YOR363C / PIP2

Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR363C / PIP2

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.21|P-value:7.99E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-4.51|P-value:7.39E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:11.40|P-value:8.71E-29 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.69|P-value:1.48E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.66|P-value:1.59E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:4.05|P-value:3.57E-5 ID:SGTC_271|Compound:rotenone|FD-Score:3.29|P-value:6.02E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.50|P-value:2.87E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.65|P-value:1.71E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.56|P-value:2.38E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.30|P-value:5.94E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-5.58|P-value:3.81E-8 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.50|P-value:5.25E-6 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.25|P-value:6.96E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.94|P-value:5.97E-12 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.57|P-value:3.07E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.36|P-value:4.69E-4 ID:SGTC_1722|Compound:st034304|FD-Score:4.01|P-value:4.09E-5 ID:SGTC_1822|Compound:st052468|FD-Score:3.24|P-value:7.27E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.50|P-value:3.93E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.26|P-value:6.61E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.20|P-value:1.92E-5 ID:SGTC_2098|Compound:5376439|FD-Score:-3.36|P-value:6.50E-4 ID:SGTC_2100|Compound:5377183|FD-Score:-4.41|P-value:1.13E-5 ID:SGTC_2156|Compound:5649887|FD-Score:3.31|P-value:5.70E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.30|P-value:7.94E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.72|P-value:1.30E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:5.66|P-value:1.58E-8 ID:SGTC_2516|Compound:gossypol|FD-Score:3.39|P-value:4.24E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.05|P-value:5.12E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:3.38|P-value:4.47E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-4.07|P-value:4.67E-5 ID:SGTC_3076|Compound:9116187|FD-Score:4.61|P-value:3.18E-6 ID:SGTC_3217|Compound:9129673|FD-Score:-5.50|P-value:5.92E-8 ID:SGTC_3278|Compound:9139605|FD-Score:4.10|P-value:2.88E-5 ID:SGTC_3340|Compound:9146634|FD-Score:4.06|P-value:3.42E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:3.21|P-value:7.99E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-4.51|P-value:7.39E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:11.40|P-value:8.71E-29 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.69|P-value:1.48E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.66|P-value:1.59E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:4.05|P-value:3.57E-5 ID:SGTC_271|Compound:rotenone|FD-Score:3.29|P-value:6.02E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.50|P-value:2.87E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.65|P-value:1.71E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.56|P-value:2.38E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.30|P-value:5.94E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-5.58|P-value:3.81E-8 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.50|P-value:5.25E-6 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.25|P-value:6.96E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.94|P-value:5.97E-12 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.57|P-value:3.07E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.36|P-value:4.69E-4 ID:SGTC_1722|Compound:st034304|FD-Score:4.01|P-value:4.09E-5 ID:SGTC_1822|Compound:st052468|FD-Score:3.24|P-value:7.27E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.50|P-value:3.93E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.26|P-value:6.61E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.20|P-value:1.92E-5 ID:SGTC_2098|Compound:5376439|FD-Score:-3.36|P-value:6.50E-4 ID:SGTC_2100|Compound:5377183|FD-Score:-4.41|P-value:1.13E-5 ID:SGTC_2156|Compound:5649887|FD-Score:3.31|P-value:5.70E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.30|P-value:7.94E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.72|P-value:1.30E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:5.66|P-value:1.58E-8 ID:SGTC_2516|Compound:gossypol|FD-Score:3.39|P-value:4.24E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.05|P-value:5.12E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:3.38|P-value:4.47E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-4.07|P-value:4.67E-5 ID:SGTC_3076|Compound:9116187|FD-Score:4.61|P-value:3.18E-6 ID:SGTC_3217|Compound:9129673|FD-Score:-5.50|P-value:5.92E-8 ID:SGTC_3278|Compound:9139605|FD-Score:4.10|P-value:2.88E-5 ID:SGTC_3340|Compound:9146634|FD-Score:4.06|P-value:3.42E-5

Top fitness defect scores for YOR363C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_103 0844-0104 11.40 51.8 µM 8.71E-29 ERAD & cell cycle 23 3.23E-30
2 SGTC_1161 k007-0610 6.94 110.0 µM 5.97E-12 ERAD & cell cycle 39 1.92E-12
3 SGTC_2514 salinomycin 5.66 42.7 µM 1.58E-8 18 7.74E-9
4 SGTC_3076 9116187 4.61 49.5 µM 3.18E-6 9 2.04E-6
5 SGTC_915 methyl methanesulfonate (MMS) 4.50 110.0 mM 5.25E-6 DNA damage response 26 3.46E-6
6 SGTC_2019 4016004 4.20 108.0 µM 1.92E-5 24 1.35E-5
7 SGTC_3278 9139605 4.10 49.5 µM 2.88E-5 10 2.06E-5
8 SGTC_3340 9146634 4.06 11.1 µM 3.42E-5 11 2.47E-5
9 SGTC_198 3454-2873 4.05 16.2 µM 3.57E-5 60S ribosome export 12 2.58E-5
10 SGTC_1722 st034304 4.01 3.6 µM 4.09E-5 mitochondrial processes 24 2.97E-5
11 SGTC_2502 avocadyne acetate 3.72 18.6 µM 1.30E-4 32 1.00E-4
12 SGTC_120 rhodamine 6G 3.69 52.3 µM 1.48E-4 mitochondrial processes 44 1.14E-4
13 SGTC_129 0088-0017 3.66 176.6 µM 1.59E-4 74 1.24E-4
14 SGTC_384 k007-0144 3.65 5.2 µM 1.71E-4 ERAD & cell cycle 67 1.33E-4
15 SGTC_426 0988-0037 3.56 14.6 µM 2.38E-4 ERAD & cell cycle 50 1.88E-4
16 SGTC_361 000s-0510 3.50 1.4 µM 2.87E-4 49 2.28E-4
17 SGTC_2516 gossypol 3.39 71.5 µM 4.24E-4 31 3.44E-4
18 SGTC_2736 butenafine 3.38 14.7 µM 4.47E-4 47 3.64E-4
19 SGTC_1531 st059297 3.36 52.4 µM 4.69E-4 39 3.83E-4
20 SGTC_2156 5649887 3.31 115.0 µM 5.70E-4 RPP1 & pyrimidine depletion 35 4.69E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.397 4.12E-127 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.312 8.73E-77 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.279 5.06E-61 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.274 6.36E-59 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.260 3.90E-53 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.259 1.27E-52 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.246 2.18E-47 YDL126C CDC48 het AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
0.227 1.49E-40 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.224 1.46E-39 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
0.223 3.31E-39 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.219 1.32E-37 YAL051W OAF1 hom Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication
0.219 1.49E-37 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.217 6.49E-37 YML105C SEC65 het Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19
0.217 5.95E-37 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.213 7.32E-36 YMR052W FAR3 hom Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress