YOR268C_p

Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR268C / YOR268C

Click on Significant Values for Screen Details ID:SGTC_34|Compound:0469-0683|FD-Score:-2.85|P-value:3.77E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:2.73|P-value:5.44E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:4.18|P-value:3.06E-7 ID:SGTC_69|Compound:0096-0274|FD-Score:3.48|P-value:1.62E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-2.87|P-value:3.57E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:2.87|P-value:3.05E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-2.81|P-value:4.60E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.54|P-value:1.16E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.73|P-value:6.37E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.13|P-value:1.10E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:2.73|P-value:5.39E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.37|P-value:2.85E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:-2.70|P-value:7.05E-4 ID:SGTC_1661|Compound:st013063|FD-Score:-2.83|P-value:4.10E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-3.51|P-value:1.68E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.00|P-value:1.70E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.17|P-value:9.01E-5 ID:SGTC_1882|Compound:5615643|FD-Score:2.60|P-value:9.20E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.81|P-value:3.88E-4 ID:SGTC_2127|Compound:5253358|FD-Score:2.85|P-value:3.21E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.15|P-value:3.64E-7 ID:SGTC_2237|Compound:6667747|FD-Score:3.04|P-value:1.40E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.09|P-value:1.12E-4 ID:SGTC_2391|Compound:6285546|FD-Score:2.62|P-value:8.52E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-2.98|P-value:2.14E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.02|P-value:1.55E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.96|P-value:1.12E-6 ID:SGTC_2814|Compound:7977482|FD-Score:4.27|P-value:1.69E-7 ID:SGTC_2918|Compound:7977171|FD-Score:3.12|P-value:9.75E-5 ID:SGTC_2919|Compound:7978188|FD-Score:2.94|P-value:2.19E-4 ID:SGTC_3011|Compound:9081274|FD-Score:2.73|P-value:5.44E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:-2.85|P-value:3.77E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:2.73|P-value:5.44E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:4.18|P-value:3.06E-7 ID:SGTC_69|Compound:0096-0274|FD-Score:3.48|P-value:1.62E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-2.87|P-value:3.57E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:2.87|P-value:3.05E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-2.81|P-value:4.60E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.54|P-value:1.16E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.73|P-value:6.37E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.13|P-value:1.10E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:2.73|P-value:5.39E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.37|P-value:2.85E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:-2.70|P-value:7.05E-4 ID:SGTC_1661|Compound:st013063|FD-Score:-2.83|P-value:4.10E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-3.51|P-value:1.68E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.00|P-value:1.70E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.17|P-value:9.01E-5 ID:SGTC_1882|Compound:5615643|FD-Score:2.60|P-value:9.20E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.81|P-value:3.88E-4 ID:SGTC_2127|Compound:5253358|FD-Score:2.85|P-value:3.21E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.15|P-value:3.64E-7 ID:SGTC_2237|Compound:6667747|FD-Score:3.04|P-value:1.40E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.09|P-value:1.12E-4 ID:SGTC_2391|Compound:6285546|FD-Score:2.62|P-value:8.52E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-2.98|P-value:2.14E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.02|P-value:1.55E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.96|P-value:1.12E-6 ID:SGTC_2814|Compound:7977482|FD-Score:4.27|P-value:1.69E-7 ID:SGTC_2918|Compound:7977171|FD-Score:3.12|P-value:9.75E-5 ID:SGTC_2919|Compound:7978188|FD-Score:2.94|P-value:2.19E-4 ID:SGTC_3011|Compound:9081274|FD-Score:2.73|P-value:5.44E-4

Top fitness defect scores for YOR268C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2814 7977482 4.27 43.0 µM 1.69E-7 41 9.60E-6
2 SGTC_65 0798-0905 4.18 35.0 µM 3.06E-7 calcium & mitochondrial duress 81 1.46E-5
3 SGTC_2130 NSC 7 4.15 2.5 µM 3.64E-7 copper-dependent oxidative stress 20 1.66E-5
4 SGTC_2625 euphol 3.96 100.0 µM 1.12E-6 28 3.72E-5
5 SGTC_964 1287-0107 3.54 19.4 µM 1.16E-5 cell wall 63 1.98E-4
6 SGTC_69 0096-0274 3.48 206.7 µM 1.62E-5 mitochondrial processes 68 2.51E-4
7 SGTC_1263 0774-1208 3.37 64.8 µM 2.85E-5 71 3.77E-4
8 SGTC_2918 7977171 3.12 22.1 µM 9.75E-5 51 9.14E-4
9 SGTC_2384 9036245 3.09 200.0 µM 1.12E-4 66 0.00101
10 SGTC_2237 6667747 3.04 47.2 µM 1.40E-4 44 0.00118
11 SGTC_2576 guaiol 3.02 23.1 µM 1.55E-4 80 0.00128
12 SGTC_1875 nocodazole 3.00 6.0 µM 1.70E-4 tubulin folding & SWR complex 80 0.00136
13 SGTC_2919 7978188 2.94 46.4 µM 2.19E-4 74 0.00164
14 SGTC_911 3456-4043 2.87 236.0 µM 3.05E-4 mitochondrial processes 96 0.00208
15 SGTC_2127 5253358 2.85 187.9 µM 3.21E-4 74 0.00216
16 SGTC_2126 5251174 2.81 33.9 µM 3.88E-4 128 0.00247
17 SGTC_1234 0326-0494 2.73 15.5 µM 5.39E-4 68 0.00314
18 SGTC_3011 9081274 2.73 71.4 µM 5.44E-4 81 0.00316
19 SGTC_39 0986-0283 2.73 58.4 µM 5.44E-4 calcium & mitochondrial duress 110 0.00316
20 SGTC_2391 6285546 2.62 200.0 µM 8.52E-4 108 0.00437

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.230 2.34E-41 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.211 5.66E-35 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.188 6.37E-28 YDR020C_p DAS2_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
0.176 1.12E-24 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.175 1.29E-24 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.171 2.65E-23 YLR112W_d YLR112W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.165 7.15E-22 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.164 1.47E-21 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.157 4.61E-20 YJL150W_d YJL150W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.153 6.10E-19 YBR204C LDH1 hom Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)
0.151 1.39E-18 YDL121C_p YDL121C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein
0.144 6.42E-17 YBR214W SDS24 hom Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication
0.141 1.94E-16 YBR156C SLI15 hom Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly
0.137 2.03E-15 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.135 5.46E-15 YDR162C NBP2 hom Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)