YOR296W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR296W / YOR296W

Click on Significant Values for Screen Details ID:SGTC_159|Compound:3970-0959|FD-Score:3.28|P-value:4.44E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:-2.67|P-value:6.98E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-2.76|P-value:4.84E-4 ID:SGTC_417|Compound:st075190|FD-Score:2.93|P-value:2.37E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:2.78|P-value:4.57E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.58|P-value:9.70E-6 ID:SGTC_855|Compound:0428-0020|FD-Score:3.50|P-value:1.48E-5 ID:SGTC_901|Compound:1112-0062|FD-Score:-2.75|P-value:5.00E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.66|P-value:6.06E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.74|P-value:3.75E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:2.72|P-value:5.74E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-2.77|P-value:4.64E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.26|P-value:4.97E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:2.75|P-value:5.23E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.28|P-value:4.61E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:2.92|P-value:2.51E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:2.71|P-value:6.07E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.30|P-value:4.03E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:-2.75|P-value:5.04E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.48|P-value:1.66E-5 ID:SGTC_1352|Compound:1496-0991|FD-Score:-2.97|P-value:1.90E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:2.61|P-value:9.07E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.66|P-value:5.79E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:2.86|P-value:3.16E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.51|P-value:1.42E-5 ID:SGTC_1602|Compound:st001878|FD-Score:-3.14|P-value:8.69E-5 ID:SGTC_1613|Compound:st002381|FD-Score:-3.37|P-value:2.82E-5 ID:SGTC_1622|Compound:st003707|FD-Score:3.70|P-value:4.91E-6 ID:SGTC_1794|Compound:st048918|FD-Score:2.77|P-value:4.80E-4 ID:SGTC_1855|Compound:st056195|FD-Score:2.75|P-value:5.05E-4 ID:SGTC_2097|Compound:5376186|FD-Score:-3.39|P-value:2.47E-5 ID:SGTC_2219|Compound:9098279|FD-Score:3.10|P-value:1.05E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-2.71|P-value:5.99E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:2.98|P-value:1.89E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:2.78|P-value:4.49E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.99|P-value:8.85E-7 ID:SGTC_2563|Compound:tomatine|FD-Score:4.19|P-value:2.82E-7 ID:SGTC_2568|Compound:diosmetin|FD-Score:-2.65|P-value:7.47E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.53|P-value:1.19E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.60|P-value:9.43E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.67|P-value:5.66E-6 ID:SGTC_2620|Compound:irigenin|FD-Score:3.40|P-value:2.41E-5 ID:SGTC_2623|Compound:humulene|FD-Score:-3.84|P-value:2.16E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:-4.50|P-value:3.58E-8 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.42|P-value:2.08E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:5.27|P-value:1.49E-10 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-2.88|P-value:2.87E-4 ID:SGTC_2837|Compound:9008476|FD-Score:4.27|P-value:1.69E-7 ID:SGTC_2858|Compound:9025781|FD-Score:2.60|P-value:9.76E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.51|P-value:1.33E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-2.80|P-value:4.06E-4 ID:SGTC_3177|Compound:9107506|FD-Score:2.90|P-value:2.68E-4 ID:SGTC_3251|Compound:9135047|FD-Score:-2.60|P-value:9.39E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-3.58|P-value:9.36E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:3.28|P-value:4.44E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:-2.67|P-value:6.98E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-2.76|P-value:4.84E-4 ID:SGTC_417|Compound:st075190|FD-Score:2.93|P-value:2.37E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:2.78|P-value:4.57E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.58|P-value:9.70E-6 ID:SGTC_855|Compound:0428-0020|FD-Score:3.50|P-value:1.48E-5 ID:SGTC_901|Compound:1112-0062|FD-Score:-2.75|P-value:5.00E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.66|P-value:6.06E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.74|P-value:3.75E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:2.72|P-value:5.74E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-2.77|P-value:4.64E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.26|P-value:4.97E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:2.75|P-value:5.23E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.28|P-value:4.61E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:2.92|P-value:2.51E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:2.71|P-value:6.07E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.30|P-value:4.03E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:-2.75|P-value:5.04E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.48|P-value:1.66E-5 ID:SGTC_1352|Compound:1496-0991|FD-Score:-2.97|P-value:1.90E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:2.61|P-value:9.07E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.66|P-value:5.79E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:2.86|P-value:3.16E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.51|P-value:1.42E-5 ID:SGTC_1602|Compound:st001878|FD-Score:-3.14|P-value:8.69E-5 ID:SGTC_1613|Compound:st002381|FD-Score:-3.37|P-value:2.82E-5 ID:SGTC_1622|Compound:st003707|FD-Score:3.70|P-value:4.91E-6 ID:SGTC_1794|Compound:st048918|FD-Score:2.77|P-value:4.80E-4 ID:SGTC_1855|Compound:st056195|FD-Score:2.75|P-value:5.05E-4 ID:SGTC_2097|Compound:5376186|FD-Score:-3.39|P-value:2.47E-5 ID:SGTC_2219|Compound:9098279|FD-Score:3.10|P-value:1.05E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-2.71|P-value:5.99E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:2.98|P-value:1.89E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:2.78|P-value:4.49E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.99|P-value:8.85E-7 ID:SGTC_2563|Compound:tomatine|FD-Score:4.19|P-value:2.82E-7 ID:SGTC_2568|Compound:diosmetin|FD-Score:-2.65|P-value:7.47E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.53|P-value:1.19E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.60|P-value:9.43E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.67|P-value:5.66E-6 ID:SGTC_2620|Compound:irigenin|FD-Score:3.40|P-value:2.41E-5 ID:SGTC_2623|Compound:humulene|FD-Score:-3.84|P-value:2.16E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:-4.50|P-value:3.58E-8 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.42|P-value:2.08E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:5.27|P-value:1.49E-10 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-2.88|P-value:2.87E-4 ID:SGTC_2837|Compound:9008476|FD-Score:4.27|P-value:1.69E-7 ID:SGTC_2858|Compound:9025781|FD-Score:2.60|P-value:9.76E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.51|P-value:1.33E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-2.80|P-value:4.06E-4 ID:SGTC_3177|Compound:9107506|FD-Score:2.90|P-value:2.68E-4 ID:SGTC_3251|Compound:9135047|FD-Score:-2.60|P-value:9.39E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-3.58|P-value:9.36E-6

Top fitness defect scores for YOR296W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2640 pentamidine 5.27 10.4 µM 1.49E-10 mitochondrial processes 10 6.67E-8
2 SGTC_2837 9008476 4.27 45.5 µM 1.69E-7 24 9.73E-6
3 SGTC_2563 tomatine 4.19 8.5 µM 2.82E-7 37 1.40E-5
4 SGTC_1622 st003707 3.70 19.4 µM 4.91E-6 calcium & mitochondrial duress 50 1.07E-4
5 SGTC_659 k018-0002 3.58 107.0 µM 9.70E-6 26 1.73E-4
6 SGTC_1571 st070080 3.51 73.4 µM 1.42E-5 29 2.28E-4
7 SGTC_855 0428-0020 3.50 25.0 µM 1.48E-5 Golgi 33 2.34E-4
8 SGTC_1345 1488-0192 3.48 31.4 µM 1.66E-5 25 2.55E-4
9 SGTC_2620 irigenin 3.40 100.0 µM 2.41E-5 59 3.33E-4
10 SGTC_1299 1079-1439 3.30 3.7 µM 4.03E-5 TSC3-RPN4 35 4.79E-4
11 SGTC_159 3970-0959 3.28 50.0 µM 4.44E-5 128 5.14E-4
12 SGTC_1222 0366-0074 3.28 1.2 µM 4.61E-5 TSC3-RPN4 39 5.28E-4
13 SGTC_1174 0739-0097 3.26 51.1 µM 4.97E-5 redox potentiating 58 5.57E-4
14 SGTC_2219 9098279 3.10 200.0 µM 1.05E-4 17 9.54E-4
15 SGTC_2519 cryptotanshinone 2.98 88.0 µM 1.89E-4 heme biosynthesis & mitochondrial translocase 44 0.00145
16 SGTC_417 st075190 2.93 100.0 µM 2.37E-4 56 0.00171
17 SGTC_1227 3909-8010 2.92 46.6 µM 2.51E-4 68 0.00178
18 SGTC_3177 9107506 2.90 49.5 µM 2.68E-4 ERG2 36 0.00187
19 SGTC_1568 digitonin 2.86 820.0 nM 3.16E-4 sphingolipid biosynthesis & PDR1 82 0.00210
20 SGTC_2533 agelasine 2.78 13.7 µM 4.49E-4 ERG2 117 0.00270

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 8.65E-14 YDR460W TFB3 het Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit
0.110 1.52E-10 YMR011W HXT2 hom High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
0.105 1.10E-9 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.103 2.05E-9 YBL064C PRX1 hom Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress
0.102 3.93E-9 YGR152C RSR1 hom GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
0.091 1.14E-7 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.091 1.50E-7 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.090 2.06E-7 YER044C-A MEI4 hom Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores
0.089 2.18E-7 YEL038W UTR4 hom Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus
0.088 3.15E-7 YER156C_p YER156C_p hom Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1
0.088 3.39E-7 YKL187C FAT3 hom Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.087 4.32E-7 YGR138C TPO2 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication
0.087 4.84E-7 YML109W ZDS2 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication
0.087 5.13E-7 YOR140W SFL1 hom Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
0.082 2.09E-6 YIR009W MSL1 hom U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members