YOR364W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR364W / YOR364W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:2.94|P-value:7.23E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.26|P-value:2.28E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-2.91|P-value:9.11E-4 ID:SGTC_394|Compound:menadione|FD-Score:4.15|P-value:3.57E-6 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.25|P-value:2.40E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.34|P-value:1.48E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-4.94|P-value:5.54E-8 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.49|P-value:9.08E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.01|P-value:6.10E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:-2.88|P-value:9.92E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:12.10|P-value:2.91E-39 ID:SGTC_919|Compound:tnp00227|FD-Score:3.28|P-value:1.93E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.89|P-value:1.49E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:-4.17|P-value:3.64E-6 ID:SGTC_953|Compound:1188-0045|FD-Score:3.05|P-value:4.71E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:2.87|P-value:9.31E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.32|P-value:1.79E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:2.99|P-value:6.03E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.27|P-value:2.02E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.52|P-value:7.03E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:-3.72|P-value:3.17E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.39|P-value:1.34E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.74|P-value:3.00E-5 ID:SGTC_1726|Compound:st035556|FD-Score:4.08|P-value:5.19E-6 ID:SGTC_1730|Compound:st033808|FD-Score:-3.07|P-value:4.84E-4 ID:SGTC_1763|Compound:st044482|FD-Score:3.62|P-value:4.49E-5 ID:SGTC_1919|Compound:st067113|FD-Score:4.55|P-value:4.30E-7 ID:SGTC_1931|Compound:st074438|FD-Score:-3.44|P-value:1.09E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.54|P-value:7.17E-5 ID:SGTC_2238|Compound:6671620|FD-Score:-3.26|P-value:2.34E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.51|P-value:7.14E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.97|P-value:8.92E-6 ID:SGTC_2333|Compound:9017922|FD-Score:4.22|P-value:2.54E-6 ID:SGTC_2338|Compound:7999974|FD-Score:2.98|P-value:6.30E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.39|P-value:1.20E-4 ID:SGTC_2359|Compound:9039622|FD-Score:4.04|P-value:6.22E-6 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.63|P-value:3.21E-7 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.28|P-value:2.17E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-6.17|P-value:1.63E-11 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.54|P-value:6.24E-5 ID:SGTC_2809|Compound:7964133|FD-Score:3.28|P-value:1.92E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-7.52|P-value:2.89E-16 ID:SGTC_2876|Compound:9059903|FD-Score:2.91|P-value:8.02E-4 ID:SGTC_2917|Compound:7979103|FD-Score:2.94|P-value:7.27E-4 ID:SGTC_3058|Compound:9093861|FD-Score:-3.26|P-value:2.31E-4 ID:SGTC_3103|Compound:9120822|FD-Score:2.92|P-value:7.84E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-3.77|P-value:2.51E-5 ID:SGTC_3136|Compound:9095672|FD-Score:2.98|P-value:6.22E-4 ID:SGTC_3139|Compound:9095020|FD-Score:4.05|P-value:5.79E-6 ID:SGTC_3282|Compound:9108498|FD-Score:3.53|P-value:6.56E-5 ID:SGTC_3286|Compound:9117135|FD-Score:3.38|P-value:1.24E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.85|P-value:1.81E-5 ID:SGTC_3331|Compound:9141060|FD-Score:-3.25|P-value:2.38E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:2.94|P-value:7.23E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.26|P-value:2.28E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-2.91|P-value:9.11E-4 ID:SGTC_394|Compound:menadione|FD-Score:4.15|P-value:3.57E-6 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.25|P-value:2.40E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.34|P-value:1.48E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-4.94|P-value:5.54E-8 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.49|P-value:9.08E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.01|P-value:6.10E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:-2.88|P-value:9.92E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:12.10|P-value:2.91E-39 ID:SGTC_919|Compound:tnp00227|FD-Score:3.28|P-value:1.93E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.89|P-value:1.49E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:-4.17|P-value:3.64E-6 ID:SGTC_953|Compound:1188-0045|FD-Score:3.05|P-value:4.71E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:2.87|P-value:9.31E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.32|P-value:1.79E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:2.99|P-value:6.03E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.27|P-value:2.02E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.52|P-value:7.03E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:-3.72|P-value:3.17E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.39|P-value:1.34E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.74|P-value:3.00E-5 ID:SGTC_1726|Compound:st035556|FD-Score:4.08|P-value:5.19E-6 ID:SGTC_1730|Compound:st033808|FD-Score:-3.07|P-value:4.84E-4 ID:SGTC_1763|Compound:st044482|FD-Score:3.62|P-value:4.49E-5 ID:SGTC_1919|Compound:st067113|FD-Score:4.55|P-value:4.30E-7 ID:SGTC_1931|Compound:st074438|FD-Score:-3.44|P-value:1.09E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.54|P-value:7.17E-5 ID:SGTC_2238|Compound:6671620|FD-Score:-3.26|P-value:2.34E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.51|P-value:7.14E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.97|P-value:8.92E-6 ID:SGTC_2333|Compound:9017922|FD-Score:4.22|P-value:2.54E-6 ID:SGTC_2338|Compound:7999974|FD-Score:2.98|P-value:6.30E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.39|P-value:1.20E-4 ID:SGTC_2359|Compound:9039622|FD-Score:4.04|P-value:6.22E-6 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.63|P-value:3.21E-7 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.28|P-value:2.17E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-6.17|P-value:1.63E-11 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.54|P-value:6.24E-5 ID:SGTC_2809|Compound:7964133|FD-Score:3.28|P-value:1.92E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-7.52|P-value:2.89E-16 ID:SGTC_2876|Compound:9059903|FD-Score:2.91|P-value:8.02E-4 ID:SGTC_2917|Compound:7979103|FD-Score:2.94|P-value:7.27E-4 ID:SGTC_3058|Compound:9093861|FD-Score:-3.26|P-value:2.31E-4 ID:SGTC_3103|Compound:9120822|FD-Score:2.92|P-value:7.84E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-3.77|P-value:2.51E-5 ID:SGTC_3136|Compound:9095672|FD-Score:2.98|P-value:6.22E-4 ID:SGTC_3139|Compound:9095020|FD-Score:4.05|P-value:5.79E-6 ID:SGTC_3282|Compound:9108498|FD-Score:3.53|P-value:6.56E-5 ID:SGTC_3286|Compound:9117135|FD-Score:3.38|P-value:1.24E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.85|P-value:1.81E-5 ID:SGTC_3331|Compound:9141060|FD-Score:-3.25|P-value:2.38E-4

Top fitness defect scores for YOR364W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_690 glyoxal 12.10 20.3 µM 2.91E-39 12 5.48E-34
2 SGTC_1919 st067113 4.55 52.3 µM 4.30E-7 TSC3-RPN4 19 2.67E-6
3 SGTC_2333 9017922 4.22 200.0 µM 2.54E-6 19 1.24E-5
4 SGTC_394 menadione 4.15 8.3 µM 3.57E-6 superoxide 25 1.66E-5
5 SGTC_1726 st035556 4.08 14.6 µM 5.19E-6 32 2.29E-5
6 SGTC_3139 9095020 4.05 49.5 µM 5.79E-6 5 2.52E-5
7 SGTC_2359 9039622 4.04 200.0 µM 6.22E-6 endomembrane recycling 21 2.68E-5
8 SGTC_2297 7971671 3.97 152.3 µM 8.92E-6 RNA processing & uracil transport 24 3.66E-5
9 SGTC_1763 st044482 3.62 94.5 µM 4.49E-5 copper-dependent oxidative stress 26 1.48E-4
10 SGTC_2742 clothiapine 3.54 36.3 µM 6.24E-5 NEO1 20 1.97E-4
11 SGTC_3282 9108498 3.53 15.5 µM 6.56E-5 42 2.05E-4
12 SGTC_1453 4237-0541 3.52 195.0 µM 7.03E-5 heme biosynthesis & mitochondrial translocase 38 2.18E-4
13 SGTC_2259 7964009 3.51 200.0 µM 7.14E-5 superoxide 46 2.21E-4
14 SGTC_2350 9023895 3.39 38.9 µM 1.20E-4 ergosterol biosynthesis 47 3.46E-4
15 SGTC_3286 9117135 3.38 37.2 µM 1.24E-4 37 3.57E-4
16 SGTC_426 0988-0037 3.34 14.6 µM 1.48E-4 ERAD & cell cycle 62 4.14E-4
17 SGTC_2809 7964133 3.28 13.0 µM 1.92E-4 60S ribosome export 74 5.18E-4
18 SGTC_919 tnp00227 3.28 403.6 nM 1.93E-4 RNA pol III & RNase P/MRP 73 5.21E-4
19 SGTC_1448 4255-0083 3.27 152.0 µM 2.02E-4 ERG2 37 5.43E-4
20 SGTC_953 1188-0045 3.05 9.7 µM 4.71E-4 60S ribosome export 69 0.00113

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.263 3.28E-54 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.213 6.99E-36 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.210 1.54E-34 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.196 2.18E-30 YNR031C SSK2 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress
0.175 1.85E-24 YJL110C GZF3 hom GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication
0.173 4.54E-24 YLR113W HOG1 hom Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress
0.157 5.05E-20 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.156 1.20E-19 YBL024W NCL1 hom S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120
0.154 2.46E-19 YNL307C MCK1 hom Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family
0.151 1.15E-18 YLR193C UPS1 hom Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI
0.144 4.83E-17 YMR275C BUL1 hom Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication
0.142 1.61E-16 YGL133W ITC1 hom Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex
0.136 2.49E-15 YGR191W HIP1 het High-affinity histidine permease, also involved in the transport of manganese ions
0.134 6.93E-15 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.130 3.95E-14 YHR009C_p TDA3_p hom Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1