YOR378W_p

Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR378W / YOR378W

Click on Significant Values for Screen Details ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.05|P-value:4.03E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.40|P-value:9.29E-5 ID:SGTC_443|Compound:clozapine|FD-Score:3.05|P-value:4.08E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.89|P-value:7.43E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.97|P-value:6.76E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:2.98|P-value:5.48E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.37|P-value:1.10E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.54|P-value:5.11E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:3.90|P-value:9.57E-6 ID:SGTC_919|Compound:tnp00227|FD-Score:3.75|P-value:1.94E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.29|P-value:1.57E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.29|P-value:1.57E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.80|P-value:1.51E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.62|P-value:3.44E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.16|P-value:2.45E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:-2.85|P-value:8.80E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:2.83|P-value:9.75E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.42|P-value:8.88E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:2.97|P-value:5.58E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:-2.82|P-value:9.61E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:-2.96|P-value:5.74E-4 ID:SGTC_1774|Compound:st048371|FD-Score:-3.65|P-value:3.06E-5 ID:SGTC_1957|Compound:st077035|FD-Score:-3.45|P-value:7.66E-5 ID:SGTC_2309|Compound:7664088|FD-Score:2.92|P-value:6.91E-4 ID:SGTC_2396|Compound:5342950|FD-Score:5.15|P-value:8.10E-9 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.42|P-value:8.45E-5 ID:SGTC_2868|Compound:9035608|FD-Score:-3.05|P-value:4.04E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.02|P-value:4.67E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-2.83|P-value:9.50E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.05|P-value:4.03E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.40|P-value:9.29E-5 ID:SGTC_443|Compound:clozapine|FD-Score:3.05|P-value:4.08E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.89|P-value:7.43E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.97|P-value:6.76E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:2.98|P-value:5.48E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.37|P-value:1.10E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.54|P-value:5.11E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:3.90|P-value:9.57E-6 ID:SGTC_919|Compound:tnp00227|FD-Score:3.75|P-value:1.94E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.29|P-value:1.57E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.29|P-value:1.57E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.80|P-value:1.51E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.62|P-value:3.44E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.16|P-value:2.45E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:-2.85|P-value:8.80E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:2.83|P-value:9.75E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.42|P-value:8.88E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:2.97|P-value:5.58E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:-2.82|P-value:9.61E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:-2.96|P-value:5.74E-4 ID:SGTC_1774|Compound:st048371|FD-Score:-3.65|P-value:3.06E-5 ID:SGTC_1957|Compound:st077035|FD-Score:-3.45|P-value:7.66E-5 ID:SGTC_2309|Compound:7664088|FD-Score:2.92|P-value:6.91E-4 ID:SGTC_2396|Compound:5342950|FD-Score:5.15|P-value:8.10E-9 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.42|P-value:8.45E-5 ID:SGTC_2868|Compound:9035608|FD-Score:-3.05|P-value:4.04E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.02|P-value:4.67E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-2.83|P-value:9.50E-4

Top fitness defect scores for YOR378W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2396 5342950 5.15 42.8 µM 8.10E-9 RSC complex & mRNA processing 20 1.30E-7
2 SGTC_668 1682-0499 3.97 62.6 µM 6.76E-6 21 3.62E-5
3 SGTC_916 4466-0038 3.90 42.0 nM 9.57E-6 cell wall 71 4.84E-5
4 SGTC_1115 galangin 3.80 695.7 nM 1.51E-5 RPP1 & pyrimidine depletion 18 7.12E-5
5 SGTC_919 tnp00227 3.75 403.6 nM 1.94E-5 RNA pol III & RNase P/MRP 42 8.77E-5
6 SGTC_822 1487-0950 3.54 154.0 µM 5.11E-5 25 1.97E-4
7 SGTC_1139 k015-0024 3.42 46.9 µM 8.88E-5 PDR1 22 3.14E-4
8 SGTC_816 0325-0417 3.37 81.3 µM 1.10E-4 27 3.76E-4
9 SGTC_1031 k035-0009 3.29 16.0 µM 1.57E-4 60 5.07E-4
10 SGTC_1035 k081-0041 3.29 55.2 µM 1.57E-4 Golgi 43 5.08E-4
11 SGTC_443 clozapine 3.05 122.0 µM 4.08E-4 NEO1-PIK1 23 0.00113
12 SGTC_2970 9090938 3.02 41.9 µM 4.67E-4 RNA processing & uracil transport 105 0.00127
13 SGTC_785 1270-0111 2.98 65.3 µM 5.48E-4 73 0.00145
14 SGTC_1151 3909-8316 2.97 15.3 µM 5.58E-4 61 0.00147
15 SGTC_2309 7664088 2.92 163.9 µM 6.91E-4 113 0.00176
16 SGTC_1138 3761-0006 2.83 1.0 µM 9.75E-4 34 0.00236
17 SGTC_3024 9090631 2.78 49.5 µM 0.00118 42 0.00276
18 SGTC_1379 2144-0755 2.74 36.5 µM 0.00134 92 0.00308
19 SGTC_1077 5-fluorocytosine 2.71 377.0 nM 0.00151 exosome 69 0.00340
20 SGTC_1799 st045822 2.68 46.1 µM 0.00168 73 0.00373

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 6.22E-18 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.137 1.81E-15 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.128 8.59E-14 YBL053W_d YBL053W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.116 1.53E-11 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.115 2.55E-11 YKL015W PUT3 hom Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain
0.113 6.04E-11 YDR053W_d YDR053W_d het Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex
0.106 8.72E-10 YOR172W YRM1 hom Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes
0.104 1.38E-9 YMR039C SUB1 hom Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress
0.104 1.78E-9 YHL046C PAU13 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock
0.101 4.66E-9 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.100 8.04E-9 YGR038W ORM1 hom Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control
0.098 1.32E-8 YBR135W CKS1 het Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters
0.097 1.83E-8 YBR196C-B_p YBR196C-B_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.096 2.41E-8 YLR018C POM34 hom Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication
0.095 3.35E-8 YGL098W USE1 het Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p