YOR300W_d

Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR300W / YOR300W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.95|P-value:1.91E-8 ID:SGTC_8|Compound:0354-0001|FD-Score:3.14|P-value:2.44E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:-2.80|P-value:8.41E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:4.90|P-value:2.60E-8 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.90|P-value:6.31E-6 ID:SGTC_757|Compound:1066-0008|FD-Score:3.26|P-value:1.53E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:2.87|P-value:7.34E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:2.87|P-value:7.41E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.27|P-value:1.29E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.47|P-value:5.11E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.03|P-value:3.47E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.52|P-value:4.12E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.10|P-value:2.28E-6 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.10|P-value:2.94E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:-2.91|P-value:5.62E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.18|P-value:2.10E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.75|P-value:1.40E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-6.28|P-value:1.13E-12 ID:SGTC_1944|Compound:st076371|FD-Score:2.93|P-value:5.71E-4 ID:SGTC_2107|Compound:5363541|FD-Score:4.30|P-value:8.86E-7 ID:SGTC_2116|Compound:5511452|FD-Score:3.65|P-value:2.55E-5 ID:SGTC_2124|Compound:5246320|FD-Score:5.26|P-value:2.57E-9 ID:SGTC_2329|Compound:6138490|FD-Score:-3.55|P-value:3.63E-5 ID:SGTC_2400|Compound:5203494|FD-Score:-3.27|P-value:1.27E-4 ID:SGTC_2415|Compound:st077333|FD-Score:2.94|P-value:5.56E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-3.94|P-value:5.18E-6 ID:SGTC_2487|Compound:5918373|FD-Score:2.88|P-value:7.06E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:6.12|P-value:4.99E-12 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.92|P-value:5.71E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-4.07|P-value:2.69E-6 ID:SGTC_2560|Compound:caryophyllene|FD-Score:2.93|P-value:5.89E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.35|P-value:9.97E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.89|P-value:7.70E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-11.10|P-value:9.71E-36 ID:SGTC_2619|Compound:obliquin|FD-Score:-2.83|P-value:7.76E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-2.84|P-value:7.43E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-4.00|P-value:3.85E-6 ID:SGTC_2692|Compound:st077426|FD-Score:3.40|P-value:8.06E-5 ID:SGTC_2808|Compound:7946468|FD-Score:-2.79|P-value:8.77E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.15|P-value:2.15E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.46|P-value:5.51E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-5.40|P-value:7.96E-10 ID:SGTC_2943|Compound:9068529|FD-Score:-2.90|P-value:5.90E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-2.77|P-value:9.63E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-4.04|P-value:3.19E-6 ID:SGTC_2987|Compound:9018338|FD-Score:-3.75|P-value:1.38E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-2.84|P-value:7.31E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.80|P-value:1.04E-5 ID:SGTC_3052|Compound:9092717|FD-Score:3.19|P-value:2.04E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.02|P-value:4.05E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.00|P-value:3.87E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.22|P-value:1.81E-4 ID:SGTC_3156|Compound:9099931|FD-Score:2.81|P-value:9.14E-4 ID:SGTC_3181|Compound:9108277|FD-Score:-2.91|P-value:5.63E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-2.94|P-value:5.06E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.95|P-value:1.91E-8 ID:SGTC_8|Compound:0354-0001|FD-Score:3.14|P-value:2.44E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:-2.80|P-value:8.41E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:4.90|P-value:2.60E-8 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.90|P-value:6.31E-6 ID:SGTC_757|Compound:1066-0008|FD-Score:3.26|P-value:1.53E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:2.87|P-value:7.34E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:2.87|P-value:7.41E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.27|P-value:1.29E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.47|P-value:5.11E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.03|P-value:3.47E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.52|P-value:4.12E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.10|P-value:2.28E-6 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.10|P-value:2.94E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:-2.91|P-value:5.62E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.18|P-value:2.10E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.75|P-value:1.40E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-6.28|P-value:1.13E-12 ID:SGTC_1944|Compound:st076371|FD-Score:2.93|P-value:5.71E-4 ID:SGTC_2107|Compound:5363541|FD-Score:4.30|P-value:8.86E-7 ID:SGTC_2116|Compound:5511452|FD-Score:3.65|P-value:2.55E-5 ID:SGTC_2124|Compound:5246320|FD-Score:5.26|P-value:2.57E-9 ID:SGTC_2329|Compound:6138490|FD-Score:-3.55|P-value:3.63E-5 ID:SGTC_2400|Compound:5203494|FD-Score:-3.27|P-value:1.27E-4 ID:SGTC_2415|Compound:st077333|FD-Score:2.94|P-value:5.56E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-3.94|P-value:5.18E-6 ID:SGTC_2487|Compound:5918373|FD-Score:2.88|P-value:7.06E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:6.12|P-value:4.99E-12 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.92|P-value:5.71E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-4.07|P-value:2.69E-6 ID:SGTC_2560|Compound:caryophyllene|FD-Score:2.93|P-value:5.89E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.35|P-value:9.97E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.89|P-value:7.70E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-11.10|P-value:9.71E-36 ID:SGTC_2619|Compound:obliquin|FD-Score:-2.83|P-value:7.76E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-2.84|P-value:7.43E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-4.00|P-value:3.85E-6 ID:SGTC_2692|Compound:st077426|FD-Score:3.40|P-value:8.06E-5 ID:SGTC_2808|Compound:7946468|FD-Score:-2.79|P-value:8.77E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.15|P-value:2.15E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.46|P-value:5.51E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-5.40|P-value:7.96E-10 ID:SGTC_2943|Compound:9068529|FD-Score:-2.90|P-value:5.90E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-2.77|P-value:9.63E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-4.04|P-value:3.19E-6 ID:SGTC_2987|Compound:9018338|FD-Score:-3.75|P-value:1.38E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-2.84|P-value:7.31E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.80|P-value:1.04E-5 ID:SGTC_3052|Compound:9092717|FD-Score:3.19|P-value:2.04E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.02|P-value:4.05E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.00|P-value:3.87E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.22|P-value:1.81E-4 ID:SGTC_3156|Compound:9099931|FD-Score:2.81|P-value:9.14E-4 ID:SGTC_3181|Compound:9108277|FD-Score:-2.91|P-value:5.63E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-2.94|P-value:5.06E-4

Top fitness defect scores for YOR300W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 6.12 3.7 µM 4.99E-12 11 4.55E-10
2 SGTC_2124 5246320 5.26 200.0 µM 2.57E-9 heme biosynthesis & mitochondrial translocase 6 7.25E-8
3 SGTC_6 0844-0013 4.95 19.8 µM 1.91E-8 38 3.70E-7
4 SGTC_130 0136-0219 4.90 337.7 µM 2.60E-8 11 4.75E-7
5 SGTC_2107 5363541 4.30 170.2 µM 8.86E-7 5 8.42E-6
6 SGTC_2569 tetrandrine 3.89 100.0 µM 7.70E-6 22 4.91E-5
7 SGTC_2116 5511452 3.65 16.9 µM 2.55E-5 20 1.31E-4
8 SGTC_2692 st077426 3.40 47.7 µM 8.06E-5 34 3.35E-4
9 SGTC_2568 diosmetin 3.35 100.0 µM 9.97E-5 43 3.99E-4
10 SGTC_757 1066-0008 3.26 322.0 µM 1.53E-4 Golgi 47 5.66E-4
11 SGTC_3108 9121785 3.22 49.5 µM 1.81E-4 40 6.50E-4
12 SGTC_3052 9092717 3.19 49.5 µM 2.04E-4 71 7.17E-4
13 SGTC_1282 0886-0010 3.18 32.4 µM 2.10E-4 endomembrane recycling 65 7.34E-4
14 SGTC_8 0354-0001 3.14 70.0 µM 2.44E-4 129 8.31E-4
15 SGTC_1270 0831-1170 3.10 17.3 µM 2.94E-4 40 9.67E-4
16 SGTC_3063 1327-0034 3.02 4.0 µM 4.05E-4 75 0.00126
17 SGTC_2415 st077333 2.94 57.7 µM 5.56E-4 120 0.00163
18 SGTC_1944 st076371 2.93 56.9 µM 5.71E-4 74 0.00167
19 SGTC_2560 caryophyllene 2.93 100.0 µM 5.89E-4 61 0.00171
20 SGTC_2487 5918373 2.88 44.0 µM 7.06E-4 67 0.00199

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.347 9.26E-96 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.301 3.77E-71 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.290 7.54E-66 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.285 7.61E-64 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.268 2.62E-56 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.259 9.64E-53 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.255 9.90E-51 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.237 3.01E-44 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.234 5.05E-43 YHR006W STP2 hom Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication
0.224 2.60E-39 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.208 3.27E-34 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.207 9.81E-34 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.206 2.18E-33 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.204 8.70E-33 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.204 1.01E-32 YJR098C_p YJR098C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies