YOR297C / TIM18

Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR297C / TIM18

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:2.82|P-value:5.17E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.21|P-value:9.54E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:6.78|P-value:1.50E-15 ID:SGTC_65|Compound:0798-0905|FD-Score:3.51|P-value:2.22E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:2.96|P-value:2.98E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:5.69|P-value:1.81E-11 ID:SGTC_201|Compound:4262-0159|FD-Score:3.62|P-value:1.29E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:-3.01|P-value:2.17E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.16|P-value:1.23E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:2.67|P-value:9.68E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.97|P-value:3.74E-9 ID:SGTC_320|Compound:4092-0846|FD-Score:2.69|P-value:8.95E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-2.66|P-value:9.52E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-4.70|P-value:2.02E-8 ID:SGTC_425|Compound:3825-7017|FD-Score:3.08|P-value:1.69E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:2.87|P-value:4.29E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.44|P-value:3.48E-14 ID:SGTC_528|Compound:3492-0019|FD-Score:3.84|P-value:4.03E-6 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.71|P-value:7.31E-6 ID:SGTC_634|Compound:1611-4317|FD-Score:3.19|P-value:1.04E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.19|P-value:9.83E-5 ID:SGTC_681|Compound:1642-0006|FD-Score:-2.74|P-value:6.76E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:4.14|P-value:7.51E-7 ID:SGTC_916|Compound:4466-0038|FD-Score:3.32|P-value:5.80E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:-2.86|P-value:4.22E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.13|P-value:1.26E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:2.69|P-value:8.86E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:6.08|P-value:7.60E-13 ID:SGTC_1320|Compound:1313-0481|FD-Score:2.66|P-value:9.91E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:2.94|P-value:3.17E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-2.72|P-value:7.42E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.67|P-value:3.58E-15 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.63|P-value:5.38E-15 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.81|P-value:4.40E-6 ID:SGTC_1724|Compound:st037281|FD-Score:2.71|P-value:8.29E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.21|P-value:9.71E-5 ID:SGTC_1730|Compound:st033808|FD-Score:-2.65|P-value:9.64E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-2.74|P-value:6.69E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.02|P-value:1.32E-6 ID:SGTC_1831|Compound:st055328|FD-Score:4.16|P-value:6.46E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.94|P-value:2.47E-12 ID:SGTC_1909|Compound:st060837|FD-Score:-2.91|P-value:3.32E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-2.95|P-value:2.89E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.71|P-value:8.18E-6 ID:SGTC_2034|Compound:5197015|FD-Score:2.75|P-value:7.08E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.21|P-value:9.37E-5 ID:SGTC_2335|Compound:9018011|FD-Score:2.90|P-value:3.71E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-4.76|P-value:1.33E-8 ID:SGTC_2430|Compound:5571206|FD-Score:3.72|P-value:7.83E-6 ID:SGTC_2483|Compound:5729050|FD-Score:2.98|P-value:2.70E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.21|P-value:9.67E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.74|P-value:6.85E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.36|P-value:4.34E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:7.08|P-value:8.78E-17 ID:SGTC_2619|Compound:obliquin|FD-Score:3.39|P-value:4.18E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:13.80|P-value:1.81E-58 ID:SGTC_2676|Compound:harmalol|FD-Score:2.88|P-value:4.07E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.01|P-value:2.91E-9 ID:SGTC_2848|Compound:9016370|FD-Score:3.06|P-value:1.88E-4 ID:SGTC_2921|Compound:7974240|FD-Score:2.66|P-value:9.92E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-2.73|P-value:7.08E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.37|P-value:4.21E-5 ID:SGTC_3157|Compound:9099274|FD-Score:2.78|P-value:6.30E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.07|P-value:1.66E-4 ID:SGTC_3237|Compound:9133362|FD-Score:2.97|P-value:2.79E-4 ID:SGTC_3311|Compound:9131146|FD-Score:6.43|P-value:3.51E-14 ID:SGTC_3317|Compound:9138495|FD-Score:-2.77|P-value:5.99E-4 ID:SGTC_3322|Compound:9139058|FD-Score:2.69|P-value:8.85E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.40|P-value:3.85E-5 ID:SGTC_3350|Compound:9150499|FD-Score:2.97|P-value:2.78E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:2.82|P-value:5.17E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.21|P-value:9.54E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:6.78|P-value:1.50E-15 ID:SGTC_65|Compound:0798-0905|FD-Score:3.51|P-value:2.22E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:2.96|P-value:2.98E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:5.69|P-value:1.81E-11 ID:SGTC_201|Compound:4262-0159|FD-Score:3.62|P-value:1.29E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:-3.01|P-value:2.17E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.16|P-value:1.23E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:2.67|P-value:9.68E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.97|P-value:3.74E-9 ID:SGTC_320|Compound:4092-0846|FD-Score:2.69|P-value:8.95E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-2.66|P-value:9.52E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-4.70|P-value:2.02E-8 ID:SGTC_425|Compound:3825-7017|FD-Score:3.08|P-value:1.69E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:2.87|P-value:4.29E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.44|P-value:3.48E-14 ID:SGTC_528|Compound:3492-0019|FD-Score:3.84|P-value:4.03E-6 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.71|P-value:7.31E-6 ID:SGTC_634|Compound:1611-4317|FD-Score:3.19|P-value:1.04E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.19|P-value:9.83E-5 ID:SGTC_681|Compound:1642-0006|FD-Score:-2.74|P-value:6.76E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:4.14|P-value:7.51E-7 ID:SGTC_916|Compound:4466-0038|FD-Score:3.32|P-value:5.80E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:-2.86|P-value:4.22E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.13|P-value:1.26E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:2.69|P-value:8.86E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:6.08|P-value:7.60E-13 ID:SGTC_1320|Compound:1313-0481|FD-Score:2.66|P-value:9.91E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:2.94|P-value:3.17E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-2.72|P-value:7.42E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.67|P-value:3.58E-15 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.63|P-value:5.38E-15 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.81|P-value:4.40E-6 ID:SGTC_1724|Compound:st037281|FD-Score:2.71|P-value:8.29E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.21|P-value:9.71E-5 ID:SGTC_1730|Compound:st033808|FD-Score:-2.65|P-value:9.64E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-2.74|P-value:6.69E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.02|P-value:1.32E-6 ID:SGTC_1831|Compound:st055328|FD-Score:4.16|P-value:6.46E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.94|P-value:2.47E-12 ID:SGTC_1909|Compound:st060837|FD-Score:-2.91|P-value:3.32E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-2.95|P-value:2.89E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.71|P-value:8.18E-6 ID:SGTC_2034|Compound:5197015|FD-Score:2.75|P-value:7.08E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.21|P-value:9.37E-5 ID:SGTC_2335|Compound:9018011|FD-Score:2.90|P-value:3.71E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-4.76|P-value:1.33E-8 ID:SGTC_2430|Compound:5571206|FD-Score:3.72|P-value:7.83E-6 ID:SGTC_2483|Compound:5729050|FD-Score:2.98|P-value:2.70E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.21|P-value:9.67E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.74|P-value:6.85E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.36|P-value:4.34E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:7.08|P-value:8.78E-17 ID:SGTC_2619|Compound:obliquin|FD-Score:3.39|P-value:4.18E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:13.80|P-value:1.81E-58 ID:SGTC_2676|Compound:harmalol|FD-Score:2.88|P-value:4.07E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.01|P-value:2.91E-9 ID:SGTC_2848|Compound:9016370|FD-Score:3.06|P-value:1.88E-4 ID:SGTC_2921|Compound:7974240|FD-Score:2.66|P-value:9.92E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-2.73|P-value:7.08E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.37|P-value:4.21E-5 ID:SGTC_3157|Compound:9099274|FD-Score:2.78|P-value:6.30E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.07|P-value:1.66E-4 ID:SGTC_3237|Compound:9133362|FD-Score:2.97|P-value:2.79E-4 ID:SGTC_3311|Compound:9131146|FD-Score:6.43|P-value:3.51E-14 ID:SGTC_3317|Compound:9138495|FD-Score:-2.77|P-value:5.99E-4 ID:SGTC_3322|Compound:9139058|FD-Score:2.69|P-value:8.85E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.40|P-value:3.85E-5 ID:SGTC_3350|Compound:9150499|FD-Score:2.97|P-value:2.78E-4

Top fitness defect scores for YOR297C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2651 1327-0036 13.80 5.0 µM 1.81E-58 9 1.14E-43
2 SGTC_2584 androsterone 7.08 48.7 µM 8.78E-17 cell wall 38 7.28E-13
3 SGTC_46 0329-0187a 6.78 2.2 µM 1.50E-15 20 5.95E-12
4 SGTC_514 4466-0038 6.44 2.6 nM 3.48E-14 cell wall 64 6.13E-11
5 SGTC_3311 9131146 6.43 2.9 µM 3.51E-14 cell wall 53 6.18E-11
6 SGTC_1226 3909-7979 6.08 35.4 µM 7.60E-13 13 6.06E-10
7 SGTC_1844 rapamycin 5.94 4.0 nM 2.47E-12 90 1.45E-9
8 SGTC_163 1327-0036 5.69 7.5 µM 1.81E-11 53 6.37E-9
9 SGTC_2679 rapamycin 5.01 1.0 nM 2.91E-9 96 2.79E-7
10 SGTC_312 4092-0653 4.97 6.8 µM 3.74E-9 ergosterol depletion effects on membrane 58 3.36E-7
11 SGTC_1831 st055328 4.16 12.0 µM 6.46E-7 heme biosynthesis & mitochondrial translocase 16 1.57E-5
12 SGTC_683 panaxydol 4.14 45.0 µM 7.51E-7 sphingolipid biosynthesis & PDR1 34 1.75E-5
13 SGTC_528 3492-0019 3.84 172.0 µM 4.03E-6 calcium & mitochondrial duress 232 6.16E-5
14 SGTC_2573 2',4'-dihydroxychalcone 3.74 15.0 µM 6.85E-6 60 9.17E-5
15 SGTC_2430 5571206 3.72 200.0 µM 7.83E-6 63 1.01E-4
16 SGTC_1941 st076221 3.71 61.8 µM 8.18E-6 sphingolipid biosynthesis & PDR1 89 1.05E-4
17 SGTC_201 4262-0159 3.62 12.8 µM 1.29E-5 ergosterol depletion effects on membrane 60 1.48E-4
18 SGTC_65 0798-0905 3.51 35.0 µM 2.22E-5 calcium & mitochondrial duress 114 2.21E-4
19 SGTC_3342 9147791 3.40 14.5 µM 3.85E-5 35 3.34E-4
20 SGTC_2619 obliquin 3.39 87.9 µM 4.18E-5 cell wall 185 3.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.420 1.31E-143 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.348 3.28E-96 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.335 9.59E-89 YNL239W LAP3 hom Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
0.334 5.03E-88 YPR120C CLB5 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
0.325 2.49E-83 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.311 2.54E-76 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.311 2.58E-76 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.299 4.12E-70 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.281 3.92E-62 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.280 1.99E-61 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.274 6.21E-59 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.270 4.65E-57 YMR070W MOT3 hom Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion
0.269 1.58E-56 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.266 2.45E-55 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.260 6.88E-53 YDL227C HO hom Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p