YOR309C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR309C / YOR309C

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:4.11|P-value:9.70E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:8.30|P-value:2.34E-14 ID:SGTC_148|Compound:3253-0744|FD-Score:4.18|P-value:7.32E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:9.91|P-value:1.07E-19 ID:SGTC_255|Compound:tunicamycin|FD-Score:-4.17|P-value:7.20E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.38|P-value:5.11E-7 ID:SGTC_276|Compound:colchicine|FD-Score:5.67|P-value:1.31E-7 ID:SGTC_277|Compound:nystatin|FD-Score:3.48|P-value:8.00E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:4.53|P-value:1.97E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:3.71|P-value:3.78E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.15|P-value:7.72E-5 ID:SGTC_584|Compound:0986-0246|FD-Score:3.43|P-value:9.23E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.50|P-value:7.51E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.68|P-value:1.08E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:3.89|P-value:2.08E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.52|P-value:1.61E-9 ID:SGTC_830|Compound:4076-0286|FD-Score:3.73|P-value:3.59E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.87|P-value:2.20E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.99|P-value:2.92E-6 ID:SGTC_891|Compound:0929-0073|FD-Score:4.51|P-value:2.13E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:-3.76|P-value:3.01E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.54|P-value:6.58E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.74|P-value:3.26E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.73|P-value:3.59E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:5.18|P-value:1.28E-6 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.42|P-value:8.95E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.82|P-value:6.15E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.85|P-value:4.82E-6 ID:SGTC_1722|Compound:st034304|FD-Score:4.01|P-value:1.39E-4 ID:SGTC_1837|Compound:st055472|FD-Score:-4.18|P-value:6.92E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.63|P-value:4.91E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-5.46|P-value:3.18E-7 ID:SGTC_2062|Compound:5245942|FD-Score:4.37|P-value:3.70E-5 ID:SGTC_2063|Compound:5246145|FD-Score:4.82|P-value:6.14E-6 ID:SGTC_2134|Compound:5324836|FD-Score:5.56|P-value:2.26E-7 ID:SGTC_2167|Compound:5876490|FD-Score:4.58|P-value:1.64E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.73|P-value:3.57E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.96|P-value:1.63E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-3.93|P-value:1.68E-4 ID:SGTC_2438|Compound:5259590|FD-Score:4.64|P-value:1.26E-5 ID:SGTC_2447|Compound:5741742|FD-Score:3.70|P-value:3.92E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.49|P-value:7.67E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.57|P-value:5.96E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.51|P-value:7.37E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.75|P-value:3.35E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-4.22|P-value:5.86E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-3.82|P-value:2.45E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.64|P-value:4.84E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-4.64|P-value:1.16E-5 ID:SGTC_2915|Compound:7971052|FD-Score:-3.72|P-value:3.48E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-5.10|P-value:1.70E-6 ID:SGTC_3037|Compound:9091026|FD-Score:-3.83|P-value:2.35E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.76|P-value:3.19E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-4.09|P-value:9.52E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-6.33|P-value:4.04E-9 ID:SGTC_3153|Compound:9100258|FD-Score:-4.34|P-value:3.78E-5 ID:SGTC_3178|Compound:9107506|FD-Score:3.48|P-value:8.12E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.75|P-value:7.45E-6 ID:SGTC_37|Compound:0566-0070|FD-Score:4.11|P-value:9.70E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:8.30|P-value:2.34E-14 ID:SGTC_148|Compound:3253-0744|FD-Score:4.18|P-value:7.32E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:9.91|P-value:1.07E-19 ID:SGTC_255|Compound:tunicamycin|FD-Score:-4.17|P-value:7.20E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.38|P-value:5.11E-7 ID:SGTC_276|Compound:colchicine|FD-Score:5.67|P-value:1.31E-7 ID:SGTC_277|Compound:nystatin|FD-Score:3.48|P-value:8.00E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:4.53|P-value:1.97E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:3.71|P-value:3.78E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.15|P-value:7.72E-5 ID:SGTC_584|Compound:0986-0246|FD-Score:3.43|P-value:9.23E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.50|P-value:7.51E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.68|P-value:1.08E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:3.89|P-value:2.08E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.52|P-value:1.61E-9 ID:SGTC_830|Compound:4076-0286|FD-Score:3.73|P-value:3.59E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.87|P-value:2.20E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.99|P-value:2.92E-6 ID:SGTC_891|Compound:0929-0073|FD-Score:4.51|P-value:2.13E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:-3.76|P-value:3.01E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.54|P-value:6.58E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.74|P-value:3.26E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.73|P-value:3.59E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:5.18|P-value:1.28E-6 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.42|P-value:8.95E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.82|P-value:6.15E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.85|P-value:4.82E-6 ID:SGTC_1722|Compound:st034304|FD-Score:4.01|P-value:1.39E-4 ID:SGTC_1837|Compound:st055472|FD-Score:-4.18|P-value:6.92E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.63|P-value:4.91E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-5.46|P-value:3.18E-7 ID:SGTC_2062|Compound:5245942|FD-Score:4.37|P-value:3.70E-5 ID:SGTC_2063|Compound:5246145|FD-Score:4.82|P-value:6.14E-6 ID:SGTC_2134|Compound:5324836|FD-Score:5.56|P-value:2.26E-7 ID:SGTC_2167|Compound:5876490|FD-Score:4.58|P-value:1.64E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.73|P-value:3.57E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.96|P-value:1.63E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-3.93|P-value:1.68E-4 ID:SGTC_2438|Compound:5259590|FD-Score:4.64|P-value:1.26E-5 ID:SGTC_2447|Compound:5741742|FD-Score:3.70|P-value:3.92E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.49|P-value:7.67E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.57|P-value:5.96E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.51|P-value:7.37E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.75|P-value:3.35E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-4.22|P-value:5.86E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-3.82|P-value:2.45E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.64|P-value:4.84E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-4.64|P-value:1.16E-5 ID:SGTC_2915|Compound:7971052|FD-Score:-3.72|P-value:3.48E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-5.10|P-value:1.70E-6 ID:SGTC_3037|Compound:9091026|FD-Score:-3.83|P-value:2.35E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.76|P-value:3.19E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-4.09|P-value:9.52E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-6.33|P-value:4.04E-9 ID:SGTC_3153|Compound:9100258|FD-Score:-4.34|P-value:3.78E-5 ID:SGTC_3178|Compound:9107506|FD-Score:3.48|P-value:8.12E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.75|P-value:7.45E-6

Top fitness defect scores for YOR309C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_177 1327-0068 9.91 8.4 µM 1.07E-19 6 1.86E-23
2 SGTC_118 0083-0097 8.30 135.3 µM 2.34E-14 translation 4 5.20E-17
3 SGTC_800 3448-7362 6.52 155.0 µM 1.61E-9 translation 34 3.54E-11
4 SGTC_276 colchicine 5.67 750.0 µM 1.31E-7 3 7.10E-9
5 SGTC_2134 5324836 5.56 1.5 µM 2.26E-7 4 1.37E-8
6 SGTC_273 hydroxyurea 5.38 18.1 mM 5.11E-7 heme biosynthesis & mitochondrial translocase 12 3.66E-8
7 SGTC_1183 1254-0324 5.18 198.0 µM 1.28E-6 4 1.10E-7
8 SGTC_832 4083-0019 4.99 164.0 µM 2.92E-6 translation 39 2.97E-7
9 SGTC_2063 5246145 4.82 200.0 µM 6.14E-6 13 7.28E-7
10 SGTC_1242 0402-0103 4.82 60.1 µM 6.15E-6 14 7.29E-7
11 SGTC_644 1498-1197 4.68 63.3 µM 1.08E-5 5 1.44E-6
12 SGTC_2438 5259590 4.64 200.0 µM 1.26E-5 10 1.72E-6
13 SGTC_2167 5876490 4.58 200.0 µM 1.64E-5 15 2.38E-6
14 SGTC_375 3970-0961 4.53 9.3 µM 1.97E-5 tubulin folding & SWR complex 10 2.96E-6
15 SGTC_891 0929-0073 4.51 133.0 µM 2.13E-5 12 3.24E-6
16 SGTC_2062 5245942 4.37 200.0 µM 3.70E-5 7 6.29E-6
17 SGTC_148 3253-0744 4.18 288.0 µM 7.32E-5 12 1.43E-5
18 SGTC_37 0566-0070 4.11 1.6 µM 9.70E-5 24 2.00E-5
19 SGTC_1722 st034304 4.01 3.6 µM 1.39E-4 mitochondrial processes 25 3.07E-5
20 SGTC_2323 6148992 3.96 148.3 µM 1.63E-4 33 3.74E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 4.30E-31 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.191 7.32E-29 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.177 5.95E-25 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.175 1.41E-24 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.175 2.50E-24 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.165 8.31E-22 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.165 8.24E-22 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.155 1.27E-19 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.153 4.62E-19 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.153 5.59E-19 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.149 3.82E-18 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.148 5.18E-18 YMR143W RPS16A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication
0.140 3.29E-16 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.136 2.21E-15 YLR264W RPS28B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication
0.135 3.55E-15 YPL193W RSA1 hom Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly