YOR291W / YPK9

Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR291W / YPK9

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:-3.85|P-value:1.60E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.00|P-value:5.96E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.47|P-value:8.59E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:3.72|P-value:2.88E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:7.27|P-value:1.83E-15 ID:SGTC_714|Compound:4296-0578|FD-Score:-3.71|P-value:3.01E-5 ID:SGTC_719|Compound:2810-4230|FD-Score:-2.88|P-value:9.15E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:-3.04|P-value:5.06E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:4.23|P-value:2.45E-6 ID:SGTC_973|Compound:1325-0077|FD-Score:4.32|P-value:1.48E-6 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.34|P-value:1.54E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-2.87|P-value:9.54E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.04|P-value:4.98E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:2.91|P-value:8.35E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.25|P-value:2.16E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.92|P-value:1.14E-5 ID:SGTC_1299|Compound:1079-1439|FD-Score:-2.87|P-value:9.64E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:-3.18|P-value:3.01E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.18|P-value:2.95E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.06|P-value:4.74E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:-3.09|P-value:4.24E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:-3.35|P-value:1.46E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.15|P-value:3.28E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-2.90|P-value:8.67E-4 ID:SGTC_1917|Compound:st066507|FD-Score:2.94|P-value:7.35E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.23|P-value:2.39E-4 ID:SGTC_2796|Compound:7949634|FD-Score:4.24|P-value:2.26E-6 ID:SGTC_2804|Compound:7954240|FD-Score:-3.62|P-value:4.66E-5 ID:SGTC_2836|Compound:9010338|FD-Score:-3.60|P-value:4.92E-5 ID:SGTC_3008|Compound:9078912|FD-Score:-3.68|P-value:3.49E-5 ID:SGTC_3027|Compound:9089541|FD-Score:2.96|P-value:6.73E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-2.96|P-value:6.90E-4 ID:SGTC_3071|Compound:9117417|FD-Score:3.73|P-value:2.80E-5 ID:SGTC_3202|Compound:9113761|FD-Score:11.30|P-value:2.28E-34 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.85|P-value:1.60E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.00|P-value:5.96E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.47|P-value:8.59E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:3.72|P-value:2.88E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:7.27|P-value:1.83E-15 ID:SGTC_714|Compound:4296-0578|FD-Score:-3.71|P-value:3.01E-5 ID:SGTC_719|Compound:2810-4230|FD-Score:-2.88|P-value:9.15E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:-3.04|P-value:5.06E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:4.23|P-value:2.45E-6 ID:SGTC_973|Compound:1325-0077|FD-Score:4.32|P-value:1.48E-6 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.34|P-value:1.54E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-2.87|P-value:9.54E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.04|P-value:4.98E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:2.91|P-value:8.35E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.25|P-value:2.16E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.92|P-value:1.14E-5 ID:SGTC_1299|Compound:1079-1439|FD-Score:-2.87|P-value:9.64E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:-3.18|P-value:3.01E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.18|P-value:2.95E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.06|P-value:4.74E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:-3.09|P-value:4.24E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:-3.35|P-value:1.46E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.15|P-value:3.28E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-2.90|P-value:8.67E-4 ID:SGTC_1917|Compound:st066507|FD-Score:2.94|P-value:7.35E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.23|P-value:2.39E-4 ID:SGTC_2796|Compound:7949634|FD-Score:4.24|P-value:2.26E-6 ID:SGTC_2804|Compound:7954240|FD-Score:-3.62|P-value:4.66E-5 ID:SGTC_2836|Compound:9010338|FD-Score:-3.60|P-value:4.92E-5 ID:SGTC_3008|Compound:9078912|FD-Score:-3.68|P-value:3.49E-5 ID:SGTC_3027|Compound:9089541|FD-Score:2.96|P-value:6.73E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-2.96|P-value:6.90E-4 ID:SGTC_3071|Compound:9117417|FD-Score:3.73|P-value:2.80E-5 ID:SGTC_3202|Compound:9113761|FD-Score:11.30|P-value:2.28E-34

Top fitness defect scores for YOR291W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3202 9113761 11.30 49.5 µM 2.28E-34 1 1.10E-29
2 SGTC_359 0081-0058 7.27 15.9 µM 1.83E-15 60S ribosome export 6 1.73E-13
3 SGTC_973 1325-0077 4.32 65.9 µM 1.48E-6 4 7.73E-6
4 SGTC_2796 7949634 4.24 45.5 µM 2.26E-6 13 1.11E-5
5 SGTC_865 0488-0499 4.23 301.0 µM 2.45E-6 14 1.19E-5
6 SGTC_3071 9117417 3.73 49.5 µM 2.80E-5 fatty acid desaturase (OLE1) 21 9.74E-5
7 SGTC_342 k048-0088 3.72 23.3 µM 2.88E-5 RSC & ERG11 24 9.99E-5
8 SGTC_271 rotenone 3.47 740.0 µM 8.59E-5 45 2.56E-4
9 SGTC_1226 3909-7979 3.25 35.4 µM 2.16E-4 65 5.69E-4
10 SGTC_2380 9035439 3.23 200.0 µM 2.39E-4 endomembrane recycling 62 6.21E-4
11 SGTC_1381 2324-0066 3.18 62.1 µM 2.95E-4 62 7.44E-4
12 SGTC_1400 3771-8998 3.06 51.5 µM 4.74E-4 30 0.00112
13 SGTC_1096 rimcazole 3.04 32.2 µM 4.98E-4 39 0.00117
14 SGTC_69 0096-0274 3.00 206.7 µM 5.96E-4 mitochondrial processes 107 0.00137
15 SGTC_3027 9089541 2.96 49.5 µM 6.73E-4 fatty acid desaturase (OLE1) 68 0.00152
16 SGTC_1917 st066507 2.94 28.5 µM 7.35E-4 Golgi 104 0.00164
17 SGTC_1126 isoteolin 2.91 1.0 µM 8.35E-4 86 0.00183
18 SGTC_779 1360-0071 2.81 233.0 µM 0.00117 fatty acid desaturase (OLE1) 98 0.00245
19 SGTC_1844 rapamycin 2.77 4.0 nM 0.00137 270 0.00281
20 SGTC_1638 st008370 2.76 60.6 µM 0.00141 ergosterol biosynthesis 99 0.00288

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.232 2.63E-42 YBR138C_p YBR138C_p hom Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
0.203 1.58E-32 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.165 7.88E-22 YGR109C CLB6 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1
0.161 9.07E-21 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.154 2.39E-19 YNL082W PMS1 hom ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL
0.154 4.10E-19 YPR185W ATG13 hom Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling
0.144 4.18E-17 YDR453C TSA2 hom Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress
0.144 5.24E-17 YHL032C GUT1 hom Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
0.140 3.13E-16 YKL100C_p YKL100C_p hom Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene
0.128 1.31E-13 YPR171W BSP1 hom Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
0.126 3.03E-13 YKL015W PUT3 hom Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain
0.125 3.60E-13 YKL153W_d YKL153W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
0.124 4.76E-13 YPL159C PET20 hom Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome
0.124 7.06E-13 YOL078W AVO1 het Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
0.122 1.13E-12 YPL263C KEL3 hom Cytoplasmic protein of unknown function