YOR382W / FIT2

Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR382W / FIT2

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:3.28|P-value:8.44E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.88|P-value:5.93E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:-2.81|P-value:7.82E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-6.29|P-value:5.44E-13 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.81|P-value:8.58E-6 ID:SGTC_389|Compound:tpck|FD-Score:-2.99|P-value:3.76E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:2.77|P-value:7.16E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:2.74|P-value:8.07E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:2.80|P-value:6.55E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:2.88|P-value:4.72E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.33|P-value:6.77E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:3.57|P-value:2.11E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:2.79|P-value:6.80E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:2.73|P-value:8.67E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:4.27|P-value:5.06E-7 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.95|P-value:2.96E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:3.16|P-value:1.40E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:-3.37|P-value:7.39E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.76|P-value:7.48E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:-3.69|P-value:1.55E-5 ID:SGTC_1335|Compound:1486-0900|FD-Score:-2.82|P-value:7.62E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.87|P-value:4.85E-4 ID:SGTC_1654|Compound:st012436|FD-Score:3.00|P-value:2.84E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-2.98|P-value:4.02E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.03|P-value:2.51E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-3.13|P-value:2.14E-4 ID:SGTC_1997|Compound:st073024|FD-Score:2.88|P-value:4.67E-4 ID:SGTC_2167|Compound:5876490|FD-Score:2.82|P-value:5.89E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-4.29|P-value:6.43E-7 ID:SGTC_2295|Compound:7971645|FD-Score:3.43|P-value:4.13E-5 ID:SGTC_2299|Compound:7976368|FD-Score:3.21|P-value:1.17E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-5.73|P-value:4.61E-11 ID:SGTC_2304|Compound:7443016|FD-Score:-3.03|P-value:3.24E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.30|P-value:7.61E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-3.20|P-value:1.53E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.12|P-value:1.71E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:2.71|P-value:9.11E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:2.70|P-value:9.40E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.53|P-value:2.54E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:8.92|P-value:1.31E-24 ID:SGTC_2666|Compound:tannic acid|FD-Score:12.50|P-value:4.28E-46 ID:SGTC_2805|Compound:7950783|FD-Score:-3.03|P-value:3.28E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.21|P-value:1.13E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.14|P-value:1.57E-4 ID:SGTC_3086|Compound:9117350|FD-Score:2.71|P-value:9.02E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.28|P-value:8.44E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.88|P-value:5.93E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:-2.81|P-value:7.82E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-6.29|P-value:5.44E-13 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.81|P-value:8.58E-6 ID:SGTC_389|Compound:tpck|FD-Score:-2.99|P-value:3.76E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:2.77|P-value:7.16E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:2.74|P-value:8.07E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:2.80|P-value:6.55E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:2.88|P-value:4.72E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.33|P-value:6.77E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:3.57|P-value:2.11E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:2.79|P-value:6.80E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:2.73|P-value:8.67E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:4.27|P-value:5.06E-7 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.95|P-value:2.96E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:3.16|P-value:1.40E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:-3.37|P-value:7.39E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.76|P-value:7.48E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:-3.69|P-value:1.55E-5 ID:SGTC_1335|Compound:1486-0900|FD-Score:-2.82|P-value:7.62E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.87|P-value:4.85E-4 ID:SGTC_1654|Compound:st012436|FD-Score:3.00|P-value:2.84E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-2.98|P-value:4.02E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.03|P-value:2.51E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-3.13|P-value:2.14E-4 ID:SGTC_1997|Compound:st073024|FD-Score:2.88|P-value:4.67E-4 ID:SGTC_2167|Compound:5876490|FD-Score:2.82|P-value:5.89E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-4.29|P-value:6.43E-7 ID:SGTC_2295|Compound:7971645|FD-Score:3.43|P-value:4.13E-5 ID:SGTC_2299|Compound:7976368|FD-Score:3.21|P-value:1.17E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-5.73|P-value:4.61E-11 ID:SGTC_2304|Compound:7443016|FD-Score:-3.03|P-value:3.24E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.30|P-value:7.61E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-3.20|P-value:1.53E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.12|P-value:1.71E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:2.71|P-value:9.11E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:2.70|P-value:9.40E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.53|P-value:2.54E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:8.92|P-value:1.31E-24 ID:SGTC_2666|Compound:tannic acid|FD-Score:12.50|P-value:4.28E-46 ID:SGTC_2805|Compound:7950783|FD-Score:-3.03|P-value:3.28E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.21|P-value:1.13E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.14|P-value:1.57E-4 ID:SGTC_3086|Compound:9117350|FD-Score:2.71|P-value:9.02E-4

Top fitness defect scores for YOR382W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2666 tannic acid 12.50 100.0 µM 4.28E-46 iron homeostasis 1 6.05E-36
2 SGTC_2615 purpurogallin-4-carboxylic acid 8.92 100.0 µM 1.31E-24 redox potentiating 12 2.41E-19
3 SGTC_1059 3448-6867 4.27 171.0 µM 5.06E-7 7 9.77E-6
4 SGTC_1112 tnp00069 3.95 1.2 µM 2.96E-6 20 3.85E-5
5 SGTC_790 1575-0012 3.57 79.1 µM 2.11E-5 TSC3-RPN4 41 1.77E-4
6 SGTC_2583 asiatic acid 3.53 100.0 µM 2.54E-5 49 2.05E-4
7 SGTC_2295 7971645 3.43 200.0 µM 4.13E-5 41 2.99E-4
8 SGTC_775 4577-0580 3.33 57.3 µM 6.77E-5 18 4.40E-4
9 SGTC_2407 paclitaxel 3.30 400.0 µM 7.61E-5 60 4.82E-4
10 SGTC_56 0957-0365 3.28 83.2 µM 8.44E-5 Golgi 74 5.22E-4
11 SGTC_2809 7964133 3.21 13.0 µM 1.13E-4 60S ribosome export 80 6.57E-4
12 SGTC_2299 7976368 3.21 114.9 µM 1.17E-4 54 6.74E-4
13 SGTC_1124 fisetin 3.16 1.2 µM 1.40E-4 68 7.76E-4
14 SGTC_2999 9069765 3.14 71.4 µM 1.57E-4 amide catabolism 65 8.46E-4
15 SGTC_2504 purpurogallin 3.12 52.3 µM 1.71E-4 RPP1 & pyrimidine depletion 48 9.03E-4
16 SGTC_1921 5740136 3.03 50.0 µM 2.51E-4 TRP & mitochondrial translation 114 0.00122
17 SGTC_1654 st012436 3.00 41.8 µM 2.84E-4 43 0.00134
18 SGTC_1997 st073024 2.88 93.8 µM 4.67E-4 40 0.00198
19 SGTC_763 3453-1109 2.88 128.0 µM 4.72E-4 63 0.00200
20 SGTC_1584 6-fluoro-dl-tryptophan 2.87 90.0 µM 4.85E-4 mitochondrial processes 72 0.00204

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.226 2.88E-40 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.173 5.89E-24 YLR220W CCC1 hom Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress
0.166 3.99E-22 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.154 2.81E-19 YOR384W FRE5 hom Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.132 1.69E-14 YBL059W_p YBL059W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication
0.131 2.87E-14 YKL099C UTP11 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.127 1.47E-13 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.123 8.39E-13 YFL008W SMC1 het Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
0.120 2.94E-12 YJL109C UTP10 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance
0.120 3.15E-12 YBR157C ICS2 hom Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
0.119 4.46E-12 YNR035C ARC35 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin
0.118 6.39E-12 YPL222W_p FMP40_p hom Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.115 2.29E-11 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.113 4.37E-11 YHR104W GRE3 hom Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress
0.111 1.12E-10 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly