YOR357C / SNX3

Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR357C / SNX3

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.91|P-value:5.45E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:3.41|P-value:3.81E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:4.30|P-value:1.06E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:6.96|P-value:3.11E-12 ID:SGTC_178|Compound:4092-0806|FD-Score:5.22|P-value:1.26E-7 ID:SGTC_197|Compound:4544-0043|FD-Score:3.21|P-value:7.43E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:7.63|P-value:2.35E-14 ID:SGTC_221|Compound:trifluoperazine|FD-Score:14.70|P-value:4.35E-48 ID:SGTC_232|Compound:clozapine|FD-Score:3.87|P-value:6.52E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:3.57|P-value:2.09E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.13|P-value:9.92E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:5.69|P-value:9.54E-9 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.13|P-value:9.94E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.91|P-value:6.01E-7 ID:SGTC_449|Compound:xestospongin c|FD-Score:7.38|P-value:1.52E-13 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.89|P-value:6.33E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.44|P-value:3.35E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.33|P-value:4.93E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.28|P-value:6.08E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:5.04|P-value:3.10E-7 ID:SGTC_658|Compound:3253-0951|FD-Score:3.17|P-value:8.65E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.69|P-value:1.32E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.13|P-value:9.77E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.23|P-value:7.12E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.34|P-value:4.87E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.21|P-value:7.42E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:4.60|P-value:2.76E-6 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.22|P-value:7.52E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:4.84|P-value:8.53E-7 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.19|P-value:8.05E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.50|P-value:4.32E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:6.62|P-value:3.09E-11 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.95|P-value:4.89E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.27|P-value:6.04E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.02|P-value:3.59E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.01|P-value:3.73E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.85|P-value:7.04E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.89|P-value:6.09E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.51|P-value:4.10E-6 ID:SGTC_1712|Compound:st032288|FD-Score:3.65|P-value:1.51E-4 ID:SGTC_1754|Compound:st042065|FD-Score:6.90|P-value:4.56E-12 ID:SGTC_1760|Compound:st045453|FD-Score:5.03|P-value:3.31E-7 ID:SGTC_1800|Compound:st050079|FD-Score:6.82|P-value:7.79E-12 ID:SGTC_1801|Compound:st050089|FD-Score:12.00|P-value:1.23E-32 ID:SGTC_1803|Compound:st050068|FD-Score:12.90|P-value:1.38E-37 ID:SGTC_1818|Compound:st052136|FD-Score:6.77|P-value:1.13E-11 ID:SGTC_1923|Compound:st058458|FD-Score:3.54|P-value:2.37E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.61|P-value:1.83E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.86|P-value:6.91E-5 ID:SGTC_2083|Compound:5306046|FD-Score:5.26|P-value:1.03E-7 ID:SGTC_2245|Compound:6637752|FD-Score:-6.48|P-value:8.11E-11 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.22|P-value:7.37E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.40|P-value:4.79E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.84|P-value:8.62E-7 ID:SGTC_2255|Compound:7941087|FD-Score:3.16|P-value:8.98E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.91|P-value:5.49E-5 ID:SGTC_2289|Compound:7946404|FD-Score:3.54|P-value:2.30E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.39|P-value:4.11E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.96|P-value:4.44E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.68|P-value:1.35E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.66|P-value:1.51E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.72|P-value:1.16E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.13|P-value:9.77E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.37|P-value:7.97E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:6.44|P-value:9.86E-11 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.44|P-value:3.44E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.36|P-value:4.43E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.75|P-value:1.10E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.63|P-value:2.33E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.99|P-value:4.12E-7 ID:SGTC_2896|Compound:9052656|FD-Score:3.59|P-value:1.92E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-4.17|P-value:1.98E-5 ID:SGTC_3123|Compound:9126162|FD-Score:-3.30|P-value:5.58E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.15|P-value:2.08E-5 ID:SGTC_3144|Compound:9087057|FD-Score:3.70|P-value:1.26E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.07|P-value:2.86E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.58|P-value:1.97E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.75|P-value:1.05E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.90|P-value:5.84E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.91|P-value:5.45E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:3.41|P-value:3.81E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:4.30|P-value:1.06E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:6.96|P-value:3.11E-12 ID:SGTC_178|Compound:4092-0806|FD-Score:5.22|P-value:1.26E-7 ID:SGTC_197|Compound:4544-0043|FD-Score:3.21|P-value:7.43E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:7.63|P-value:2.35E-14 ID:SGTC_221|Compound:trifluoperazine|FD-Score:14.70|P-value:4.35E-48 ID:SGTC_232|Compound:clozapine|FD-Score:3.87|P-value:6.52E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:3.57|P-value:2.09E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.13|P-value:9.92E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:5.69|P-value:9.54E-9 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.13|P-value:9.94E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.91|P-value:6.01E-7 ID:SGTC_449|Compound:xestospongin c|FD-Score:7.38|P-value:1.52E-13 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.89|P-value:6.33E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.44|P-value:3.35E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.33|P-value:4.93E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.28|P-value:6.08E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:5.04|P-value:3.10E-7 ID:SGTC_658|Compound:3253-0951|FD-Score:3.17|P-value:8.65E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.69|P-value:1.32E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.13|P-value:9.77E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.23|P-value:7.12E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.34|P-value:4.87E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.21|P-value:7.42E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:4.60|P-value:2.76E-6 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.22|P-value:7.52E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:4.84|P-value:8.53E-7 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.19|P-value:8.05E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.50|P-value:4.32E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:6.62|P-value:3.09E-11 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.95|P-value:4.89E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.27|P-value:6.04E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.02|P-value:3.59E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.01|P-value:3.73E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.85|P-value:7.04E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.89|P-value:6.09E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.51|P-value:4.10E-6 ID:SGTC_1712|Compound:st032288|FD-Score:3.65|P-value:1.51E-4 ID:SGTC_1754|Compound:st042065|FD-Score:6.90|P-value:4.56E-12 ID:SGTC_1760|Compound:st045453|FD-Score:5.03|P-value:3.31E-7 ID:SGTC_1800|Compound:st050079|FD-Score:6.82|P-value:7.79E-12 ID:SGTC_1801|Compound:st050089|FD-Score:12.00|P-value:1.23E-32 ID:SGTC_1803|Compound:st050068|FD-Score:12.90|P-value:1.38E-37 ID:SGTC_1818|Compound:st052136|FD-Score:6.77|P-value:1.13E-11 ID:SGTC_1923|Compound:st058458|FD-Score:3.54|P-value:2.37E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.61|P-value:1.83E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.86|P-value:6.91E-5 ID:SGTC_2083|Compound:5306046|FD-Score:5.26|P-value:1.03E-7 ID:SGTC_2245|Compound:6637752|FD-Score:-6.48|P-value:8.11E-11 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.22|P-value:7.37E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.40|P-value:4.79E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.84|P-value:8.62E-7 ID:SGTC_2255|Compound:7941087|FD-Score:3.16|P-value:8.98E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.91|P-value:5.49E-5 ID:SGTC_2289|Compound:7946404|FD-Score:3.54|P-value:2.30E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.39|P-value:4.11E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.96|P-value:4.44E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.68|P-value:1.35E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.66|P-value:1.51E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.72|P-value:1.16E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.13|P-value:9.77E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.37|P-value:7.97E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:6.44|P-value:9.86E-11 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.44|P-value:3.44E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.36|P-value:4.43E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.75|P-value:1.10E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.63|P-value:2.33E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.99|P-value:4.12E-7 ID:SGTC_2896|Compound:9052656|FD-Score:3.59|P-value:1.92E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-4.17|P-value:1.98E-5 ID:SGTC_3123|Compound:9126162|FD-Score:-3.30|P-value:5.58E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.15|P-value:2.08E-5 ID:SGTC_3144|Compound:9087057|FD-Score:3.70|P-value:1.26E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.07|P-value:2.86E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.58|P-value:1.97E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.75|P-value:1.05E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.90|P-value:5.84E-5

Top fitness defect scores for YOR357C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_221 trifluoperazine 14.70 10.3 µM 4.35E-48 NEO1-PIK1 24 3.12E-49
2 SGTC_1803 st050068 12.90 52.4 µM 1.38E-37 NEO1-PIK1 7 1.80E-38
3 SGTC_1801 st050089 12.00 28.4 µM 1.23E-32 NEO1-PIK1 7 2.15E-33
4 SGTC_206 4546-0025 7.63 72.0 µM 2.35E-14 NEO1 26 1.16E-14
5 SGTC_449 xestospongin c 7.38 11.2 µM 1.52E-13 NEO1-PIK1 7 7.88E-14
6 SGTC_146 3448-8650 6.96 53.1 µM 3.11E-12 NEO1-PIK1 36 1.73E-12
7 SGTC_1754 st042065 6.90 16.1 µM 4.56E-12 NEO1-PIK1 75 2.56E-12
8 SGTC_1800 st050079 6.82 29.1 µM 7.79E-12 NEO1-PIK1 27 4.44E-12
9 SGTC_1818 st052136 6.77 56.3 µM 1.13E-11 NEO1-PIK1 9 6.49E-12
10 SGTC_1127 asiatic acid 6.62 681.4 nM 3.09E-11 2 1.82E-11
11 SGTC_2567 aureobasidin a 6.44 60.0 nM 9.86E-11 36 5.98E-11
12 SGTC_439 amiodarone 5.69 34.4 µM 9.54E-9 NEO1-PIK1 49 6.46E-9
13 SGTC_2249 haloperidol 5.40 116.4 µM 4.79E-8 ergosterol depletion effects on membrane 55 3.37E-8
14 SGTC_2083 5306046 5.26 65.9 µM 1.03E-7 4 7.40E-8
15 SGTC_178 4092-0806 5.22 87.5 µM 1.26E-7 ergosterol depletion effects on membrane 52 9.08E-8
16 SGTC_649 1123-0311 5.04 367.0 µM 3.10E-7 endomembrane recycling 38 2.28E-7
17 SGTC_1760 st045453 5.03 10.4 µM 3.31E-7 NEO1-PIK1 108 2.44E-7
18 SGTC_2688 kanamycin b 4.99 96.7 µM 4.12E-7 calcium & mitochondrial duress 245 3.05E-7
19 SGTC_445 e6 berbamine 4.91 66.0 µM 6.01E-7 NEO1-PIK1 67 4.49E-7
20 SGTC_978 1416-0512 4.84 87.4 µM 8.53E-7 redox potentiating 16 6.43E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.536 1.51E-249 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.484 3.02E-196 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.479 4.52E-192 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.464 3.23E-179 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.461 6.35E-176 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.458 1.73E-173 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.447 7.64E-165 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.438 3.13E-157 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.429 1.16E-150 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.406 2.29E-133 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.403 3.46E-131 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.399 3.05E-128 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.394 6.76E-125 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.392 1.39E-123 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.382 7.56E-117 YDR492W IZH1 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc