YOR312C / RPL20B

Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR312C / RPL20B

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:-3.32|P-value:8.52E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.20|P-value:5.25E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.74|P-value:7.07E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.81|P-value:1.46E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:-3.42|P-value:5.96E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:5.62|P-value:7.45E-9 ID:SGTC_118|Compound:0083-0097|FD-Score:6.13|P-value:3.66E-10 ID:SGTC_146|Compound:3448-8650|FD-Score:3.54|P-value:1.53E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:4.36|P-value:5.09E-6 ID:SGTC_255|Compound:tunicamycin|FD-Score:-5.32|P-value:1.63E-7 ID:SGTC_258|Compound:haloperidol|FD-Score:3.01|P-value:9.92E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.36|P-value:7.46E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:4.82|P-value:5.68E-7 ID:SGTC_343|Compound:4130-2827|FD-Score:3.23|P-value:4.66E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.64|P-value:1.03E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.52|P-value:1.63E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.34|P-value:7.80E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:-3.63|P-value:2.82E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-7.33|P-value:6.68E-13 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.26|P-value:4.33E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.11|P-value:7.12E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:-3.46|P-value:5.30E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:3.18|P-value:5.65E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:6.00|P-value:8.35E-10 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.51|P-value:4.44E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.48|P-value:1.88E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.63|P-value:1.09E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.07|P-value:8.12E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.10|P-value:1.57E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.49|P-value:1.82E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:-4.11|P-value:4.51E-5 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.19|P-value:5.50E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.13|P-value:6.69E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-4.05|P-value:5.76E-5 ID:SGTC_1673|Compound:st016611|FD-Score:-3.49|P-value:4.75E-4 ID:SGTC_1683|Compound:st010134|FD-Score:5.73|P-value:4.03E-9 ID:SGTC_1707|Compound:st032323|FD-Score:-4.06|P-value:5.41E-5 ID:SGTC_1712|Compound:st032288|FD-Score:9.67|P-value:2.55E-22 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.11|P-value:4.54E-5 ID:SGTC_1731|Compound:st035964|FD-Score:-3.87|P-value:1.17E-4 ID:SGTC_1813|Compound:st051246|FD-Score:-3.43|P-value:5.89E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-4.35|P-value:1.66E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-3.66|P-value:2.57E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.05|P-value:8.73E-4 ID:SGTC_1923|Compound:st058458|FD-Score:4.38|P-value:4.61E-6 ID:SGTC_1925|Compound:st057770|FD-Score:-4.11|P-value:4.38E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.03|P-value:9.24E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.25|P-value:4.49E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.52|P-value:1.63E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-5.08|P-value:5.52E-7 ID:SGTC_2308|Compound:7584454|FD-Score:-3.45|P-value:5.50E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.13|P-value:6.60E-4 ID:SGTC_2339|Compound:9000433|FD-Score:4.41|P-value:3.96E-6 ID:SGTC_2400|Compound:5203494|FD-Score:3.56|P-value:1.40E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.12|P-value:6.99E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.55|P-value:1.17E-8 ID:SGTC_2809|Compound:7964133|FD-Score:3.43|P-value:2.34E-4 ID:SGTC_2972|Compound:9093619|FD-Score:4.81|P-value:5.81E-7 ID:SGTC_3000|Compound:9075062|FD-Score:-4.07|P-value:5.32E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-3.74|P-value:1.92E-4 ID:SGTC_3169|Compound:9102970|FD-Score:3.96|P-value:2.85E-5 ID:SGTC_3173|Compound:9105693|FD-Score:3.60|P-value:1.23E-4 ID:SGTC_3174|Compound:9107204|FD-Score:-3.53|P-value:4.04E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.26|P-value:4.33E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-5.36|P-value:1.34E-7 ID:SGTC_4|Compound:0960-0234|FD-Score:-3.32|P-value:8.52E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.20|P-value:5.25E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.74|P-value:7.07E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.81|P-value:1.46E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:-3.42|P-value:5.96E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:5.62|P-value:7.45E-9 ID:SGTC_118|Compound:0083-0097|FD-Score:6.13|P-value:3.66E-10 ID:SGTC_146|Compound:3448-8650|FD-Score:3.54|P-value:1.53E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:4.36|P-value:5.09E-6 ID:SGTC_255|Compound:tunicamycin|FD-Score:-5.32|P-value:1.63E-7 ID:SGTC_258|Compound:haloperidol|FD-Score:3.01|P-value:9.92E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.36|P-value:7.46E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:4.82|P-value:5.68E-7 ID:SGTC_343|Compound:4130-2827|FD-Score:3.23|P-value:4.66E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.64|P-value:1.03E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.52|P-value:1.63E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.34|P-value:7.80E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:-3.63|P-value:2.82E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-7.33|P-value:6.68E-13 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.26|P-value:4.33E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.11|P-value:7.12E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:-3.46|P-value:5.30E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:3.18|P-value:5.65E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:6.00|P-value:8.35E-10 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.51|P-value:4.44E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.48|P-value:1.88E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.63|P-value:1.09E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.07|P-value:8.12E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.10|P-value:1.57E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.49|P-value:1.82E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:-4.11|P-value:4.51E-5 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.19|P-value:5.50E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.13|P-value:6.69E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-4.05|P-value:5.76E-5 ID:SGTC_1673|Compound:st016611|FD-Score:-3.49|P-value:4.75E-4 ID:SGTC_1683|Compound:st010134|FD-Score:5.73|P-value:4.03E-9 ID:SGTC_1707|Compound:st032323|FD-Score:-4.06|P-value:5.41E-5 ID:SGTC_1712|Compound:st032288|FD-Score:9.67|P-value:2.55E-22 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.11|P-value:4.54E-5 ID:SGTC_1731|Compound:st035964|FD-Score:-3.87|P-value:1.17E-4 ID:SGTC_1813|Compound:st051246|FD-Score:-3.43|P-value:5.89E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-4.35|P-value:1.66E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-3.66|P-value:2.57E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.05|P-value:8.73E-4 ID:SGTC_1923|Compound:st058458|FD-Score:4.38|P-value:4.61E-6 ID:SGTC_1925|Compound:st057770|FD-Score:-4.11|P-value:4.38E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.03|P-value:9.24E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.25|P-value:4.49E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.52|P-value:1.63E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-5.08|P-value:5.52E-7 ID:SGTC_2308|Compound:7584454|FD-Score:-3.45|P-value:5.50E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.13|P-value:6.60E-4 ID:SGTC_2339|Compound:9000433|FD-Score:4.41|P-value:3.96E-6 ID:SGTC_2400|Compound:5203494|FD-Score:3.56|P-value:1.40E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.12|P-value:6.99E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.55|P-value:1.17E-8 ID:SGTC_2809|Compound:7964133|FD-Score:3.43|P-value:2.34E-4 ID:SGTC_2972|Compound:9093619|FD-Score:4.81|P-value:5.81E-7 ID:SGTC_3000|Compound:9075062|FD-Score:-4.07|P-value:5.32E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-3.74|P-value:1.92E-4 ID:SGTC_3169|Compound:9102970|FD-Score:3.96|P-value:2.85E-5 ID:SGTC_3173|Compound:9105693|FD-Score:3.60|P-value:1.23E-4 ID:SGTC_3174|Compound:9107204|FD-Score:-3.53|P-value:4.04E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.26|P-value:4.33E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-5.36|P-value:1.34E-7

Top fitness defect scores for YOR312C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1712 st032288 9.67 53.4 µM 2.55E-22 calcium & mitochondrial duress 27 1.97E-22
2 SGTC_118 0083-0097 6.13 135.3 µM 3.66E-10 translation 21 4.41E-10
3 SGTC_856 0433-0016 6.00 11.3 µM 8.35E-10 1 1.02E-9
4 SGTC_1683 st010134 5.73 710.0 nM 4.03E-9 5 4.99E-9
5 SGTC_117 lucigenin 5.62 22.1 µM 7.45E-9 redox potentiating 44 9.28E-9
6 SGTC_2688 kanamycin b 5.55 96.7 µM 1.17E-8 calcium & mitochondrial duress 192 1.47E-8
7 SGTC_309 k408-0051 4.82 1.5 µM 5.68E-7 32 7.32E-7
8 SGTC_2972 9093619 4.81 59.9 µM 5.81E-7 9 7.50E-7
9 SGTC_2339 9000433 4.41 200.0 µM 3.96E-6 23 5.16E-6
10 SGTC_1923 st058458 4.38 19.1 µM 4.61E-6 23 6.01E-6
11 SGTC_187 1488-2104 4.36 32.7 µM 5.09E-6 calcium & mitochondrial duress 29 6.64E-6
12 SGTC_1367 1812-0510 4.10 76.9 µM 1.57E-5 17 2.06E-5
13 SGTC_3169 9102970 3.96 49.5 µM 2.85E-5 RPP1 & pyrimidine depletion 2 3.74E-5
14 SGTC_40 0327-0103 3.74 19.8 µM 7.07E-5 38 9.28E-5
15 SGTC_449 xestospongin c 3.64 11.2 µM 1.03E-4 NEO1-PIK1 84 1.35E-4
16 SGTC_1225 1216-0074 3.63 20.6 µM 1.09E-4 33 1.43E-4
17 SGTC_3173 9105693 3.60 49.5 µM 1.23E-4 35 1.61E-4
18 SGTC_2400 5203494 3.56 178.7 µM 1.40E-4 RSC complex & mRNA processing 33 1.83E-4
19 SGTC_146 3448-8650 3.54 53.1 µM 1.53E-4 NEO1-PIK1 171 2.01E-4
20 SGTC_451 chloral hydrate 3.52 100.0 µM 1.63E-4 74 2.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 8.57E-31 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.182 2.73E-26 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.180 8.14E-26 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.178 2.05E-25 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.178 2.36E-25 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.177 4.85E-25 YHR064C SSZ1 hom Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
0.172 1.35E-23 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.171 1.65E-23 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.162 3.30E-21 YDR443C SSN2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation
0.159 1.76E-20 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.153 4.85E-19 YNL288W CAF40 hom Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
0.152 1.01E-18 YNL246W VPS75 hom NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress
0.149 4.14E-18 YIL035C CKA1 hom Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching
0.149 4.52E-18 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.149 4.56E-18 YGL151W NUT1 hom Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription