YOR293C-A_p

Putative protein of unknown function; identified by expression profiling and mass spectrometry

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR293C-A / YOR293C-A

Click on Significant Values for Screen Details ID:SGTC_236|Compound:1509-0011|FD-Score:3.60|P-value:4.79E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:3.99|P-value:7.76E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:3.06|P-value:4.68E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:2.86|P-value:9.83E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.41|P-value:1.10E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:4.11|P-value:4.34E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:3.91|P-value:1.16E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.54|P-value:6.26E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.01|P-value:5.62E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-3.85|P-value:1.63E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:2.91|P-value:8.13E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.07|P-value:5.16E-6 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.49|P-value:8.00E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.87|P-value:9.63E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.63|P-value:5.46E-10 ID:SGTC_1677|Compound:st019204|FD-Score:3.35|P-value:1.41E-4 ID:SGTC_1979|Compound:st071809|FD-Score:2.89|P-value:8.58E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.37|P-value:1.30E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.20|P-value:2.78E-4 ID:SGTC_2113|Compound:5491891|FD-Score:2.94|P-value:7.22E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.21|P-value:2.50E-4 ID:SGTC_2320|Compound:7373003|FD-Score:2.98|P-value:6.33E-4 ID:SGTC_2436|Compound:5633522|FD-Score:-3.14|P-value:3.48E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.65|P-value:3.89E-5 ID:SGTC_2796|Compound:7949634|FD-Score:-3.48|P-value:8.60E-5 ID:SGTC_2934|Compound:9036370|FD-Score:-6.17|P-value:1.30E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:3.60|P-value:4.79E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:3.99|P-value:7.76E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:3.06|P-value:4.68E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:2.86|P-value:9.83E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.41|P-value:1.10E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:4.11|P-value:4.34E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:3.91|P-value:1.16E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.54|P-value:6.26E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.01|P-value:5.62E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-3.85|P-value:1.63E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:2.91|P-value:8.13E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.07|P-value:5.16E-6 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.49|P-value:8.00E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.87|P-value:9.63E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.63|P-value:5.46E-10 ID:SGTC_1677|Compound:st019204|FD-Score:3.35|P-value:1.41E-4 ID:SGTC_1979|Compound:st071809|FD-Score:2.89|P-value:8.58E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.37|P-value:1.30E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.20|P-value:2.78E-4 ID:SGTC_2113|Compound:5491891|FD-Score:2.94|P-value:7.22E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.21|P-value:2.50E-4 ID:SGTC_2320|Compound:7373003|FD-Score:2.98|P-value:6.33E-4 ID:SGTC_2436|Compound:5633522|FD-Score:-3.14|P-value:3.48E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.65|P-value:3.89E-5 ID:SGTC_2796|Compound:7949634|FD-Score:-3.48|P-value:8.60E-5 ID:SGTC_2934|Compound:9036370|FD-Score:-6.17|P-value:1.30E-11

Top fitness defect scores for YOR293C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 5.63 42.4 µM 5.46E-10 141 8.94E-9
2 SGTC_822 1487-0950 4.11 154.0 µM 4.34E-6 9 2.00E-5
3 SGTC_1244 0416-0015 4.07 52.5 µM 5.16E-6 ERG2 30 2.32E-5
4 SGTC_370 0180-0345 3.99 38.7 µM 7.76E-6 DNA intercalators 11 3.29E-5
5 SGTC_979 1426-2828 3.91 121.0 µM 1.16E-5 19 4.65E-5
6 SGTC_2794 7785382 3.65 27.3 µM 3.89E-5 50 1.32E-4
7 SGTC_236 1509-0011 3.60 5.3 µM 4.79E-5 407 1.58E-4
8 SGTC_1029 k015-0030 3.54 64.7 µM 6.26E-5 44 1.99E-4
9 SGTC_1370 2001-0092 3.49 44.6 µM 8.00E-5 54 2.45E-4
10 SGTC_610 4215-0184 3.41 155.0 µM 1.10E-4 exosome 26 3.22E-4
11 SGTC_2041 5107442 3.37 45.3 µM 1.30E-4 RSC complex & mRNA processing 45 3.72E-4
12 SGTC_1677 st019204 3.35 53.9 µM 1.41E-4 41 4.00E-4
13 SGTC_2295 7971645 3.21 200.0 µM 2.50E-4 50 6.55E-4
14 SGTC_386 1509-0011 3.06 3.1 µM 4.68E-4 193 0.00112
15 SGTC_1037 k284-1091 3.01 78.7 µM 5.62E-4 50 0.00132
16 SGTC_2320 7373003 2.98 200.0 µM 6.33E-4 65 0.00146
17 SGTC_2113 5491891 2.94 107.0 µM 7.22E-4 TSC3-RPN4 80 0.00164
18 SGTC_1176 0848-0131 2.91 83.3 µM 8.13E-4 Golgi 71 0.00181
19 SGTC_1979 st071809 2.89 45.3 µM 8.58E-4 RPP1 & pyrimidine depletion 59 0.00190
20 SGTC_412 gemfibrozil 2.86 100.0 µM 9.83E-4 DNA intercalators 30 0.00214

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.331 1.68E-86 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.315 4.45E-78 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.309 3.09E-75 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.308 8.16E-75 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.307 3.06E-74 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.298 6.75E-70 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.293 1.22E-67 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.290 4.39E-66 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.288 5.46E-65 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.277 3.79E-60 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.272 8.43E-58 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.268 3.39E-56 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.265 6.29E-55 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.265 6.59E-55 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.265 6.75E-55 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV