HIPHOP chemogenomics database
YOR285W / RDL1 
Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YOR285W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.144 | 5.22E-17 | YHR040W | BCD1 | het | Essential protein required for the accumulation of box C/D snoRNA |
| 0.110 | 1.76E-10 | YGR022C_d | YGR022C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W |
| 0.104 | 1.46E-9 | YCL026C-A | FRM2 | hom | Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin |
| 0.100 | 7.04E-9 | YLR300W | EXG1 | hom | Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes |
| 0.098 | 1.32E-8 | YFR052W | RPN12 | het | Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress |
| 0.098 | 1.38E-8 | YKL183W | LOT5 | hom | Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress |
| 0.091 | 1.10E-7 | YLR247C | IRC20 | hom | Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci |
| 0.091 | 1.21E-7 | YKL185W | ASH1 | hom | Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate |
| 0.089 | 2.40E-7 | YKL098W | MTC2 | hom | Protein of unknown function; mtc2 is synthetically sick with cdc13-1 |
| 0.088 | 3.18E-7 | YDL222C | FMP45 | hom | Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C |
| 0.088 | 3.30E-7 | YDL176W | YDL176W | hom | Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene |
| 0.087 | 4.15E-7 | YOR152C_p | YOR152C_p | hom | Putative protein of unknown function; YOR152C is not an essential gene |
| 0.086 | 5.58E-7 | YLR339C_d | YLR339C_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0 |
| 0.086 | 6.87E-7 | YFL040W_p | YFL040W_p | hom | Putative transporter, member of the sugar porter family; YFL040W is not an essential gene |
| 0.084 | 1.15E-6 | YNL047C | SLM2 | hom | Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication |