YOR380W / RDR1

Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR380W / RDR1

Click on Significant Values for Screen Details ID:SGTC_82|Compound:0054-0107|FD-Score:-3.60|P-value:2.12E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:4.16|P-value:1.67E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:4.96|P-value:3.98E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:3.24|P-value:6.00E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.38|P-value:3.66E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.37|P-value:4.75E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.49|P-value:2.46E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:-4.32|P-value:1.09E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:3.17|P-value:7.75E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-4.30|P-value:1.24E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.78|P-value:8.06E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.20|P-value:6.99E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:4.73|P-value:1.23E-6 ID:SGTC_1466|Compound:k213-0079|FD-Score:-4.52|P-value:4.48E-6 ID:SGTC_1477|Compound:0139-0234|FD-Score:-3.92|P-value:6.07E-5 ID:SGTC_1563|Compound:conessine|FD-Score:-3.62|P-value:1.92E-4 ID:SGTC_1644|Compound:st010134|FD-Score:-3.48|P-value:3.26E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-4.67|P-value:2.26E-6 ID:SGTC_1833|Compound:st055984|FD-Score:3.70|P-value:1.10E-4 ID:SGTC_2004|Compound:4023728|FD-Score:7.12|P-value:7.77E-13 ID:SGTC_2008|Compound:4012253|FD-Score:4.67|P-value:1.71E-6 ID:SGTC_2024|Compound:5144227|FD-Score:3.51|P-value:2.35E-4 ID:SGTC_2063|Compound:5246145|FD-Score:5.10|P-value:1.91E-7 ID:SGTC_2066|Compound:5222451|FD-Score:3.29|P-value:5.13E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.28|P-value:6.66E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-3.40|P-value:4.33E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.87|P-value:6.36E-7 ID:SGTC_2693|Compound:st077581|FD-Score:-4.20|P-value:1.86E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.21|P-value:6.82E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.25|P-value:5.95E-4 ID:SGTC_2999|Compound:9069765|FD-Score:4.33|P-value:7.95E-6 ID:SGTC_3129|Compound:9127257|FD-Score:3.11|P-value:9.59E-4 ID:SGTC_3257|Compound:9139206|FD-Score:-3.22|P-value:8.20E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:-3.60|P-value:2.12E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:4.16|P-value:1.67E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:4.96|P-value:3.98E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:3.24|P-value:6.00E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.38|P-value:3.66E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.37|P-value:4.75E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.49|P-value:2.46E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:-4.32|P-value:1.09E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:3.17|P-value:7.75E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-4.30|P-value:1.24E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.78|P-value:8.06E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.20|P-value:6.99E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:4.73|P-value:1.23E-6 ID:SGTC_1466|Compound:k213-0079|FD-Score:-4.52|P-value:4.48E-6 ID:SGTC_1477|Compound:0139-0234|FD-Score:-3.92|P-value:6.07E-5 ID:SGTC_1563|Compound:conessine|FD-Score:-3.62|P-value:1.92E-4 ID:SGTC_1644|Compound:st010134|FD-Score:-3.48|P-value:3.26E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-4.67|P-value:2.26E-6 ID:SGTC_1833|Compound:st055984|FD-Score:3.70|P-value:1.10E-4 ID:SGTC_2004|Compound:4023728|FD-Score:7.12|P-value:7.77E-13 ID:SGTC_2008|Compound:4012253|FD-Score:4.67|P-value:1.71E-6 ID:SGTC_2024|Compound:5144227|FD-Score:3.51|P-value:2.35E-4 ID:SGTC_2063|Compound:5246145|FD-Score:5.10|P-value:1.91E-7 ID:SGTC_2066|Compound:5222451|FD-Score:3.29|P-value:5.13E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.28|P-value:6.66E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-3.40|P-value:4.33E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.87|P-value:6.36E-7 ID:SGTC_2693|Compound:st077581|FD-Score:-4.20|P-value:1.86E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.21|P-value:6.82E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.25|P-value:5.95E-4 ID:SGTC_2999|Compound:9069765|FD-Score:4.33|P-value:7.95E-6 ID:SGTC_3129|Compound:9127257|FD-Score:3.11|P-value:9.59E-4 ID:SGTC_3257|Compound:9139206|FD-Score:-3.22|P-value:8.20E-4

Top fitness defect scores for YOR380W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2004 4023728 7.12 41.9 µM 7.77E-13 3 5.50E-13
2 SGTC_2063 5246145 5.10 200.0 µM 1.91E-7 11 1.67E-7
3 SGTC_131 0141-0277 4.96 33.9 µM 3.98E-7 15 3.52E-7
4 SGTC_2504 purpurogallin 4.87 52.3 µM 6.36E-7 RPP1 & pyrimidine depletion 7 5.67E-7
5 SGTC_1464 k208-0027 4.73 110.0 µM 1.23E-6 14 1.11E-6
6 SGTC_2008 4012253 4.67 172.0 µM 1.71E-6 9 1.54E-6
7 SGTC_2999 9069765 4.33 71.4 µM 7.95E-6 amide catabolism 16 7.36E-6
8 SGTC_94 0334-0113 4.16 514.8 µM 1.67E-5 18 1.56E-5
9 SGTC_1010 4112-3296 3.78 15.2 µM 8.06E-5 20 7.71E-5
10 SGTC_1833 st055984 3.70 71.0 µM 1.10E-4 21 1.06E-4
11 SGTC_2024 5144227 3.51 134.0 µM 2.35E-4 52 2.28E-4
12 SGTC_418 lividomycin a 3.49 100.0 µM 2.46E-4 22 2.39E-4
13 SGTC_344 k064-0035 3.38 6.4 µM 3.66E-4 60S ribosome export 42 3.57E-4
14 SGTC_2066 5222451 3.29 176.0 µM 5.13E-4 heme biosynthesis & mitochondrial translocase 61 5.03E-4
15 SGTC_2991 9074669 3.25 71.4 µM 5.95E-4 azole & statin 102 5.85E-4
16 SGTC_145 3737-0113 3.24 38.4 µM 6.00E-4 DNA intercalators 115 5.90E-4
17 SGTC_2807 7945238 3.21 52.0 µM 6.82E-4 66 6.72E-4
18 SGTC_1461 k072-0203 3.20 53.8 µM 6.99E-4 38 6.89E-4
19 SGTC_516 3992-2719 3.17 87.3 µM 7.75E-4 43 7.64E-4
20 SGTC_3129 9127257 3.11 49.5 µM 9.59E-4 60 9.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 9.96E-18 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.123 7.20E-13 YMR199W CLN1 hom G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
0.109 2.73E-10 YML047W-A_d YML047W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.108 3.18E-10 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.108 4.14E-10 YML058W SML1 hom Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
0.106 7.62E-10 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.105 9.61E-10 YKR079C TRZ1 het tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2
0.103 2.07E-9 YLR307W CDA1 hom Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
0.100 6.91E-9 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.098 1.16E-8 YDR185C UPS3 hom Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations
0.097 1.94E-8 YJR004C SAG1 hom Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
0.095 3.26E-8 YGR098C ESP1 het Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress
0.093 6.41E-8 YPL250C ICY2 hom Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
0.089 2.57E-7 YOR121C_d YOR121C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W
0.089 2.81E-7 YER104W RTT105 het Protein with a role in regulation of Ty1 transposition