YOR311C / DGK1

Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR311C / DGK1

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.51|P-value:6.14E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:3.55|P-value:5.08E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:3.64|P-value:3.39E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:4.83|P-value:6.59E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:5.35|P-value:2.52E-9 ID:SGTC_271|Compound:rotenone|FD-Score:3.12|P-value:3.15E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.28|P-value:1.85E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.35|P-value:1.23E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:2.83|P-value:9.85E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:2.87|P-value:8.26E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.01|P-value:4.85E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:4.00|P-value:6.14E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:2.93|P-value:6.67E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:-2.96|P-value:6.59E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:2.91|P-value:7.19E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.05|P-value:4.18E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.63|P-value:3.58E-5 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.32|P-value:1.40E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.68|P-value:2.87E-5 ID:SGTC_1886|Compound:st057356|FD-Score:3.64|P-value:3.45E-5 ID:SGTC_1916|Compound:st067606|FD-Score:3.76|P-value:1.99E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.57|P-value:4.68E-5 ID:SGTC_2013|Compound:4024628|FD-Score:2.88|P-value:8.04E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.32|P-value:1.39E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-4.03|P-value:6.00E-6 ID:SGTC_2017|Compound:5132927|FD-Score:4.28|P-value:1.48E-6 ID:SGTC_2149|Compound:5554786|FD-Score:-3.18|P-value:2.74E-4 ID:SGTC_2153|Compound:5569715|FD-Score:-4.15|P-value:3.18E-6 ID:SGTC_2158|Compound:5657123|FD-Score:2.86|P-value:8.74E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.29|P-value:1.59E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.46|P-value:5.34E-7 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.59|P-value:4.28E-5 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.25|P-value:2.05E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-3.10|P-value:3.86E-4 ID:SGTC_3085|Compound:9117376|FD-Score:-2.99|P-value:5.83E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.62|P-value:4.13E-5 ID:SGTC_3322|Compound:9139058|FD-Score:3.94|P-value:8.19E-6 ID:SGTC_3354|Compound:9151612|FD-Score:2.96|P-value:6.00E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:3.51|P-value:6.14E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:3.55|P-value:5.08E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:3.64|P-value:3.39E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:4.83|P-value:6.59E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:5.35|P-value:2.52E-9 ID:SGTC_271|Compound:rotenone|FD-Score:3.12|P-value:3.15E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.28|P-value:1.85E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.35|P-value:1.23E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:2.83|P-value:9.85E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:2.87|P-value:8.26E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.01|P-value:4.85E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:4.00|P-value:6.14E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:2.93|P-value:6.67E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:-2.96|P-value:6.59E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:2.91|P-value:7.19E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.05|P-value:4.18E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.63|P-value:3.58E-5 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.32|P-value:1.40E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.68|P-value:2.87E-5 ID:SGTC_1886|Compound:st057356|FD-Score:3.64|P-value:3.45E-5 ID:SGTC_1916|Compound:st067606|FD-Score:3.76|P-value:1.99E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.57|P-value:4.68E-5 ID:SGTC_2013|Compound:4024628|FD-Score:2.88|P-value:8.04E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.32|P-value:1.39E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-4.03|P-value:6.00E-6 ID:SGTC_2017|Compound:5132927|FD-Score:4.28|P-value:1.48E-6 ID:SGTC_2149|Compound:5554786|FD-Score:-3.18|P-value:2.74E-4 ID:SGTC_2153|Compound:5569715|FD-Score:-4.15|P-value:3.18E-6 ID:SGTC_2158|Compound:5657123|FD-Score:2.86|P-value:8.74E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.29|P-value:1.59E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.46|P-value:5.34E-7 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.59|P-value:4.28E-5 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.25|P-value:2.05E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-3.10|P-value:3.86E-4 ID:SGTC_3085|Compound:9117376|FD-Score:-2.99|P-value:5.83E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.62|P-value:4.13E-5 ID:SGTC_3322|Compound:9139058|FD-Score:3.94|P-value:8.19E-6 ID:SGTC_3354|Compound:9151612|FD-Score:2.96|P-value:6.00E-4

Top fitness defect scores for YOR311C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_142 0335-0849 5.35 62.7 µM 2.52E-9 ubiquinone biosynthesis & proteasome 78 4.39E-8
2 SGTC_137 0438-0332 4.83 85.4 µM 6.59E-8 ubiquinone biosynthesis & proteasome 78 6.90E-7
3 SGTC_2401 5128683 4.46 200.0 µM 5.34E-7 26 4.04E-6
4 SGTC_2017 5132927 4.28 60.6 µM 1.48E-6 25 9.55E-6
5 SGTC_639 0833-0042 4.00 114.0 µM 6.14E-6 43 3.18E-5
6 SGTC_3322 9139058 3.94 2.1 µM 8.19E-6 cell wall 27 4.06E-5
7 SGTC_1916 st067606 3.76 49.2 µM 1.99E-5 46 8.60E-5
8 SGTC_1693 xanthone 3.68 101.9 µM 2.87E-5 DNA damage response 22 1.17E-4
9 SGTC_129 0088-0017 3.64 176.6 µM 3.39E-5 75 1.35E-4
10 SGTC_1886 st057356 3.64 49.9 µM 3.45E-5 60S ribosome export 26 1.37E-4
11 SGTC_1098 clofazimine 3.63 15.1 µM 3.58E-5 heme biosynthesis & mitochondrial translocase 37 1.42E-4
12 SGTC_2634 4'-methoxyflavone 3.59 100.0 µM 4.28E-5 43 1.64E-4
13 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.57 70.1 µM 4.68E-5 41 1.77E-4
14 SGTC_103 0844-0104 3.55 51.8 µM 5.08E-5 ERAD & cell cycle 165 1.90E-4
15 SGTC_17 0960-0276 3.51 49.8 µM 6.14E-5 57 2.24E-4
16 SGTC_402 epigallocatechin gallate 3.35 10.0 µM 1.23E-4 61 4.03E-4
17 SGTC_2014 4013930 3.32 200.0 µM 1.39E-4 66 4.45E-4
18 SGTC_1301 naphtanilide LB 3.32 4.8 µM 1.40E-4 heme requiring 23 4.50E-4
19 SGTC_2335 9018011 3.29 154.2 µM 1.59E-4 49 5.00E-4
20 SGTC_271 rotenone 3.12 740.0 µM 3.15E-4 65 8.93E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.233 1.35E-42 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.194 6.84E-30 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.192 3.22E-29 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.170 5.02E-23 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.164 9.98E-22 YOR165W SEY1 hom Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
0.161 7.14E-21 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.156 9.56E-20 YGL121C GPG1 hom Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing
0.156 1.07E-19 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.152 7.22E-19 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.152 8.33E-19 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.151 1.41E-18 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.150 2.94E-18 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.146 1.98E-17 YIL090W ICE2 hom Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
0.145 2.94E-17 YLR379W_d YLR379W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C
0.142 1.34E-16 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data