YOR324C / FRT1

Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR324C / FRT1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.63|P-value:2.76E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:4.17|P-value:3.55E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:3.55|P-value:3.64E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.44|P-value:5.25E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:4.16|P-value:3.79E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:4.72|P-value:3.54E-6 ID:SGTC_406|Compound:estrone|FD-Score:-4.24|P-value:3.00E-5 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-4.02|P-value:7.17E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:4.30|P-value:2.17E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.43|P-value:1.24E-5 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.40|P-value:6.56E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.26|P-value:9.62E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-4.36|P-value:1.85E-5 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.60|P-value:3.08E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:4.89|P-value:1.67E-6 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.88|P-value:1.11E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.68|P-value:2.30E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.40|P-value:5.94E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.71|P-value:2.03E-4 ID:SGTC_1612|Compound:st002233|FD-Score:4.26|P-value:2.46E-5 ID:SGTC_1619|Compound:st003326|FD-Score:3.97|P-value:7.86E-5 ID:SGTC_1741|Compound:st038134|FD-Score:-3.32|P-value:8.46E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.53|P-value:3.86E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.62|P-value:2.88E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.62|P-value:5.59E-6 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.48|P-value:4.54E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.72|P-value:1.96E-4 ID:SGTC_2432|Compound:5630864|FD-Score:4.04|P-value:6.10E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.17|P-value:3.95E-5 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.69|P-value:2.18E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.01|P-value:6.77E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.73|P-value:1.93E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:4.28|P-value:2.28E-5 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:4.20|P-value:3.20E-5 ID:SGTC_2883|Compound:9059145|FD-Score:-4.05|P-value:6.34E-5 ID:SGTC_3192|Compound:9110362|FD-Score:-3.99|P-value:8.12E-5 ID:SGTC_3196|Compound:9111891|FD-Score:-4.14|P-value:4.57E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.66|P-value:2.49E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.78|P-value:1.57E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.63|P-value:2.76E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:4.17|P-value:3.55E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:3.55|P-value:3.64E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.44|P-value:5.25E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:4.16|P-value:3.79E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:4.72|P-value:3.54E-6 ID:SGTC_406|Compound:estrone|FD-Score:-4.24|P-value:3.00E-5 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-4.02|P-value:7.17E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:4.30|P-value:2.17E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.43|P-value:1.24E-5 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.40|P-value:6.56E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.26|P-value:9.62E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-4.36|P-value:1.85E-5 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.60|P-value:3.08E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:4.89|P-value:1.67E-6 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.88|P-value:1.11E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.68|P-value:2.30E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.40|P-value:5.94E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.71|P-value:2.03E-4 ID:SGTC_1612|Compound:st002233|FD-Score:4.26|P-value:2.46E-5 ID:SGTC_1619|Compound:st003326|FD-Score:3.97|P-value:7.86E-5 ID:SGTC_1741|Compound:st038134|FD-Score:-3.32|P-value:8.46E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.53|P-value:3.86E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.62|P-value:2.88E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.62|P-value:5.59E-6 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.48|P-value:4.54E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.72|P-value:1.96E-4 ID:SGTC_2432|Compound:5630864|FD-Score:4.04|P-value:6.10E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.17|P-value:3.95E-5 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.69|P-value:2.18E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.01|P-value:6.77E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.73|P-value:1.93E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:4.28|P-value:2.28E-5 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:4.20|P-value:3.20E-5 ID:SGTC_2883|Compound:9059145|FD-Score:-4.05|P-value:6.34E-5 ID:SGTC_3192|Compound:9110362|FD-Score:-3.99|P-value:8.12E-5 ID:SGTC_3196|Compound:9111891|FD-Score:-4.14|P-value:4.57E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.66|P-value:2.49E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.78|P-value:1.57E-4

Top fitness defect scores for YOR324C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1086 cerivastatin 4.89 2.2 µM 1.67E-6 azole & statin 5 5.17E-7
2 SGTC_367 0335-0881 4.72 7.1 µM 3.54E-6 ubiquinone biosynthesis & proteasome 50 1.18E-6
3 SGTC_2127 5253358 4.62 187.9 µM 5.59E-6 13 1.95E-6
4 SGTC_568 1193-0097 4.43 7.5 µM 1.24E-5 ERAD & cell cycle 115 4.71E-6
5 SGTC_561 1550-0330 4.30 72.9 µM 2.17E-5 7 8.71E-6
6 SGTC_2667 digitoxin 4.28 100.0 µM 2.28E-5 1 9.22E-6
7 SGTC_1612 st002233 4.26 45.4 µM 2.46E-5 11 1.00E-5
8 SGTC_2685 mycophenolic acid 4.20 18.9 µM 3.20E-5 RNA pol III & RNase P/MRP 3 1.34E-5
9 SGTC_61 0978-8327 4.17 98.6 µM 3.55E-5 ergosterol biosynthesis 27 1.50E-5
10 SGTC_361 000s-0510 4.16 1.4 µM 3.79E-5 28 1.61E-5
11 SGTC_2432 5630864 4.04 12.2 µM 6.10E-5 19 2.72E-5
12 SGTC_2658 polymyxin b sulfate 4.01 77.0 µM 6.77E-5 NEO1 38 3.05E-5
13 SGTC_1619 st003326 3.97 88.7 µM 7.86E-5 60S ribosome export 18 3.60E-5
14 SGTC_1167 k781-0610 3.88 148.0 µM 1.11E-4 RNA processing & uracil transport 28 5.26E-5
15 SGTC_3314 9135860 3.78 59.4 µM 1.57E-4 23 7.69E-5
16 SGTC_2663 amphotericin b 3.73 100.0 µM 1.93E-4 13 9.69E-5
17 SGTC_2184 6075246 3.72 200.0 µM 1.96E-4 32 9.85E-5
18 SGTC_1610 st001799 3.71 48.1 µM 2.03E-4 16 1.03E-4
19 SGTC_2642 cholecalciferol 3.69 100.0 µM 2.18E-4 23 1.11E-4
20 SGTC_1188 1403-0014 3.68 4.6 µM 2.30E-4 mitochondrial stress 64 1.18E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 5.06E-11 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.113 5.12E-11 YPR153W YPR153W hom Putative protein of unknown function
0.113 5.19E-11 YER085C_p YER085C_p hom Putative protein of unknown function
0.110 1.50E-10 YBR248C HIS7 hom Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor
0.101 4.71E-9 YBR255W MTC4 hom Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1
0.095 3.46E-8 YGR041W BUD9 hom Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole
0.095 3.96E-8 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.094 4.61E-8 YDL001W RMD1 hom Cytoplasmic protein required for sporulation
0.093 7.40E-8 YDR500C RPL37B hom Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication
0.089 2.57E-7 YAL044W-A_p YAL044W-A_p hom Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein
0.086 6.94E-7 YOL028C YAP7 hom Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
0.085 9.06E-7 YIL117C PRM5 hom Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling
0.084 9.68E-7 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.082 2.21E-6 YBR197C YBR197C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication
0.080 3.17E-6 YKR065C PAM17 hom Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress