YPL009C / TAE2

Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL009C / TAE2

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:3.30|P-value:3.39E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.08|P-value:6.90E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.18|P-value:4.79E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.04|P-value:8.78E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.19|P-value:5.21E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.89|P-value:3.14E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:3.52|P-value:1.47E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.75|P-value:5.78E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.34|P-value:1.92E-8 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.02|P-value:8.46E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.67|P-value:7.70E-7 ID:SGTC_679|Compound:0422-0091|FD-Score:4.66|P-value:7.99E-7 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.00|P-value:8.94E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:4.86|P-value:2.73E-7 ID:SGTC_822|Compound:1487-0950|FD-Score:3.43|P-value:2.12E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.04|P-value:1.60E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:4.59|P-value:1.13E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:5.19|P-value:4.41E-8 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.04|P-value:8.78E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.94|P-value:2.49E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:-4.19|P-value:6.87E-6 ID:SGTC_1419|Compound:3993-2473|FD-Score:5.75|P-value:1.53E-9 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.54|P-value:1.36E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-3.51|P-value:1.31E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.33|P-value:3.06E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-3.23|P-value:3.92E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-3.83|P-value:3.49E-5 ID:SGTC_2067|Compound:5224629|FD-Score:3.24|P-value:4.31E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.13|P-value:5.69E-4 ID:SGTC_2267|Compound:7931562|FD-Score:4.23|P-value:6.67E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.23|P-value:3.87E-4 ID:SGTC_2424|Compound:5537928|FD-Score:5.04|P-value:1.05E-7 ID:SGTC_2429|Compound:5902844|FD-Score:4.29|P-value:5.05E-6 ID:SGTC_2432|Compound:5630864|FD-Score:-4.01|P-value:1.54E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.07|P-value:8.12E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.02|P-value:9.55E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.20|P-value:7.79E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.34|P-value:2.92E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.37|P-value:2.81E-6 ID:SGTC_2873|Compound:9040596|FD-Score:4.71|P-value:6.26E-7 ID:SGTC_2995|Compound:9067767|FD-Score:3.26|P-value:4.05E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.64|P-value:9.14E-5 ID:SGTC_3044|Compound:9093193|FD-Score:-3.30|P-value:3.00E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.84|P-value:3.86E-5 ID:SGTC_3303|Compound:9125618|FD-Score:-4.44|P-value:2.04E-6 ID:SGTC_3308|Compound:9128332|FD-Score:-4.02|P-value:1.48E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:3.30|P-value:3.39E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.08|P-value:6.90E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.18|P-value:4.79E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.04|P-value:8.78E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.19|P-value:5.21E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.89|P-value:3.14E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:3.52|P-value:1.47E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.75|P-value:5.78E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.34|P-value:1.92E-8 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.02|P-value:8.46E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.67|P-value:7.70E-7 ID:SGTC_679|Compound:0422-0091|FD-Score:4.66|P-value:7.99E-7 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.00|P-value:8.94E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:4.86|P-value:2.73E-7 ID:SGTC_822|Compound:1487-0950|FD-Score:3.43|P-value:2.12E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.04|P-value:1.60E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:4.59|P-value:1.13E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:5.19|P-value:4.41E-8 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.04|P-value:8.78E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.94|P-value:2.49E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:-4.19|P-value:6.87E-6 ID:SGTC_1419|Compound:3993-2473|FD-Score:5.75|P-value:1.53E-9 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.54|P-value:1.36E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-3.51|P-value:1.31E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.33|P-value:3.06E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-3.23|P-value:3.92E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-3.83|P-value:3.49E-5 ID:SGTC_2067|Compound:5224629|FD-Score:3.24|P-value:4.31E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.13|P-value:5.69E-4 ID:SGTC_2267|Compound:7931562|FD-Score:4.23|P-value:6.67E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.23|P-value:3.87E-4 ID:SGTC_2424|Compound:5537928|FD-Score:5.04|P-value:1.05E-7 ID:SGTC_2429|Compound:5902844|FD-Score:4.29|P-value:5.05E-6 ID:SGTC_2432|Compound:5630864|FD-Score:-4.01|P-value:1.54E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.07|P-value:8.12E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.02|P-value:9.55E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.20|P-value:7.79E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.34|P-value:2.92E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.37|P-value:2.81E-6 ID:SGTC_2873|Compound:9040596|FD-Score:4.71|P-value:6.26E-7 ID:SGTC_2995|Compound:9067767|FD-Score:3.26|P-value:4.05E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.64|P-value:9.14E-5 ID:SGTC_3044|Compound:9093193|FD-Score:-3.30|P-value:3.00E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.84|P-value:3.86E-5 ID:SGTC_3303|Compound:9125618|FD-Score:-4.44|P-value:2.04E-6 ID:SGTC_3308|Compound:9128332|FD-Score:-4.02|P-value:1.48E-5

Top fitness defect scores for YPL009C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1419 3993-2473 5.75 62.6 µM 1.53E-9 2 4.41E-9
2 SGTC_445 e6 berbamine 5.34 66.0 µM 1.92E-8 NEO1-PIK1 48 4.78E-8
3 SGTC_936 3005-4620 5.19 401.0 µM 4.41E-8 6 1.04E-7
4 SGTC_2424 5537928 5.04 59.2 µM 1.05E-7 15 2.35E-7
5 SGTC_746 1095-0025 4.86 46.6 µM 2.73E-7 RSC & ERG11 8 5.79E-7
6 SGTC_2873 9040596 4.71 71.4 µM 6.26E-7 28 1.26E-6
7 SGTC_534 k292-0788 4.67 63.4 µM 7.70E-7 mitochondrial processes 14 1.54E-6
8 SGTC_679 0422-0091 4.66 41.4 µM 7.99E-7 Golgi 15 1.59E-6
9 SGTC_925 2064-1272 4.59 59.6 µM 1.13E-6 13 2.21E-6
10 SGTC_2429 5902844 4.29 64.4 µM 5.05E-6 13 9.03E-6
11 SGTC_2267 7931562 4.23 200.0 µM 6.67E-6 15 1.17E-5
12 SGTC_2561 acetosyringone 4.20 100.0 µM 7.79E-6 15 1.36E-5
13 SGTC_916 4466-0038 4.04 42.0 nM 1.60E-5 cell wall 67 2.68E-5
14 SGTC_1386 3228-0095 3.94 33.8 µM 2.49E-5 18 4.06E-5
15 SGTC_160 3453-0671 3.89 289.7 µM 3.14E-5 41 5.05E-5
16 SGTC_3205 9113483 3.84 49.5 µM 3.86E-5 33 6.13E-5
17 SGTC_295 k015-0027 3.75 31.0 µM 5.78E-5 PDR1 11 8.98E-5
18 SGTC_3003 9075612 3.64 71.4 µM 9.14E-5 25 1.38E-4
19 SGTC_1423 4048-0112 3.54 5.6 µM 1.36E-4 35 2.01E-4
20 SGTC_194 1486-1323 3.52 56.9 µM 1.47E-4 31 2.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 1.02E-9 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.104 1.69E-9 YHR200W RPN10 hom Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
0.098 1.24E-8 YER118C SHO1 hom Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
0.092 1.07E-7 YOR080W DIA2 hom Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.087 4.28E-7 YOL060C MAM3 hom Protein required for normal mitochondrial morphology, has similarity to hemolysins
0.087 4.78E-7 YPL163C SVS1 hom Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication
0.081 2.71E-6 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.079 4.21E-6 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.078 5.59E-6 YBR104W YMC2 hom Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication
0.078 5.77E-6 YKL045W PRI2 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.078 6.22E-6 YCL033C MXR2 hom Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan
0.078 6.85E-6 YAL040C CLN3 hom G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis
0.077 7.65E-6 YGR268C HUA1 hom Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
0.075 1.47E-5 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.073 2.04E-5 YOR378W_p YOR378W_p hom Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene