HIPHOP chemogenomics database
YOR282W_d 
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
Zygosity: Heterozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YOR282W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.321 | 6.76E-81 | YKL090W | CUE2 | hom | Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination |
| 0.318 | 2.71E-79 | YER074W | RPS24A | hom | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication |
| 0.288 | 6.79E-65 | YHR193C | EGD2 | hom | Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes |
| 0.247 | 1.09E-47 | YJL101C | GSH1 | hom | Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress |
| 0.219 | 1.73E-37 | YNL069C | RPL16B | hom | Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication |
| 0.213 | 1.43E-35 | YCR001W_d | YCR001W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene |
| 0.208 | 1.07E-33 | YBL087C | RPL23A | hom | Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication |
| 0.205 | 4.09E-33 | YGR134W | CAF130 | hom | Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation |
| 0.201 | 5.97E-32 | YBR040W | FIG1 | hom | Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating |
| 0.184 | 8.91E-27 | YMR042W | ARG80 | hom | Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p |
| 0.184 | 7.96E-27 | YHR029C | YHI9 | hom | Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production |
| 0.182 | 3.18E-26 | YPL091W | GLR1 | hom | Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress |
| 0.176 | 1.44E-24 | YFR036W | CDC26 | hom | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition |
| 0.171 | 2.26E-23 | YAL024C | LTE1 | hom | Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures |
| 0.170 | 5.34E-23 | YML073C | RPL6A | hom | Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication |