YOR278W / HEM4

Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR278W / HEM4

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.77|P-value:2.49E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:3.71|P-value:3.07E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.51|P-value:6.04E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:4.67|P-value:8.13E-6 ID:SGTC_126|Compound:0417-1624|FD-Score:4.50|P-value:1.62E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.64|P-value:3.90E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.80|P-value:2.26E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.40|P-value:8.54E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.39|P-value:8.84E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.45|P-value:6.12E-4 ID:SGTC_470|Compound:aa-861|FD-Score:5.06|P-value:1.43E-6 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:5.56|P-value:1.34E-7 ID:SGTC_512|Compound:prima-1|FD-Score:5.10|P-value:1.23E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:4.70|P-value:7.03E-6 ID:SGTC_578|Compound:3460-0051|FD-Score:4.40|P-value:2.40E-5 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.34|P-value:8.66E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:4.18|P-value:5.70E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:3.93|P-value:1.43E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.63|P-value:4.12E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:-4.06|P-value:7.38E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.10|P-value:7.65E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:-4.28|P-value:3.09E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:-3.32|P-value:9.40E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:4.07|P-value:8.67E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.56|P-value:5.21E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.37|P-value:2.69E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.48|P-value:1.75E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.74|P-value:2.80E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.53|P-value:1.41E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:-3.93|P-value:1.18E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.68|P-value:7.67E-8 ID:SGTC_1889|Compound:st059080|FD-Score:-4.09|P-value:6.45E-5 ID:SGTC_2074|Compound:5212007|FD-Score:-3.31|P-value:9.50E-4 ID:SGTC_2108|Compound:5365811|FD-Score:-3.53|P-value:4.71E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.71|P-value:6.87E-6 ID:SGTC_2323|Compound:6148992|FD-Score:4.46|P-value:1.87E-5 ID:SGTC_2340|Compound:7987427|FD-Score:-3.30|P-value:9.94E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.36|P-value:8.30E-4 ID:SGTC_2394|Compound:5221648|FD-Score:4.51|P-value:1.55E-5 ID:SGTC_2397|Compound:5161689|FD-Score:-4.60|P-value:8.70E-6 ID:SGTC_2402|Compound:5553605|FD-Score:3.63|P-value:4.08E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.47|P-value:5.71E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.98|P-value:9.80E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:6.51|P-value:8.57E-10 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.02|P-value:1.03E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:-4.49|P-value:1.33E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-6.37|P-value:1.42E-9 ID:SGTC_2832|Compound:7992762|FD-Score:5.05|P-value:1.55E-6 ID:SGTC_2834|Compound:9001755|FD-Score:4.78|P-value:5.01E-6 ID:SGTC_2849|Compound:9019321|FD-Score:-3.57|P-value:4.18E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-5.14|P-value:7.82E-7 ID:SGTC_2921|Compound:7974240|FD-Score:-4.01|P-value:8.80E-5 ID:SGTC_2926|Compound:9010726|FD-Score:3.81|P-value:2.21E-4 ID:SGTC_3149|Compound:9097855|FD-Score:5.14|P-value:1.03E-6 ID:SGTC_3244|Compound:9134489|FD-Score:3.67|P-value:3.55E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.77|P-value:2.49E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:3.71|P-value:3.07E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.51|P-value:6.04E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:4.67|P-value:8.13E-6 ID:SGTC_126|Compound:0417-1624|FD-Score:4.50|P-value:1.62E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.64|P-value:3.90E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.80|P-value:2.26E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.40|P-value:8.54E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.39|P-value:8.84E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.45|P-value:6.12E-4 ID:SGTC_470|Compound:aa-861|FD-Score:5.06|P-value:1.43E-6 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:5.56|P-value:1.34E-7 ID:SGTC_512|Compound:prima-1|FD-Score:5.10|P-value:1.23E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:4.70|P-value:7.03E-6 ID:SGTC_578|Compound:3460-0051|FD-Score:4.40|P-value:2.40E-5 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.34|P-value:8.66E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:4.18|P-value:5.70E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:3.93|P-value:1.43E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.63|P-value:4.12E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:-4.06|P-value:7.38E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.10|P-value:7.65E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:-4.28|P-value:3.09E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:-3.32|P-value:9.40E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:4.07|P-value:8.67E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.56|P-value:5.21E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.37|P-value:2.69E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.48|P-value:1.75E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.74|P-value:2.80E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.53|P-value:1.41E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:-3.93|P-value:1.18E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.68|P-value:7.67E-8 ID:SGTC_1889|Compound:st059080|FD-Score:-4.09|P-value:6.45E-5 ID:SGTC_2074|Compound:5212007|FD-Score:-3.31|P-value:9.50E-4 ID:SGTC_2108|Compound:5365811|FD-Score:-3.53|P-value:4.71E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.71|P-value:6.87E-6 ID:SGTC_2323|Compound:6148992|FD-Score:4.46|P-value:1.87E-5 ID:SGTC_2340|Compound:7987427|FD-Score:-3.30|P-value:9.94E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.36|P-value:8.30E-4 ID:SGTC_2394|Compound:5221648|FD-Score:4.51|P-value:1.55E-5 ID:SGTC_2397|Compound:5161689|FD-Score:-4.60|P-value:8.70E-6 ID:SGTC_2402|Compound:5553605|FD-Score:3.63|P-value:4.08E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.47|P-value:5.71E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.98|P-value:9.80E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:6.51|P-value:8.57E-10 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.02|P-value:1.03E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:-4.49|P-value:1.33E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-6.37|P-value:1.42E-9 ID:SGTC_2832|Compound:7992762|FD-Score:5.05|P-value:1.55E-6 ID:SGTC_2834|Compound:9001755|FD-Score:4.78|P-value:5.01E-6 ID:SGTC_2849|Compound:9019321|FD-Score:-3.57|P-value:4.18E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-5.14|P-value:7.82E-7 ID:SGTC_2921|Compound:7974240|FD-Score:-4.01|P-value:8.80E-5 ID:SGTC_2926|Compound:9010726|FD-Score:3.81|P-value:2.21E-4 ID:SGTC_3149|Compound:9097855|FD-Score:5.14|P-value:1.03E-6 ID:SGTC_3244|Compound:9134489|FD-Score:3.67|P-value:3.55E-4

Top fitness defect scores for YOR278W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2754 granisetron 6.51 64.0 µM 8.57E-10 1 3.78E-11 1.08
2 SGTC_1597 7-benzyloxygramine 5.68 47.5 µM 7.67E-8 calcium & mitochondrial duress 37 6.91E-9 0.11
3 SGTC_471 1-acyl-paf 5.56 4.0 µM 1.34E-7 DNA intercalators 10 1.32E-8 0.32
4 SGTC_3149 9097855 5.14 49.5 µM 1.03E-6 Golgi 5 1.39E-7 0.45
5 SGTC_512 prima-1 5.10 270.0 µM 1.23E-6 DNA intercalators 5 1.72E-7 0.14
6 SGTC_470 aa-861 5.06 153.0 µM 1.43E-6 sphingolipid biosynthesis & PDR1 8 2.05E-7 0.26
7 SGTC_2832 7992762 5.05 52.0 µM 1.55E-6 4 2.25E-7 0.22
8 SGTC_2834 9001755 4.78 58.4 µM 5.01E-6 3 8.74E-7 0.89
9 SGTC_2200 6600604 4.71 21.9 µM 6.87E-6 tubulin folding & SWR complex 3 1.26E-6 0.42
10 SGTC_572 0960-0087 4.70 17.7 µM 7.03E-6 6 1.29E-6 0.27
11 SGTC_125 0133-0007 4.67 11.8 µM 8.13E-6 DNA intercalators 4 1.53E-6 0.29
12 SGTC_1533 dihydroergotamine mesylate 4.53 29.4 µM 1.41E-5 DNA intercalators 4 2.90E-6 0.48
13 SGTC_2394 5221648 4.51 200.0 µM 1.55E-5 3 3.22E-6 0.04
14 SGTC_126 0417-1624 4.50 672.5 µM 1.62E-5 DNA intercalators 10 3.41E-6 0.13
15 SGTC_1459 k035-0031 4.48 35.7 µM 1.75E-5 DNA intercalators 7 3.72E-6 0.01
16 SGTC_2323 6148992 4.46 148.3 µM 1.87E-5 10 4.01E-6 0.10
17 SGTC_578 3460-0051 4.40 92.0 µM 2.40E-5 3 5.35E-6 0.39
18 SGTC_1415 3966-0071 4.37 78.1 µM 2.69E-5 DNA intercalators 8 6.11E-6 0.46
19 SGTC_633 0437-0093 4.18 97.7 µM 5.70E-5 DNA intercalators 7 1.46E-5 0.24
20 SGTC_1107 amlodipine 4.10 47.0 µM 7.65E-5 4 2.05E-5 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.324 1.09E-82 YDL058W USO1 het Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
0.285 1.39E-63 YER003C PMI40 het Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
0.281 1.07E-61 YMR208W ERG12 het Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
0.256 1.61E-51 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.243 2.20E-46 YNL317W PFS2 het Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex
0.231 4.91E-42 YDR060W MAK21 het Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
0.222 7.73E-39 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.215 2.19E-36 YMR119W ASI1 hom Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication
0.215 3.19E-36 YDR458C HEH2 hom Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle
0.212 3.24E-35 YOR294W RRS1 het Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice
0.177 7.24E-25 YDR362C TFC6 het One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110
0.157 7.56E-20 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.152 8.39E-19 YHR172W SPC97 het Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
0.150 2.14E-18 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.146 1.46E-17 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm