YOR377W / ATF1

Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR377W / ATF1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:3.43|P-value:5.96E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:2.82|P-value:7.80E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.93|P-value:5.20E-6 ID:SGTC_305|Compound:1682-2595|FD-Score:3.12|P-value:2.31E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:-3.16|P-value:1.97E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-4.12|P-value:1.90E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:3.57|P-value:3.16E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:-2.92|P-value:5.30E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-2.96|P-value:4.58E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-2.92|P-value:5.34E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:4.47|P-value:2.64E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:3.38|P-value:7.58E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:2.96|P-value:4.45E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:2.83|P-value:7.51E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.24|P-value:1.36E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:4.42|P-value:3.53E-7 ID:SGTC_1020|Compound:4335-0961|FD-Score:-2.85|P-value:7.00E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-4.70|P-value:6.91E-8 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.12|P-value:2.33E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.86|P-value:6.70E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.90|P-value:6.05E-6 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.07|P-value:2.88E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.77|P-value:4.46E-8 ID:SGTC_1296|Compound:1068-0102|FD-Score:2.99|P-value:3.93E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.74|P-value:1.38E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.90|P-value:6.05E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.72|P-value:7.12E-11 ID:SGTC_1590|Compound:st077108|FD-Score:3.33|P-value:9.39E-5 ID:SGTC_1745|Compound:st081495|FD-Score:2.99|P-value:3.97E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.14|P-value:2.08E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.10|P-value:2.60E-4 ID:SGTC_1791|Compound:st048313|FD-Score:5.97|P-value:1.04E-11 ID:SGTC_1795|Compound:st049545|FD-Score:5.12|P-value:4.73E-9 ID:SGTC_1906|Compound:st060206|FD-Score:3.58|P-value:2.98E-5 ID:SGTC_1978|Compound:st071761|FD-Score:-3.06|P-value:3.07E-4 ID:SGTC_1986|Compound:st071812|FD-Score:2.81|P-value:8.20E-4 ID:SGTC_1992|Compound:st073643|FD-Score:-3.28|P-value:1.17E-4 ID:SGTC_1998|Compound:st075797|FD-Score:2.87|P-value:6.43E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-2.94|P-value:4.85E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-2.76|P-value:9.76E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.42|P-value:6.29E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.53|P-value:3.73E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:-2.91|P-value:5.55E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.87|P-value:2.37E-8 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.40|P-value:4.06E-7 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.48|P-value:4.80E-5 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.81|P-value:9.68E-6 ID:SGTC_2678|Compound:equilin|FD-Score:3.46|P-value:5.20E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.50|P-value:1.47E-13 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.78|P-value:1.11E-5 ID:SGTC_2803|Compound:7707263|FD-Score:-3.31|P-value:1.06E-4 ID:SGTC_2860|Compound:9025725|FD-Score:2.86|P-value:6.60E-4 ID:SGTC_2868|Compound:9035608|FD-Score:4.59|P-value:1.28E-7 ID:SGTC_2937|Compound:9044753|FD-Score:-3.38|P-value:7.62E-5 ID:SGTC_3093|Compound:9117344|FD-Score:3.22|P-value:1.53E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.87|P-value:6.94E-6 ID:SGTC_3219|Compound:9131112|FD-Score:3.44|P-value:5.70E-5 ID:SGTC_3334|Compound:9142812|FD-Score:3.30|P-value:1.05E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.43|P-value:5.96E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:2.82|P-value:7.80E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.93|P-value:5.20E-6 ID:SGTC_305|Compound:1682-2595|FD-Score:3.12|P-value:2.31E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:-3.16|P-value:1.97E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-4.12|P-value:1.90E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:3.57|P-value:3.16E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:-2.92|P-value:5.30E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-2.96|P-value:4.58E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-2.92|P-value:5.34E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:4.47|P-value:2.64E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:3.38|P-value:7.58E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:2.96|P-value:4.45E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:2.83|P-value:7.51E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.24|P-value:1.36E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:4.42|P-value:3.53E-7 ID:SGTC_1020|Compound:4335-0961|FD-Score:-2.85|P-value:7.00E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-4.70|P-value:6.91E-8 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.12|P-value:2.33E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.86|P-value:6.70E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.90|P-value:6.05E-6 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.07|P-value:2.88E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.77|P-value:4.46E-8 ID:SGTC_1296|Compound:1068-0102|FD-Score:2.99|P-value:3.93E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.74|P-value:1.38E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.90|P-value:6.05E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.72|P-value:7.12E-11 ID:SGTC_1590|Compound:st077108|FD-Score:3.33|P-value:9.39E-5 ID:SGTC_1745|Compound:st081495|FD-Score:2.99|P-value:3.97E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.14|P-value:2.08E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.10|P-value:2.60E-4 ID:SGTC_1791|Compound:st048313|FD-Score:5.97|P-value:1.04E-11 ID:SGTC_1795|Compound:st049545|FD-Score:5.12|P-value:4.73E-9 ID:SGTC_1906|Compound:st060206|FD-Score:3.58|P-value:2.98E-5 ID:SGTC_1978|Compound:st071761|FD-Score:-3.06|P-value:3.07E-4 ID:SGTC_1986|Compound:st071812|FD-Score:2.81|P-value:8.20E-4 ID:SGTC_1992|Compound:st073643|FD-Score:-3.28|P-value:1.17E-4 ID:SGTC_1998|Compound:st075797|FD-Score:2.87|P-value:6.43E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-2.94|P-value:4.85E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-2.76|P-value:9.76E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.42|P-value:6.29E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.53|P-value:3.73E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:-2.91|P-value:5.55E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.87|P-value:2.37E-8 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.40|P-value:4.06E-7 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.48|P-value:4.80E-5 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.81|P-value:9.68E-6 ID:SGTC_2678|Compound:equilin|FD-Score:3.46|P-value:5.20E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.50|P-value:1.47E-13 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.78|P-value:1.11E-5 ID:SGTC_2803|Compound:7707263|FD-Score:-3.31|P-value:1.06E-4 ID:SGTC_2860|Compound:9025725|FD-Score:2.86|P-value:6.60E-4 ID:SGTC_2868|Compound:9035608|FD-Score:4.59|P-value:1.28E-7 ID:SGTC_2937|Compound:9044753|FD-Score:-3.38|P-value:7.62E-5 ID:SGTC_3093|Compound:9117344|FD-Score:3.22|P-value:1.53E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.87|P-value:6.94E-6 ID:SGTC_3219|Compound:9131112|FD-Score:3.44|P-value:5.70E-5 ID:SGTC_3334|Compound:9142812|FD-Score:3.30|P-value:1.05E-4

Top fitness defect scores for YOR377W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 6.50 96.7 µM 1.47E-13 calcium & mitochondrial duress 130 3.91E-11
2 SGTC_1791 st048313 5.97 56.1 µM 1.04E-11 1 1.17E-9
3 SGTC_1795 st049545 5.12 62.3 µM 4.73E-9 TSC3-RPN4 5 1.56E-7
4 SGTC_2582 agaric acid 4.87 100.0 µM 2.37E-8 redox potentiating 230 5.66E-7
5 SGTC_1275 0867-0008 4.77 21.1 µM 4.46E-8 6 9.39E-7
6 SGTC_2868 9035608 4.59 32.5 µM 1.28E-7 7 2.19E-6
7 SGTC_554 4483-2211 4.47 187.0 µM 2.64E-7 12 3.91E-6
8 SGTC_950 1165-0508 4.42 94.1 µM 3.53E-7 17 4.94E-6
9 SGTC_2583 asiatic acid 4.40 100.0 µM 4.06E-7 27 5.51E-6
10 SGTC_294 k038-0071 3.93 157.0 µM 5.20E-6 ubiquinone biosynthesis & proteasome 66 4.27E-5
11 SGTC_1252 0493-0875 3.90 34.8 µM 6.05E-6 31 4.82E-5
12 SGTC_3181 9108277 3.87 49.5 µM 6.94E-6 iron homeostasis 17 5.39E-5
13 SGTC_2667 digitoxin 3.81 100.0 µM 9.68E-6 4 7.03E-5
14 SGTC_1457 k015-0032 3.74 57.3 µM 1.38E-5 42 9.33E-5
15 SGTC_1906 st060206 3.58 94.7 µM 2.98E-5 27 1.74E-4
16 SGTC_358 0075-0058 3.57 9.4 µM 3.16E-5 80 1.82E-4
17 SGTC_2678 equilin 3.46 100.0 µM 5.20E-5 36 2.72E-4
18 SGTC_3219 9131112 3.44 49.5 µM 5.70E-5 Golgi 51 2.93E-4
19 SGTC_36 0335-0881 3.43 14.2 µM 5.96E-5 ubiquinone biosynthesis & proteasome 147 3.03E-4
20 SGTC_637 1181-0519 3.38 7.3 µM 7.58E-5 fatty acid desaturase (OLE1) 135 3.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.225 9.43E-40 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.206 3.53E-33 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.203 2.15E-32 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.197 1.03E-30 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.184 5.63E-27 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.179 1.26E-25 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.178 2.07E-25 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.173 7.54E-24 YCR021C HSP30 hom Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
0.167 2.49E-22 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.162 3.32E-21 YJR091C JSN1 hom Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl
0.155 1.31E-19 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.152 7.25E-19 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.152 7.96E-19 YKL185W ASH1 hom Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
0.152 1.00E-18 YKL130C SHE2 hom RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
0.142 1.60E-16 YIL056W VHR1 hom Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication