YOR334W / MRS2

Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR334W / MRS2

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:-3.18|P-value:4.47E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-8.80|P-value:1.55E-20 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.53|P-value:1.10E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:6.42|P-value:7.87E-12 ID:SGTC_236|Compound:1509-0011|FD-Score:4.57|P-value:7.85E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:4.35|P-value:2.42E-6 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.52|P-value:1.16E-4 ID:SGTC_484|Compound:loperamide|FD-Score:3.45|P-value:1.44E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.63|P-value:6.93E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:3.89|P-value:2.15E-5 ID:SGTC_680|Compound:0417-1641|FD-Score:3.67|P-value:5.88E-5 ID:SGTC_726|Compound:3448-4391|FD-Score:3.22|P-value:3.57E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.04|P-value:7.00E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.87|P-value:2.42E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.13|P-value:4.99E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.36|P-value:2.05E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:-3.16|P-value:4.68E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:4.18|P-value:5.69E-6 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.03|P-value:1.14E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.86|P-value:3.92E-10 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.33|P-value:2.36E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.57|P-value:7.92E-7 ID:SGTC_1465|Compound:k213-0056|FD-Score:-4.50|P-value:1.21E-6 ID:SGTC_1470|Compound:k295-0292|FD-Score:-3.01|P-value:8.34E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:-3.27|P-value:3.17E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.77|P-value:3.78E-5 ID:SGTC_1901|Compound:st060216|FD-Score:-3.09|P-value:6.26E-4 ID:SGTC_2035|Compound:5154463|FD-Score:2.94|P-value:9.94E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.59|P-value:8.13E-5 ID:SGTC_2105|Compound:5350118|FD-Score:3.01|P-value:7.80E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-3.41|P-value:1.82E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.92|P-value:1.95E-5 ID:SGTC_2329|Compound:6138490|FD-Score:-4.14|P-value:7.33E-6 ID:SGTC_2332|Compound:7982454|FD-Score:4.08|P-value:9.21E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-4.40|P-value:2.09E-6 ID:SGTC_2549|Compound:cedrol|FD-Score:3.27|P-value:2.98E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.42|P-value:1.68E-6 ID:SGTC_2683|Compound:piperine|FD-Score:3.02|P-value:7.55E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:4.45|P-value:1.47E-6 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.45|P-value:1.45E-6 ID:SGTC_2816|Compound:7982706|FD-Score:-3.24|P-value:3.55E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-4.13|P-value:7.69E-6 ID:SGTC_2825|Compound:7998094|FD-Score:-3.30|P-value:2.80E-4 ID:SGTC_2841|Compound:9004761|FD-Score:2.96|P-value:9.21E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-3.80|P-value:3.55E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-4.51|P-value:1.20E-6 ID:SGTC_3138|Compound:9097216|FD-Score:-3.46|P-value:1.46E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-3.96|P-value:1.73E-5 ID:SGTC_3151|Compound:9099821|FD-Score:-3.03|P-value:7.55E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-3.05|P-value:7.23E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.91|P-value:1.99E-5 ID:SGTC_3328|Compound:9140624|FD-Score:4.11|P-value:7.88E-6 ID:SGTC_4|Compound:0960-0234|FD-Score:-3.18|P-value:4.47E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-8.80|P-value:1.55E-20 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.53|P-value:1.10E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:6.42|P-value:7.87E-12 ID:SGTC_236|Compound:1509-0011|FD-Score:4.57|P-value:7.85E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:4.35|P-value:2.42E-6 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.52|P-value:1.16E-4 ID:SGTC_484|Compound:loperamide|FD-Score:3.45|P-value:1.44E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.63|P-value:6.93E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:3.89|P-value:2.15E-5 ID:SGTC_680|Compound:0417-1641|FD-Score:3.67|P-value:5.88E-5 ID:SGTC_726|Compound:3448-4391|FD-Score:3.22|P-value:3.57E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.04|P-value:7.00E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.87|P-value:2.42E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.13|P-value:4.99E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.36|P-value:2.05E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:-3.16|P-value:4.68E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:4.18|P-value:5.69E-6 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.03|P-value:1.14E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.86|P-value:3.92E-10 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.33|P-value:2.36E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.57|P-value:7.92E-7 ID:SGTC_1465|Compound:k213-0056|FD-Score:-4.50|P-value:1.21E-6 ID:SGTC_1470|Compound:k295-0292|FD-Score:-3.01|P-value:8.34E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:-3.27|P-value:3.17E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.77|P-value:3.78E-5 ID:SGTC_1901|Compound:st060216|FD-Score:-3.09|P-value:6.26E-4 ID:SGTC_2035|Compound:5154463|FD-Score:2.94|P-value:9.94E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.59|P-value:8.13E-5 ID:SGTC_2105|Compound:5350118|FD-Score:3.01|P-value:7.80E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-3.41|P-value:1.82E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.92|P-value:1.95E-5 ID:SGTC_2329|Compound:6138490|FD-Score:-4.14|P-value:7.33E-6 ID:SGTC_2332|Compound:7982454|FD-Score:4.08|P-value:9.21E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-4.40|P-value:2.09E-6 ID:SGTC_2549|Compound:cedrol|FD-Score:3.27|P-value:2.98E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.42|P-value:1.68E-6 ID:SGTC_2683|Compound:piperine|FD-Score:3.02|P-value:7.55E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:4.45|P-value:1.47E-6 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.45|P-value:1.45E-6 ID:SGTC_2816|Compound:7982706|FD-Score:-3.24|P-value:3.55E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-4.13|P-value:7.69E-6 ID:SGTC_2825|Compound:7998094|FD-Score:-3.30|P-value:2.80E-4 ID:SGTC_2841|Compound:9004761|FD-Score:2.96|P-value:9.21E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-3.80|P-value:3.55E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-4.51|P-value:1.20E-6 ID:SGTC_3138|Compound:9097216|FD-Score:-3.46|P-value:1.46E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-3.96|P-value:1.73E-5 ID:SGTC_3151|Compound:9099821|FD-Score:-3.03|P-value:7.55E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-3.05|P-value:7.23E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.91|P-value:1.99E-5 ID:SGTC_3328|Compound:9140624|FD-Score:4.11|P-value:7.88E-6

Top fitness defect scores for YOR334W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_70 0141-0289 6.42 43.3 µM 7.87E-12 mitochondrial stress 68 6.76E-11
2 SGTC_1230 0170-0365 5.86 3.8 µM 3.92E-10 endomembrane recycling 21 2.37E-9
3 SGTC_236 1509-0011 4.57 5.3 µM 7.85E-7 355 2.41E-6
4 SGTC_1300 1094-0077 4.57 113.0 µM 7.92E-7 5 2.43E-6
5 SGTC_2767 sibutramine 4.45 71.5 µM 1.45E-6 11 4.22E-6
6 SGTC_2732 terfenadine 4.45 20.0 µM 1.47E-6 ERG2 3 4.29E-6
7 SGTC_2592 piperlongumine 4.42 83.3 µM 1.68E-6 TSC3-RPN4 23 4.84E-6
8 SGTC_310 1273-0058 4.35 1.1 µM 2.42E-6 mitochondrial stress 221 6.75E-6
9 SGTC_1196 1588-0294 4.18 184.0 µM 5.69E-6 9 1.47E-5
10 SGTC_3328 9140624 4.11 29.0 µM 7.88E-6 17 1.98E-5
11 SGTC_2332 7982454 4.08 138.9 µM 9.21E-6 41 2.28E-5
12 SGTC_1223 0764-0573 4.03 147.0 µM 1.14E-5 20 2.77E-5
13 SGTC_2291 7917025 3.92 104.3 µM 1.95E-5 iron homeostasis 48 4.52E-5
14 SGTC_3323 9138564 3.91 53.9 µM 1.99E-5 20 4.60E-5
15 SGTC_638 3970-0837 3.89 4.1 µM 2.15E-5 40 4.95E-5
16 SGTC_1036 k216-0215 3.87 33.5 µM 2.42E-5 mitochondrial response to ROS 55 5.49E-5
17 SGTC_1526 st051518 3.77 75.0 µM 3.78E-5 26 8.26E-5
18 SGTC_680 0417-1641 3.67 114.0 µM 5.88E-5 RPP1 & pyrimidine depletion 21 1.24E-4
19 SGTC_489 paxilline 3.63 115.0 µM 6.93E-5 PDR1 23 1.44E-4
20 SGTC_2053 5265679 3.59 138.0 µM 8.13E-5 34 1.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.182 2.25E-26 YDR065W RRG1 hom Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.178 2.44E-25 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.177 6.01E-25 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.175 1.47E-24 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.167 1.61E-22 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.166 4.04E-22 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.164 1.54E-21 YDR529C QCR7 hom Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly
0.163 2.13E-21 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.161 6.76E-21 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.157 6.25E-20 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.156 9.22E-20 YGL143C MRF1 hom Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability
0.155 1.39E-19 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.154 3.10E-19 YGR101W PCP1 hom Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases
0.152 6.70E-19 YMR138W CIN4 hom GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog
0.152 8.63E-19 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs