YOR302W

CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR302W / YOR302W

Click on Significant Values for Screen Details ID:SGTC_163|Compound:1327-0036|FD-Score:3.58|P-value:4.15E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:4.46|P-value:4.61E-7 ID:SGTC_380|Compound:3970-0968|FD-Score:3.29|P-value:1.49E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.08|P-value:3.56E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.54|P-value:3.00E-7 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:-2.80|P-value:9.54E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.64|P-value:2.80E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-2.79|P-value:9.97E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.83|P-value:1.11E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.12|P-value:3.02E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:-3.08|P-value:3.25E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.01|P-value:4.71E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.26|P-value:1.54E-4 ID:SGTC_1743|Compound:st037606|FD-Score:2.93|P-value:6.55E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-2.92|P-value:6.17E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.13|P-value:2.82E-6 ID:SGTC_2107|Compound:5363541|FD-Score:2.91|P-value:6.83E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.06|P-value:3.58E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-2.94|P-value:5.70E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-2.85|P-value:8.12E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-3.94|P-value:6.46E-6 ID:SGTC_2309|Compound:7664088|FD-Score:3.14|P-value:2.84E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-2.93|P-value:5.88E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.16|P-value:2.32E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.37|P-value:1.08E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.19|P-value:2.02E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.16|P-value:2.38E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.12|P-value:3.06E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-2.81|P-value:9.28E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.11|P-value:3.14E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.93|P-value:6.70E-6 ID:SGTC_2839|Compound:9003951|FD-Score:3.59|P-value:3.90E-5 ID:SGTC_2846|Compound:9008642|FD-Score:3.39|P-value:9.70E-5 ID:SGTC_2852|Compound:9023854|FD-Score:-2.86|P-value:7.67E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.75|P-value:1.88E-5 ID:SGTC_2876|Compound:9059903|FD-Score:3.99|P-value:5.75E-6 ID:SGTC_2977|Compound:9011197|FD-Score:4.23|P-value:1.63E-6 ID:SGTC_2978|Compound:9011784|FD-Score:3.20|P-value:2.18E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.54|P-value:4.94E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-4.47|P-value:3.76E-7 ID:SGTC_3080|Compound:9117754|FD-Score:2.82|P-value:9.69E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-3.16|P-value:2.29E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.58|P-value:4.15E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:4.46|P-value:4.61E-7 ID:SGTC_380|Compound:3970-0968|FD-Score:3.29|P-value:1.49E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.08|P-value:3.56E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.54|P-value:3.00E-7 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:-2.80|P-value:9.54E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.64|P-value:2.80E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-2.79|P-value:9.97E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.83|P-value:1.11E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.12|P-value:3.02E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:-3.08|P-value:3.25E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.01|P-value:4.71E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.26|P-value:1.54E-4 ID:SGTC_1743|Compound:st037606|FD-Score:2.93|P-value:6.55E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-2.92|P-value:6.17E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.13|P-value:2.82E-6 ID:SGTC_2107|Compound:5363541|FD-Score:2.91|P-value:6.83E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.06|P-value:3.58E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-2.94|P-value:5.70E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-2.85|P-value:8.12E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-3.94|P-value:6.46E-6 ID:SGTC_2309|Compound:7664088|FD-Score:3.14|P-value:2.84E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-2.93|P-value:5.88E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.16|P-value:2.32E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.37|P-value:1.08E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.19|P-value:2.02E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.16|P-value:2.38E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.12|P-value:3.06E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-2.81|P-value:9.28E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.11|P-value:3.14E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.93|P-value:6.70E-6 ID:SGTC_2839|Compound:9003951|FD-Score:3.59|P-value:3.90E-5 ID:SGTC_2846|Compound:9008642|FD-Score:3.39|P-value:9.70E-5 ID:SGTC_2852|Compound:9023854|FD-Score:-2.86|P-value:7.67E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.75|P-value:1.88E-5 ID:SGTC_2876|Compound:9059903|FD-Score:3.99|P-value:5.75E-6 ID:SGTC_2977|Compound:9011197|FD-Score:4.23|P-value:1.63E-6 ID:SGTC_2978|Compound:9011784|FD-Score:3.20|P-value:2.18E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.54|P-value:4.94E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-4.47|P-value:3.76E-7 ID:SGTC_3080|Compound:9117754|FD-Score:2.82|P-value:9.69E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-3.16|P-value:2.29E-4

Top fitness defect scores for YOR302W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_473 2-arachidonoylglycerol 4.54 10.0 µM 3.00E-7 13 2.86E-6
2 SGTC_358 0075-0058 4.46 9.4 µM 4.61E-7 44 4.08E-6
3 SGTC_2977 9011197 4.23 71.4 µM 1.63E-6 14 1.17E-5
4 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 4.19 63.6 µM 2.02E-6 32 1.39E-5
5 SGTC_1779 st039427 4.13 55.0 µM 2.82E-6 22 1.84E-5
6 SGTC_2876 9059903 3.99 26.0 µM 5.75E-6 11 3.32E-5
7 SGTC_2870 9038528 3.75 13.0 µM 1.88E-5 21 8.91E-5
8 SGTC_2839 9003951 3.59 26.0 µM 3.90E-5 18 1.63E-4
9 SGTC_163 1327-0036 3.58 7.5 µM 4.15E-5 135 1.72E-4
10 SGTC_2989 9073649 3.54 71.4 µM 4.94E-5 57 1.99E-4
11 SGTC_2846 9008642 3.39 19.5 µM 9.70E-5 30 3.49E-4
12 SGTC_2516 gossypol 3.37 71.5 µM 1.08E-4 33 3.82E-4
13 SGTC_380 3970-0968 3.29 6.0 µM 1.49E-4 35 5.00E-4
14 SGTC_2978 9011784 3.20 43.0 µM 2.18E-4 67 6.87E-4
15 SGTC_2309 7664088 3.14 163.9 µM 2.84E-4 91 8.57E-4
16 SGTC_1395 3486-0190 3.12 4.3 µM 3.02E-4 50 9.00E-4
17 SGTC_2564 betulinic acid 3.12 100.0 µM 3.06E-4 68 9.10E-4
18 SGTC_2751 anetholtrithion 3.11 17.2 µM 3.14E-4 64 9.30E-4
19 SGTC_453 enantio-paf c16 3.08 10.0 µM 3.56E-4 234 0.00103
20 SGTC_1735 st034310 3.01 56.8 µM 4.71E-4 Golgi 68 0.00131

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.177 5.92E-25 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.162 3.27E-21 YOL071W EMI5 hom Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.161 8.00E-21 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.156 8.30E-20 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.145 3.31E-17 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.141 1.78E-16 YHL006C SHU1 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.139 7.60E-16 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.138 1.07E-15 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.136 2.66E-15 YMR150C IMP1 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.135 4.05E-15 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.134 5.56E-15 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.133 1.32E-14 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.130 5.10E-14 YDR110W FOB1 hom Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.129 5.85E-14 YJR130C STR2 hom Cystathionine gamma-synthase, converts cysteine into cystathionine
0.129 6.84E-14 YOL125W TRM13 hom 2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases