HIPHOP chemogenomics database

YOR324C / FRT1

Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YOR324C / FRT1

Click on Significant Values for Screen Details

Top fitness defect scores for YOR324C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1086	cerivastatin	4.89	2.2 µM	1.67E-6	azole & statin	5	5.17E-7
2	SGTC_367	0335-0881	4.72	7.1 µM	3.54E-6	ubiquinone biosynthesis & proteasome	50	1.18E-6
3	SGTC_2127	5253358	4.62	187.9 µM	5.59E-6		13	1.95E-6
4	SGTC_568	1193-0097	4.43	7.5 µM	1.24E-5	ERAD & cell cycle	115	4.71E-6
5	SGTC_561	1550-0330	4.30	72.9 µM	2.17E-5		7	8.71E-6
6	SGTC_2667	digitoxin	4.28	100.0 µM	2.28E-5		1	9.22E-6
7	SGTC_1612	st002233	4.26	45.4 µM	2.46E-5		11	1.00E-5
8	SGTC_2685	mycophenolic acid	4.20	18.9 µM	3.20E-5	RNA pol III & RNase P/MRP	3	1.34E-5
9	SGTC_61	0978-8327	4.17	98.6 µM	3.55E-5	ergosterol biosynthesis	27	1.50E-5
10	SGTC_361	000s-0510	4.16	1.4 µM	3.79E-5		28	1.61E-5
11	SGTC_2432	5630864	4.04	12.2 µM	6.10E-5		19	2.72E-5
12	SGTC_2658	polymyxin b sulfate	4.01	77.0 µM	6.77E-5	NEO1	38	3.05E-5
13	SGTC_1619	st003326	3.97	88.7 µM	7.86E-5	60S ribosome export	18	3.60E-5
14	SGTC_1167	k781-0610	3.88	148.0 µM	1.11E-4	RNA processing & uracil transport	28	5.26E-5
15	SGTC_3314	9135860	3.78	59.4 µM	1.57E-4		23	7.69E-5
16	SGTC_2663	amphotericin b	3.73	100.0 µM	1.93E-4		13	9.69E-5
17	SGTC_2184	6075246	3.72	200.0 µM	1.96E-4		32	9.85E-5
18	SGTC_1610	st001799	3.71	48.1 µM	2.03E-4		16	1.03E-4
19	SGTC_2642	cholecalciferol	3.69	100.0 µM	2.18E-4		23	1.11E-4
20	SGTC_1188	1403-0014	3.68	4.6 µM	2.30E-4	mitochondrial stress	64	1.18E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.113	5.06E-11	YPL077C_p	YPL077C_p	hom	Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.113	5.12E-11	YPR153W	YPR153W	hom	Putative protein of unknown function
0.113	5.19E-11	YER085C_p	YER085C_p	hom	Putative protein of unknown function
0.110	1.50E-10	YBR248C	HIS7	hom	Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor
0.101	4.71E-9	YBR255W	MTC4	hom	Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1
0.095	3.46E-8	YGR041W	BUD9	hom	Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole
0.095	3.96E-8	YMR126C_p	DLT1_p	hom	Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.094	4.61E-8	YDL001W	RMD1	hom	Cytoplasmic protein required for sporulation
0.093	7.40E-8	YDR500C	RPL37B	hom	Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication
0.089	2.57E-7	YAL044W-A_p	YAL044W-A_p	hom	Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein
0.086	6.94E-7	YOL028C	YAP7	hom	Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
0.085	9.06E-7	YIL117C	PRM5	hom	Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling
0.084	9.68E-7	YKL098W	MTC2	hom	Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.082	2.21E-6	YBR197C	YBR197C	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication
0.080	3.17E-6	YKR065C	PAM17	hom	Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress