YOR267C / HRK1

Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR267C / HRK1

Click on Significant Values for Screen Details ID:SGTC_266|Compound:formosanin C|FD-Score:5.20|P-value:2.05E-10 ID:SGTC_289|Compound:k017-0060|FD-Score:-4.28|P-value:1.18E-7 ID:SGTC_324|Compound:1315-0088|FD-Score:-2.91|P-value:2.25E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.17|P-value:2.50E-7 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.40|P-value:2.06E-5 ID:SGTC_489|Compound:paxilline|FD-Score:2.59|P-value:9.49E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:2.77|P-value:4.34E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:4.50|P-value:3.23E-8 ID:SGTC_525|Compound:k781-2675|FD-Score:-2.70|P-value:5.66E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-2.65|P-value:6.82E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.23|P-value:4.78E-5 ID:SGTC_552|Compound:k242-0005|FD-Score:2.72|P-value:5.34E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:-2.78|P-value:4.01E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:-2.77|P-value:4.20E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.40|P-value:2.03E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:2.77|P-value:4.45E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.46|P-value:1.47E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:2.89|P-value:2.61E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.58|P-value:8.63E-6 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.15|P-value:7.19E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.03|P-value:1.34E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:2.83|P-value:3.41E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.63|P-value:6.45E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.09|P-value:4.09E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.15|P-value:7.14E-5 ID:SGTC_1531|Compound:st059297|FD-Score:-2.61|P-value:8.18E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-2.62|P-value:7.70E-4 ID:SGTC_1966|Compound:st070145|FD-Score:-2.71|P-value:5.43E-4 ID:SGTC_2002|Compound:4023503|FD-Score:2.70|P-value:5.84E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.85|P-value:3.15E-4 ID:SGTC_2083|Compound:5306046|FD-Score:-3.30|P-value:3.41E-5 ID:SGTC_2172|Compound:5754775|FD-Score:-2.65|P-value:6.80E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:2.91|P-value:2.41E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.71|P-value:4.05E-6 ID:SGTC_2676|Compound:harmalol|FD-Score:3.29|P-value:3.83E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-3.40|P-value:2.03E-5 ID:SGTC_2989|Compound:9073649|FD-Score:2.67|P-value:6.82E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-2.62|P-value:7.73E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.83|P-value:2.13E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:5.20|P-value:2.05E-10 ID:SGTC_289|Compound:k017-0060|FD-Score:-4.28|P-value:1.18E-7 ID:SGTC_324|Compound:1315-0088|FD-Score:-2.91|P-value:2.25E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.17|P-value:2.50E-7 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.40|P-value:2.06E-5 ID:SGTC_489|Compound:paxilline|FD-Score:2.59|P-value:9.49E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:2.77|P-value:4.34E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:4.50|P-value:3.23E-8 ID:SGTC_525|Compound:k781-2675|FD-Score:-2.70|P-value:5.66E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-2.65|P-value:6.82E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.23|P-value:4.78E-5 ID:SGTC_552|Compound:k242-0005|FD-Score:2.72|P-value:5.34E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:-2.78|P-value:4.01E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:-2.77|P-value:4.20E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.40|P-value:2.03E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:2.77|P-value:4.45E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.46|P-value:1.47E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:2.89|P-value:2.61E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.58|P-value:8.63E-6 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.15|P-value:7.19E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.03|P-value:1.34E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:2.83|P-value:3.41E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.63|P-value:6.45E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.09|P-value:4.09E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.15|P-value:7.14E-5 ID:SGTC_1531|Compound:st059297|FD-Score:-2.61|P-value:8.18E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-2.62|P-value:7.70E-4 ID:SGTC_1966|Compound:st070145|FD-Score:-2.71|P-value:5.43E-4 ID:SGTC_2002|Compound:4023503|FD-Score:2.70|P-value:5.84E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.85|P-value:3.15E-4 ID:SGTC_2083|Compound:5306046|FD-Score:-3.30|P-value:3.41E-5 ID:SGTC_2172|Compound:5754775|FD-Score:-2.65|P-value:6.80E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:2.91|P-value:2.41E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.71|P-value:4.05E-6 ID:SGTC_2676|Compound:harmalol|FD-Score:3.29|P-value:3.83E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-3.40|P-value:2.03E-5 ID:SGTC_2989|Compound:9073649|FD-Score:2.67|P-value:6.82E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-2.62|P-value:7.73E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.83|P-value:2.13E-6

Top fitness defect scores for YOR267C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_266 formosanin C 5.20 406.0 nM 2.05E-10 sphingolipid biosynthesis & PDR1 43 1.01E-7
2 SGTC_523 1934-0222 4.50 13.7 µM 3.23E-8 22 3.47E-6
3 SGTC_3309 9129340 3.83 25.8 µM 2.13E-6 18 6.52E-5
4 SGTC_2654 protoveratrine a 3.71 100.0 µM 4.05E-6 10 1.03E-4
5 SGTC_1359 1582-0056 3.63 520.0 nM 6.45E-6 28 1.42E-4
6 SGTC_1234 0326-0494 3.58 15.5 µM 8.63E-6 24 1.75E-4
7 SGTC_2676 harmalol 3.29 100.0 µM 3.83E-5 mitochondrial processes 30 4.99E-4
8 SGTC_1263 0774-1208 3.03 64.8 µM 1.34E-4 110 0.00121
9 SGTC_2653 dihydrofissinolide 2.91 100.0 µM 2.41E-4 30 0.00184
10 SGTC_1229 0139-0193 2.89 12.2 µM 2.61E-4 RSC complex & mRNA processing 58 0.00194
11 SGTC_2014 4013930 2.85 200.0 µM 3.15E-4 106 0.00222
12 SGTC_1282 0886-0010 2.83 32.4 µM 3.41E-4 endomembrane recycling 83 0.00234
13 SGTC_501 nsc-95397 2.77 161.0 µM 4.34E-4 56 0.00278
14 SGTC_1006 4099-6547 2.77 255.0 µM 4.45E-4 99 0.00283
15 SGTC_552 k242-0005 2.72 476.0 µM 5.34E-4 74 0.00322
16 SGTC_2002 4023503 2.70 131.0 µM 5.84E-4 mitochondrial processes 117 0.00344
17 SGTC_2989 9073649 2.67 71.4 µM 6.82E-4 137 0.00384
18 SGTC_489 paxilline 2.59 115.0 µM 9.49E-4 PDR1 89 0.00486
19 SGTC_1262 0737-0114 2.51 49.6 µM 0.00129 129 0.00605
20 SGTC_634 1611-4317 2.50 11.2 µM 0.00136 ERG2 114 0.00628

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.261 3.85E-53 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.222 1.28E-38 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.219 7.11E-38 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.216 8.87E-37 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.214 4.14E-36 YMR137C PSO2 hom Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress
0.210 1.09E-34 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.209 1.74E-34 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.203 2.67E-32 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.200 1.65E-31 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.197 7.75E-31 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.197 1.13E-30 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.192 4.47E-29 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.185 2.89E-27 YDL234C GYP7 hom GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
0.185 3.96E-27 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.179 1.29E-25 YJR153W PGU1 hom Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins