YOR286W / RDL2

Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR286W / RDL2

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:-6.88|P-value:2.37E-13 ID:SGTC_50|Compound:0929-0078|FD-Score:-7.78|P-value:1.40E-16 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.40|P-value:1.75E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.61|P-value:7.42E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.35|P-value:2.11E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:-3.22|P-value:3.53E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:-3.41|P-value:1.67E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:4.21|P-value:4.83E-6 ID:SGTC_302|Compound:1094-0063|FD-Score:-7.27|P-value:1.05E-14 ID:SGTC_325|Compound:2810-4341|FD-Score:-4.17|P-value:5.71E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.33|P-value:2.36E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:6.12|P-value:6.33E-11 ID:SGTC_624|Compound:k048-0052|FD-Score:3.02|P-value:7.61E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.85|P-value:2.64E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:3.05|P-value:6.84E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.14|P-value:4.90E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.91|P-value:2.02E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:4.58|P-value:7.42E-7 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-5.62|P-value:1.71E-9 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.63|P-value:5.66E-7 ID:SGTC_1112|Compound:tnp00069|FD-Score:-7.01|P-value:8.59E-14 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.27|P-value:3.01E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-2.96|P-value:9.27E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:-3.03|P-value:7.29E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.33|P-value:2.40E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.33|P-value:2.37E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:3.85|P-value:2.59E-5 ID:SGTC_1594|Compound:piperine|FD-Score:3.02|P-value:7.61E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.17|P-value:4.29E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.34|P-value:2.27E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.55|P-value:9.83E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.25|P-value:3.22E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.16|P-value:4.54E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.37|P-value:2.02E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.37|P-value:2.05E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-3.28|P-value:2.79E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-3.07|P-value:6.31E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-4.02|P-value:1.16E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.93|P-value:1.10E-7 ID:SGTC_2171|Compound:5739187|FD-Score:3.11|P-value:5.51E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-5.19|P-value:2.46E-8 ID:SGTC_2260|Compound:7964312|FD-Score:3.27|P-value:3.02E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.15|P-value:4.59E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-3.09|P-value:5.87E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.58|P-value:8.33E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.71|P-value:4.93E-5 ID:SGTC_2523|Compound:spermine|FD-Score:3.04|P-value:7.02E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.34|P-value:2.24E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.57|P-value:8.91E-5 ID:SGTC_2744|Compound:captopril|FD-Score:-2.94|P-value:9.84E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.13|P-value:4.98E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.01|P-value:1.24E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.04|P-value:6.94E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.42|P-value:1.61E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.02|P-value:7.60E-4 ID:SGTC_2867|Compound:9039098|FD-Score:4.25|P-value:4.13E-6 ID:SGTC_2878|Compound:9043973|FD-Score:3.09|P-value:5.93E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.00|P-value:8.06E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.20|P-value:3.83E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.66|P-value:6.06E-5 ID:SGTC_26|Compound:0302-0163|FD-Score:-6.88|P-value:2.37E-13 ID:SGTC_50|Compound:0929-0078|FD-Score:-7.78|P-value:1.40E-16 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.40|P-value:1.75E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.61|P-value:7.42E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.35|P-value:2.11E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:-3.22|P-value:3.53E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:-3.41|P-value:1.67E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:4.21|P-value:4.83E-6 ID:SGTC_302|Compound:1094-0063|FD-Score:-7.27|P-value:1.05E-14 ID:SGTC_325|Compound:2810-4341|FD-Score:-4.17|P-value:5.71E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.33|P-value:2.36E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:6.12|P-value:6.33E-11 ID:SGTC_624|Compound:k048-0052|FD-Score:3.02|P-value:7.61E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.85|P-value:2.64E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:3.05|P-value:6.84E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.14|P-value:4.90E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.91|P-value:2.02E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:4.58|P-value:7.42E-7 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-5.62|P-value:1.71E-9 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.63|P-value:5.66E-7 ID:SGTC_1112|Compound:tnp00069|FD-Score:-7.01|P-value:8.59E-14 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.27|P-value:3.01E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-2.96|P-value:9.27E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:-3.03|P-value:7.29E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.33|P-value:2.40E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.33|P-value:2.37E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:3.85|P-value:2.59E-5 ID:SGTC_1594|Compound:piperine|FD-Score:3.02|P-value:7.61E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.17|P-value:4.29E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.34|P-value:2.27E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.55|P-value:9.83E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.25|P-value:3.22E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.16|P-value:4.54E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.37|P-value:2.02E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.37|P-value:2.05E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-3.28|P-value:2.79E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-3.07|P-value:6.31E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-4.02|P-value:1.16E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.93|P-value:1.10E-7 ID:SGTC_2171|Compound:5739187|FD-Score:3.11|P-value:5.51E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-5.19|P-value:2.46E-8 ID:SGTC_2260|Compound:7964312|FD-Score:3.27|P-value:3.02E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.15|P-value:4.59E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-3.09|P-value:5.87E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.58|P-value:8.33E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.71|P-value:4.93E-5 ID:SGTC_2523|Compound:spermine|FD-Score:3.04|P-value:7.02E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.34|P-value:2.24E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.57|P-value:8.91E-5 ID:SGTC_2744|Compound:captopril|FD-Score:-2.94|P-value:9.84E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.13|P-value:4.98E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.01|P-value:1.24E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.04|P-value:6.94E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.42|P-value:1.61E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.02|P-value:7.60E-4 ID:SGTC_2867|Compound:9039098|FD-Score:4.25|P-value:4.13E-6 ID:SGTC_2878|Compound:9043973|FD-Score:3.09|P-value:5.93E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.00|P-value:8.06E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.20|P-value:3.83E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.66|P-value:6.06E-5

Top fitness defect scores for YOR286W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_542 3381-0244 6.12 89.3 µM 6.33E-11 15 4.59E-10
2 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 4.93 49.5 µM 1.10E-7 9 4.04E-7
3 SGTC_945 3381-0768 4.58 11.3 µM 7.42E-7 endomembrane recycling 20 2.29E-6
4 SGTC_2867 9039098 4.25 71.4 µM 4.13E-6 iron homeostasis 26 1.09E-5
5 SGTC_278 4092-0821 4.21 23.9 µM 4.83E-6 plasma membrane duress 35 1.26E-5
6 SGTC_891 0929-0073 3.91 133.0 µM 2.02E-5 24 4.63E-5
7 SGTC_1540 guanosine 3.85 70.6 µM 2.59E-5 10 5.81E-5
8 SGTC_639 0833-0042 3.85 114.0 µM 2.64E-5 49 5.90E-5
9 SGTC_2488 5268135 3.71 45.7 µM 4.93E-5 60 1.04E-4
10 SGTC_2676 harmalol 3.57 100.0 µM 8.91E-5 mitochondrial processes 21 1.79E-4
11 SGTC_1714 st033236 3.55 13.6 µM 9.83E-5 35 1.96E-4
12 SGTC_1898 st060199 3.37 18.6 µM 2.02E-4 27 3.76E-4
13 SGTC_2004 4023728 3.37 41.9 µM 2.05E-4 49 3.82E-4
14 SGTC_2622 2-methoxyxanthone 3.34 59.9 µM 2.24E-4 32 4.14E-4
15 SGTC_1691 st019933 3.34 84.6 µM 2.27E-4 29 4.19E-4
16 SGTC_481 bay k-8644 3.33 50.0 µM 2.36E-4 43 4.34E-4
17 SGTC_1531 st059297 3.33 52.4 µM 2.37E-4 42 4.37E-4
18 SGTC_1476 4112-3294 3.33 3.3 µM 2.40E-4 60S ribosome export 36 4.42E-4
19 SGTC_1213 1315-0166 3.27 115.0 µM 3.01E-4 50 5.43E-4
20 SGTC_2260 7964312 3.27 200.0 µM 3.02E-4 31 5.44E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.202 3.63E-32 YGL158W RCK1 hom Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication
0.168 1.15E-22 YML021C UNG1 hom Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
0.168 1.29E-22 YJL130C URA2 hom Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
0.112 7.48E-11 YNL305C BXI1 hom Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p
0.106 7.61E-10 YJR031C GEA1 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication
0.098 1.27E-8 YLL051C FRE6 hom Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels
0.090 1.53E-7 YGL039W YGL039W hom Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols
0.089 2.61E-7 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.088 3.09E-7 YOR087W YVC1 hom Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
0.088 3.41E-7 YJL032W_d YJL032W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase
0.086 5.93E-7 YIR038C GTT1 hom ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p
0.085 7.26E-7 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.085 8.05E-7 YFR039C_p YFR039C_p hom Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces
0.081 2.94E-6 YKR045C_p YKR045C_p hom Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
0.079 4.24E-6 YOR080W DIA2 hom Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase