HIPHOP chemogenomics database
YOR334W / MRS2 
Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOR334W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.182 | 2.25E-26 | YDR065W | RRG1 | hom | Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.178 | 2.44E-25 | YLL033W | IRC19 | hom | Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci |
| 0.177 | 6.01E-25 | YGR220C | MRPL9 | hom | Mitochondrial ribosomal protein of the large subunit |
| 0.175 | 1.47E-24 | YJL023C | PET130 | hom | Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.167 | 1.61E-22 | YPL078C | ATP4 | hom | Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated |
| 0.166 | 4.04E-22 | YER141W | COX15 | hom | Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase |
| 0.164 | 1.54E-21 | YDR529C | QCR7 | hom | Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly |
| 0.163 | 2.13E-21 | YDR509W_d | YDR509W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.161 | 6.76E-21 | YLR260W | LCB5 | hom | Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules |
| 0.157 | 6.25E-20 | YOR065W | CYT1 | hom | Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex |
| 0.156 | 9.22E-20 | YGL143C | MRF1 | hom | Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability |
| 0.155 | 1.39E-19 | YCR024C | SLM5 | hom | Mitochondrial asparaginyl-tRNA synthetase |
| 0.154 | 3.10E-19 | YGR101W | PCP1 | hom | Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases |
| 0.152 | 6.70E-19 | YMR138W | CIN4 | hom | GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog |
| 0.152 | 8.63E-19 | YMR287C | DSS1 | hom | 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs |