Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOR291W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.232 | 2.63E-42 | YBR138C_p | YBR138C_p | hom | Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene |
0.203 | 1.58E-32 | YBL068W | PRS4 | hom | 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication |
0.165 | 7.88E-22 | YGR109C | CLB6 | hom | B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 |
0.161 | 9.07E-21 | YEL004W | YEA4 | hom | Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER |
0.154 | 2.39E-19 | YNL082W | PMS1 | hom | ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL |
0.154 | 4.10E-19 | YPR185W | ATG13 | hom | Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling |
0.144 | 4.18E-17 | YDR453C | TSA2 | hom | Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress |
0.144 | 5.24E-17 | YHL032C | GUT1 | hom | Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p |
0.140 | 3.13E-16 | YKL100C_p | YKL100C_p | hom | Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene |
0.128 | 1.31E-13 | YPR171W | BSP1 | hom | Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton |
0.126 | 3.03E-13 | YKL015W | PUT3 | hom | Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain |
0.125 | 3.60E-13 | YKL153W_d | YKL153W_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant |
0.124 | 4.76E-13 | YPL159C | PET20 | hom | Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome |
0.124 | 7.06E-13 | YOL078W | AVO1 | het | Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth |
0.122 | 1.13E-12 | YPL263C | KEL3 | hom | Cytoplasmic protein of unknown function |