st056710|FD-Score:-2.72|P-value:9.06E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.06|P-value:2.39E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.57|P-value:2.35E-5 ID:SGTC_2087|Compound:5276107|FD-Score:-2.90|P-value:4.43E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.03|P-value:2.71E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-2.77|P-value:7.35E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-4.67|P-value:4.50E-8 ID:SGTC_2343|Compound:7990716|FD-Score:-2.87|P-value:5.05E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:2.74|P-value:8.79E-4 ID:SGTC_2393|Compound:9031399|FD-Score:2.72|P-value:9.61E-4 ID:SGTC_2398|Compound:5228213|FD-Score:2.95|P-value:3.85E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.25|P-value:9.74E-5 ID:SGTC_2485|Compound:5633444|FD-Score:4.34|P-value:3.68E-7 ID:SGTC_2533|Compound:agelasine|FD-Score:4.36|P-value:3.21E-7 ID:SGTC_2709|Compound:st078560|FD-Score:2.82|P-value:6.39E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.12|P-value:1.76E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-2.76|P-value:7.73E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.33|P-value:7.42E-5 ID:SGTC_2792|Compound:7535235|FD-Score:-2.90|P-value:4.39E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-3.11|P-value:1.83E-4 ID:SGTC_3078|Compound:9116413|FD-Score:2.90|P-value:4.76E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-3.61|P-value:1.79E-5 ID:SGTC_3315|Compound:9136395|FD-Score:3.07|P-value:2.33E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-2.73|P-value:8.81E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:2.71|P-value:9.89E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.46|P-value:3.88E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:3.04|P-value:2.60E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.68|P-value:1.25E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:-3.03|P-value:2.57E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.65|P-value:1.43E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.16|P-value:1.53E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.16|P-value:1.55E-4 ID:SGTC_918|Compound:glabranin|FD-Score:2.77|P-value:7.93E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:2.73|P-value:9.27E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:2.97|P-value:3.50E-4 ID:SGTC_1521|Compound:st012942|FD-Score:2.97|P-value:3.50E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-2.77|P-value:7.54E-4 ID:SGTC_1853|Compound:st056710|FD-Score:-2.72|P-value:9.06E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.06|P-value:2.39E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.57|P-value:2.35E-5 ID:SGTC_2087|Compound:5276107|FD-Score:-2.90|P-value:4.43E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.03|P-value:2.71E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-2.77|P-value:7.35E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-4.67|P-value:4.50E-8 ID:SGTC_2343|Compound:7990716|FD-Score:-2.87|P-value:5.05E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:2.74|P-value:8.79E-4 ID:SGTC_2393|Compound:9031399|FD-Score:2.72|P-value:9.61E-4 ID:SGTC_2398|Compound:5228213|FD-Score:2.95|P-value:3.85E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.25|P-value:9.74E-5 ID:SGTC_2485|Compound:5633444|FD-Score:4.34|P-value:3.68E-7 ID:SGTC_2533|Compound:agelasine|FD-Score:4.36|P-value:3.21E-7 ID:SGTC_2709|Compound:st078560|FD-Score:2.82|P-value:6.39E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.12|P-value:1.76E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-2.76|P-value:7.73E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.33|P-value:7.42E-5 ID:SGTC_2792|Compound:7535235|FD-Score:-2.90|P-value:4.39E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-3.11|P-value:1.83E-4 ID:SGTC_3078|Compound:9116413|FD-Score:2.90|P-value:4.76E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-3.61|P-value:1.79E-5 ID:SGTC_3315|Compound:9136395|FD-Score:3.07|P-value:2.33E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-2.73|P-value:8.81E-4

Top fitness defect scores for YOR266W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2533 agelasine 4.36 13.7 µM 3.21E-7 ERG2 44 6.47E-6
2 SGTC_2485 5633444 4.34 17.8 µM 3.68E-7 redox potentiating 31 7.19E-6
3 SGTC_2004 4023728 3.57 41.9 µM 2.35E-5 38 1.80E-4
4 SGTC_182 3448-4371 3.46 550.5 µM 3.88E-5 38 2.67E-4
5 SGTC_2789 5281112 3.33 71.4 µM 7.42E-5 70 4.42E-4
6 SGTC_908 3448-7491 3.16 47.7 µM 1.53E-4 mitochondrial stress 191 7.77E-4
7 SGTC_916 4466-0038 3.16 42.0 nM 1.55E-4 cell wall 123 7.82E-4
8 SGTC_3315 9136395 3.07 68.5 µM 2.33E-4 36 0.00108
9 SGTC_1875 nocodazole 3.06 6.0 µM 2.39E-4 tubulin folding & SWR complex 75 0.00110
10 SGTC_301 4119-0100 3.04 24.5 µM 2.60E-4 NEO1 131 0.00117
11 SGTC_2102 5377816 3.03 72.8 µM 2.71E-4 59 0.00121
12 SGTC_1507 4075-3230 2.97 155.0 µM 3.50E-4 35 0.00148
13 SGTC_1521 st012942 2.97 49.4 µM 3.50E-4 95 0.00148
14 SGTC_2398 5228213 2.95 48.8 µM 3.85E-4 iron homeostasis 112 0.00159
15 SGTC_3078 9116413 2.90 49.5 µM 4.76E-4 unfolded protein response 85 0.00188
16 SGTC_2709 st078560 2.82 56.0 µM 6.39E-4 50 0.00237
17 SGTC_918 glabranin 2.77 770.7 nM 7.93E-4 95 0.00280
18 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 2.74 200.0 µM 8.79E-4 67 0.00304
19 SGTC_945 3381-0768 2.73 11.3 µM 9.27E-4 endomembrane recycling 105 0.00317
20 SGTC_2393 9031399 2.72 185.9 µM 9.61E-4 RNA processing & uracil transport 107 0.00326

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 4.82E-14 YBR115C LYS2 hom Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
0.130 5.02E-14 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.128 1.21E-13 YIL078W THS1 het Threonyl-tRNA synthetase, essential cytoplasmic protein
0.123 9.58E-13 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.120 2.57E-12 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.114 3.33E-11 YDL154W MSH5 hom Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans
0.113 5.12E-11 YER104W RTT105 het Protein with a role in regulation of Ty1 transposition
0.111 1.34E-10 YER028C MIG3 hom Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication
0.110 1.78E-10 YAL068C PAU8 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
0.104 1.60E-9 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.102 2.75E-9 YIL132C CSM2 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis
0.102 3.04E-9 YKR030W GMH1 hom Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
0.094 5.07E-8 YML058W SML1 hom Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
0.094 5.68E-8 YKL214C YRA2 hom Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus
0.093 5.82E-8 YLR002C NOC3 het Component of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing